Pulmonary alveolar microlithiasis

Sears, Malcolm R.; Chang, Alex R.; Taylor, A. J.

doi:10.1136/thx.26.6.704

Cited by 46 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Corpora amylacea are not birefringent, do not calcify, the inflammatory reaction is slight, and the PAS reaction is weakly positive. Pulmonary microlithiasis has been described in the dog and man [3,5]. The lesions are diffuse, and the specimens of lung tissue must be decalcified before microscopic examination.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Granulomas Associated with PAS-Positive Bodies in Brachycephalic Dogs

et al. 1972

View full text Add to dashboard Cite

Abstract. Pulmonary granulomas were incidental findings at necropsy in 18 dogs, mainly of the brachycephalic breeds. These lesions were multifocal along smaller bronchi and the subpleural tissue at the margins of lobes. The granulomatous reaction contained numerous periodic acid-Schiff (PAS)-positive bodies that histochemically had reactions suggestive of a calcium-lipid-mucopolysaccharide complex. Although the cause is not clear, the location and distribution are suggestive of an inhalation or aspiration pneumonia.The shortened muzzle of brachycephalic breeds, particularly when there is concurrent upper respiratory disease, may predispose them to these bodies.Pulmonary granulomas of unknown cause were seen at necropsy as incidental findings in 18 dogs with a mean age of 10 years. All but two dogs were from large metropolitan areas of New York City and Philadelphia. Tissue specimens were submitted to the Armed Forces Institute of Pathology for histologic examination. The gross and histologic features of these lesions are described. Materials and MethodsThe breed, sex, and age of each dog is shown in table I. Parts of the pulmonary lesions were fixed in 10% formalin and embedded in paraffin. Sections were cut at 6 pni and stained with haematoxylin and eosin (HE), periodic acid-Schiff (PAS) with and without diastase, Mowry's modification of the colloidal iron stain for acid mucopolysaccharides (AMP) [4], alizarin red S before and after microincineration, Danielli's stain for tyrosinecontaining proteins, alcian blue, oil red 0, and the Prussian blue reaction for iron. Other stains included Congo red for amyloid, Mayer's mucicarmine, and Gomori's methenaminesilver stain (GMS). X-ray diffraction was performed by the powder method and a DebyeScherrer camera [l].

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary Granulomas Associated with PAS-Positive Bodies in Brachycephalic Dogs

et al. 1972

View full text Add to dashboard Cite

show abstract

“…The youngest reported cases were premature monochorionic twins, who died after 12 h of life [13], two newborns [14], an 8-month-old infant [15] and an 18-month-old infant [16]. The most elderly cases at diagnosis were an 84-year-old female [17], an 82-year-old female [18] and an 80-year-old male [19]. Sex appears to be equally distributed in all age groups, except the one ranging between 11 and 30 years, which shows a prevalence of the male sex (male:female ratio 3:2) (online supplementary fig.…”

Section: World Casesmentioning

confidence: 99%

Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide

et al. 2015

View full text Add to dashboard Cite

Pulmonary alveolar microlithiasis (PAM) is a rare disease characterised by the widespread intra-alveolar accumulation of minute calculi called microliths. It is caused by mutation of the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. The present study explores the epidemiological, familial, genetic, clinical, diagnostic, radiological and therapeutic aspects with the aim of contributing to a better understanding of this uncommon disease.We searched articles on PAM published up to December 2014 and 544 papers were found, accounting for 1022 cases.PAM is present in all continents and in many nations, in particular in Turkey, China, Japan, India, Italy and the USA. Familiality is frequent. The clinical course is not uniform and the causes of this clinical variability seem to be largely nongenetic. The optimal diagnostic procedure is the association of chest high-resolution computed tomography (HRCT) with bronchoalveolar lavage, but a chest radiograph may suffice in families in which a case has already been diagnosed. Moreover, chest radiography and HRCT allow the classification of the evolutionary phase of the disease and its severity. At present lung transplantation is the only effective therapy. However, better knowledge of the gene responsible offers hope for new therapies. @ERSpublications Familial, genetic, clinical, radiological and therapeutic aspects of pulmonary alveolar microlithiasis epidemiology http://ow.ly/St3Mw

show abstract

“…3 Disease is prevalent amongst family units with a high rate of consanguinity among the parents of affected individuals suggesting the hypothesis of the role of genetic factors in causing PAM. 9,10,11 Recently, corutctal et al have identified the gene mutation responsible for the disease as SLC34A2 (the type IIb sodium phosphate co-transporter gene), which is involved in phosphate homeostasis in several organs, including the lung surface, readily apparent on HRCT. 12 Asymptomatic cases, even with extensive radiographic involvement, are often discovered incidentally.…”

Section: Discussionmentioning

confidence: 99%