A clinical review of obstetric and perinatal outcome in thyroid disorders

Abstract

Thyroid disorders are the second most common cause of endocrine dysfunction in women of child bearing age after diabetes mellitus. It is now well established that not only overt, but also subclinical thyroid dysfunction have significant adverse effects on pregnancy and fetal development. The adverse pregnancy outcomes include, miscarriage, pregnancy induced hypertension, and its more severe form pre-eclampsia, as well as placental abruption, anaemia, post partum hemorrhage, and increased fetal morbidity and mortality. Thyroid testing is a must at first booking. Adequate replacement therapy should be done to keep TSH with in trimester specific referrence ranges. Early and effective treatment of thyroid disorders ensures safe pregnancy with minimal maternal and fetal complication.