A Clinical Review of Pulmonary Microlithiasis

Meyer, Heinz; Gilbert, Earl S.; Kent, Geoffrey

doi:10.1001/jama.1956.62970120001010

Cited by 20 publications

(3 citation statements)

References 9 publications

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“…Many of the necropsy reports on previous cases do not mention macroscopic or histological examination of the large airways (Caffrey and Altman, 1965;Meyer, Gilbert, and Kent, 1956;Abdel-Hakim, El-Mallah, Hashem, and Abdel-Halim, 1959;Waters, 1960) and in those cases with reports of bronchial examination, the bronchi were normal (Harbitz, 1918;Sharp and Danino, 1953;Sosman et al, 1957;Gomez et al, 1959;Chinachoti and Tangchai, 1957;Hotchi et al, 1970). However, Portnoy et al (1964), in their patient with the milkalkali syndrome, hypercalcaemia, and renal lithiasis as well as pulmonary alveolar microlithiasis, found evidence of slight calcification of the bronchial mucous membrane.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary alveolar microlithiasis

Sears

Chang

Taylor

1971

Thorax

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Section: Discussionmentioning

confidence: 99%

Pulmonary alveolar microlithiasis

Sears

Chang

Taylor

1971

Thorax

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“…17,19,25 It affects all ages, and there is no gender predilection. 17,19 Possible etiologies include an inherited metabolic abnormality in the lung, 19 abnormalities in calcium and phosphorus metabolism, 2 abnormalities in the immune system, 18 environmental factors, 19,21 and anatomic and physiologic abnormalities of the lung. 19,25 Although nackt mice are maintained in congenic strains, evaluation of archived tissue and more recent animals presented for routine health surveillance (Ͼ20 mice) has failed to demonstrate microlithiasis.…”

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confidence: 99%

A Variant of Pulmonary Alveolar Microlithiasis in nackt Mice

Starost¹,

Benavides²,

Conti³

2002

Vet Pathol

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Four adult mutant nackt mice, which demonstrate alopecia and CD4+ T-cell deficiency, and two outbred SENCAR mice (sentinels) were presented for routine health surveillance. Lesions were not observed at necropsy. Microscopically, all four nackt mice demonstrated multiple concretions that were 30-100 microm in diameter, irregularly rounded to oval, nonbirefringent, and amphophilic to basophilic. Many of the concretions appeared attached to or within the alveolar walls of all lung lobes. Approximately half of the concretions had irregular fracture lines. All concretions were periodic acid-Schiff positive, and Von Kassa staining revealed diffuse calcification. None of the concretions were associated with inflammatory cell infiltrates, and metaplastic ossification was not evident. A diagnosis of pulmonary alveolar microlithiasis, a rare disease in both humans and animals, was made based on the size and location of the concretions and the lack of an inflammatory response. This is the first report of a laboratory mouse demonstrating pulmonary alveolar microlithiasis.

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“…The etiology of the disease is unknown but many theories have been suggested. Possible etiologies include an inherited metabolic abnormality in the lung (Moran et al, 1997), abnormalities in calcium and phosphorus metabolism (Arslan et al, 1996), abnormalities in the immune system (Meyer et al, 1956), environmental factors (Prakash et al, 1983) and anatomic and physiologic abnormalities of the lung (Sosman et al, 1957;Moran et al, 1997). Recent investigations have identified gene SLC34A2 to be responsible (Gocmen et al, 1992;Yin and Shen, 2011).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary ossification and microlithiasis in a bitch with multicentric mammary tumors

Kubba¹

2017

Open Vet J.

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Microliths and ossification were found in the lungs of a 12-year-old bitch suffering from compound mammary gland tumor which has disseminated in the inguinal lymph node glands and the lungs. Pulmonary ossification appeared grossly as irregular stony sharp particles which infiltrated the lung tissue and were readily recognizable from under the pleura as grayish sharp protruding particles. Microscopic examination revealed the existence of intra-alveolar single or multilobular particles of ossification which are formed of lamellated osseous substance with osteocytes in lacunae. Microlith particles were also seen and were smaller, usually solitary and less frequent. They comprised strongly basophilic smooth laminated spherical particles which may enclose faintly stained substances. Both structures were not associated with inflammatory response. Larger particles appeared as white miliary spots by radiography. This article documents for a very rare case of pulmonary microlithiasis and ossification in a dog.

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A Clinical Review of Pulmonary Microlithiasis

Cited by 20 publications

References 9 publications

Pulmonary alveolar microlithiasis

Pulmonary alveolar microlithiasis

A Variant of Pulmonary Alveolar Microlithiasis in nackt Mice

Pulmonary ossification and microlithiasis in a bitch with multicentric mammary tumors

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