<i><scp>IRAK</scp>1</i> variant is protective for orthodontic‐induced external apical root resorption

Pereira, Sónia Alves; Nogueira, Lafayette; Canova, Filomena; López, Miguel; Silva, Henriqueta Coimbra

doi:10.1111/odi.12514

Cited by 24 publications

(40 citation statements)

References 42 publications

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“…The initial tooth displacement due to orthodontic force determines, especially in the early stages of OTM [2,4], the increase of stress in the periodontal ligament which determines the osteogenic response of the alveolar bone responsible for the subsequent tissue remodeling [7,8,9]. This could result in a significant reduction in the speed of OTM and in related phenomena such as in gingivitis, dental ankyloses, and root resorption [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial

et al. 2019

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The present study evaluated the effects of low-level laser therapy (LLLT) by means of a diode laser in accelerating orthodontic tooth movement (OTM). After extraction of the first upper premolars for orthodontic purpose, 82 maxillary canines which needed distalization were analyzed in 41 enrolled patients (21 males, 20 females, mean age 13.4 ± 2.1 years). On all experimental sites, an orthodontic force of 50/N was applied by a nickel-titanium (NiTi) closed coil spring (G&H, Franklin, IN, USA) in order to obtain the space closure. Using a split mouth randomized design, the test side was treated using a diode laser (Wiser Laser Doctor Smile, Brendola, Italy) operating at 810 nm wavelength in continuous wave mode at both the buccal and palatal side on three points/side (distal, medial and mesial) (1 W output power, continuous wave of 66.7 J/cm2, energy density of 8 J) at baseline and at 3, 7, and 14 days and every 15 days until the space closed. On the control side, the opposite selected canine was treated only using orthodontic traction. The primary outcome chosen was the overall time needed to complete the levelling and closing space, measured on a study cast. The secondary outcome chosen was the evaluation of pain levels related to tooth traction, using a Visual Analogue Scale (VAS), recorded at 3, 7, and 14 days after treatments. The mean space closures of the maxillary canines were comparable between groups [Test, 4.56 mm (95% CI 3.9–4.8); Control, 4.49 mm (95% CI 3.8–4.7), p = 0.456]. The laser group yielded less mean time [84.35 ± 12.34 days (95% CI 79.3–86)] to accomplish space closure compared to the control group [97.49 ± 11.44 days (91.7–102.3)] (p < 0.001). The test side showed a significant reduction in the average range of dental pain at 3 [Test, 5.41 (95% CI 5.1–5.6); Control, 7.23 (95% CI 6.9–7.6), p < 0.001], 7 [Test, 4.12 (95% CI 3.8–4.7); Control, 5.79 (95% CI 5.4–5.8), p < 0.001], and at 14 days [Test, 2.31 (95% CI 1.8–2.3); Control, 3.84 (95% CI 3.3–4.2), p < 0.001] after treatment (p < 0.001). This study demonstrates that the use of LLLT therapy was effective in accelerating tooth movement and reducing pain levels related to OTM.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial

et al. 2019

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“…Cytokines, specifically IL, disturb bone remodeling and play a vigorous role in pathological and physiological bone regulation. Osteoclasts and osteoblasts like cells are involved in bone resorption and formation [21,22]. IL-1 is one of the most important monocyte-macrophage-derived cytokines that acts as a potent stimulator of bone resorption in organ culture [22].…”

Section: Discussionmentioning

confidence: 99%

External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies

Nowrin

Jaafar

Rahman

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR. Material and Methods: The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020. Results: A total of 13 and 9 publications were selected for the systematic review and metaanalysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR. Conclusion: More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.

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“…Inflammatory bone loss with high expression of IL1β is a common finding in clinical settings, such as osteoarthritis 31 and rheumatoid arthritis, 32 also including alveolar bone loss caused by periodontitis 33 and cementum loss due to orthodontic root resorption. 34 As two of the most important inflammatory factors, TNF-α and IL1β had some different reactions in miRNA-mediated in inflammatory diseases. TNF-α had a similar inhibitory effect on cementoblast differentiation, but it was mainly regulated by another miRNA, miR-155-3p, targeting the kctd1 gene through the canonical Wnt signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

IL1β inhibits differentiation of cementoblasts via microRNA‐325‐3p

Wang

Shao

et al. 2019

J of Cellular Biochemistry

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Cementum regeneration is considered the gold standard for the treatment of periodontitis. As one of the most important primary proinflammatory cytokines, interleukin 1β (IL1β) plays an essential role during the early stage of periodontitis and its amounts simultaneously increase dramatically during this stage. Though promising, the differentiation of cementoblasts upon IL1β-induced inflammation of the microenvironment and the relative interaction mechanism are still unknown.Here, we found that IL1β inhibited cementoblast differentiation and microRNA-325-3p (miR-325-3p) was increased during IL1β-stimulated cementoblasts. Bioinformatics analysis and luciferase reporter assay demonstrated miR-325-3p targeted runt-related transcription factor 2 directly. Transfection of miR-325-3p suppressed cementoblast differentiation in vitro and the formation of cementum-like tissues in vivo. The inhibitor of miR-325-3p could mitigate the above effects induced by IL1β. Accordingly, our finding suggests a critical role of miR-325-3p in linking inflammation to impaired cementum regeneration and provides a potential possibility for applying miR-325-3p inhibitors in the treatment of periodontitisrelated bone loss.

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IRAK1 variant is protective for orthodontic‐induced external apical root resorption

Abstract: IRAK1 polymorphism is proposed as a protective variant for EARR.

Cited by 24 publications

References 42 publications

Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial

Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial

External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies

IL1β inhibits differentiation of cementoblasts via microRNA‐325‐3p

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