A Clinical, Randomised, Double-Blind Study on the Use of Nano-Hydroxyapatite and Arginine During at-Home Tooth Bleaching

Silva, Ranna Castro da; Alencar, Cristiane de Melo; Silva, Beatriz Helena Rodrigues; Paula, Brennda Lucy Freitas de; Barros, Antônia Patricia Oliveira; Silveira, Ana Daniela Silva da; Silva, Cecy Martins

doi:10.7860/jcdr/2018/37325.12340

Cited by 5 publications

(6 citation statements)

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“…With about one-third concentration of 40% HP (12%), the BT45/HP + NIR system achieved a comparable bleaching effect as the Boost (40% HP). In addition, the HP concentration of the BT45/HP + NIR system is about half of the commercial tooth bleaching product Zoom (25% HP), which employs ferrous gluconate as a Fenton agent. , In addition, 12% HP is in the HP concentration range (6–15%) of home-using tooth whitening products. , Therefore, this BT45/12% HP + NIR bleaching gel with high efficiency and preferable safety has great potential for clinic transformation. Recently, Wang et al reported a tooth whitening strategy realized by the replacement of abrasives traditionally used in toothpaste with piezo-catalyst BaTiO 3 nanoparticles .…”

Section: Resultsmentioning

confidence: 99%

“…22,51 In addition, 12% HP is in the HP concentration range (6−15%) of home-using tooth whitening products. 52,53 Therefore, this BT45/12% HP + NIR bleaching gel with high efficiency and preferable safety has great potential for clinic transformation. Recently, Wang et al reported a tooth whitening strategy realized by the replacement of abrasives traditionally used in toothpaste with piezo-catalyst BaTiO 3 nanoparticles.…”

Section: Photothermal-enhanced Fenton-like Activity Of Tio 2−x (Bt45)mentioning

confidence: 99%

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Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening

Xie

et al. 2021

ACS Appl. Mater. Interfaces

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The growing demand for charming smiles has led to the popularization of tooth bleaching procedures. Current tooth bleaching products with high-concentration hydrogen peroxide (HP, 30–40%) are effective but detrimental due to the increased risk of enamel destruction, tooth sensitivity, and gingival irritation. Herein, we reported a less-destructive and efficient tooth whitening strategy with a low-concentration HP, which was realized by the remarkably enhanced Fenton-like catalytic activity of oxygen-deficient TiO2 (TiO2–x ). TiO2–x nanoparticles were synthesized with a modified solid-state chemical reduction approach with NaBH4. The Fenton-like activity of TiO2–x was optimized by manipulating oxygen vacancy (OV) concentration and further promoted by the near-infrared (NIR)-induced photothermal effect of TiO2–x . The TiO2–x sample named BT45 was chosen due to the highest methylene blue (MB) adsorption ability and Fenton-like activity among acquired samples. The photothermal property of BT45 under 808 nm NIR irradiation was verified and its enhancement on Fenton-like activity was also studied. The BT45/HP + NIR group performed significantly better in tooth whitening than the HP + NIR group on various discolored teeth (stained by Orange II, tea, or rhodamine B). Excitingly, the same tooth whitening performance as the Opalescence Boost, a tooth bleaching product containing 40% HP, was obtained by a self-produced bleaching gel based on this novel system containing 12% HP. Besides, negligible enamel destruction, safe temperature range, and good cytocompatibility of TiO2–x nanoparticles also demonstrated the safety of this tooth bleaching strategy. This work indicated that the photothermal-enhanced Fenton-like performance of the TiO2–x -based system is highly promising in tooth bleaching application and can also be extended to other biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Photothermal-enhanced Fenton-like Activity Of Tio 2−x (Bt45)mentioning

confidence: 99%

Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening

Xie

et al. 2021

ACS Appl. Mater. Interfaces

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“…A recent retrospective study, which collected data from eleven randomized controlled trials, indicated that the risk of TS reported by patients undergoing in-office bleaching was approximately 62.9% [11]. To reduce the TS induced by the action of the bleaching agent, clinical studies have tested the use of topical desensitizing agents [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

et al. 2021

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Objective This split-mouth randomized controlled clinical trial assessed the effect of 10% strontium chloride in combination with photobiomodulation (PBM) for the control of tooth sensitivity (TS) post-bleaching. Methods The upper/lower, right and left quadrants of fifty volunteers were randomized and allocated to four groups (n = 25): PLACEBO—placebo gel + simulation of PBM; Placebo + PBM; STRONTIUM—10% strontium chloride + simulation of PBM; and PBM + STRONTIUM—10% strontium chloride + PBM. All groups received tooth bleaching treatment with 35% hydrogen peroxide. For the PBM treatment, the laser tip was positioned in the apical and cervical regions of the teeth bleached in the respective hemi-arch. The laser system was operated in continuous mode, using 1.7 J of energy. A dose of 60 J/cm2 was applied to each point for 16 seconds under 808 nm near-infrared light (100mW of power), with a point area of 0.028 cm2. TS was assessed during a 21-day follow-up, using the modified visual analogue scale. Results In the intragroup assessment, the Friedman test indicated that PBM + STRONTIUM promoted the greatest reduction in TS after the second week of treatment (p ≤ 0.05). The Wilcoxon-Mann-Whitney test indicated that the groups Placebo + PBM, STRONTIUM, and STRONTIUM + PBM did not differ statistically (p ≥ 0.05) in the first and third weeks of treatment The group PLACEBO exhibited the greatest TS in the first three days after each bleaching session. Conclusion The combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, the combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, it did not differ from the individual use of Placebo + PBM or STRONTIUM groups assessed after 21 days of follow-up.

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“…Da Silva et al . ( 20 ) concluded that the application of the different desensitizing agents can successfully overcome the ordeal of post-bleaching HS. As these obliterating agents were found to enhance the enamel mineral content, impeding H2O2 infiltration to the nerve endings and thereby HS is much reduced or even eliminated completely.…”

Section: Discussionmentioning

confidence: 99%

Effect of Arginine and nano-hydroxyapatite application on the hypersensitivity and color change of bleached enamel: A randomized controlled clinical trial

Moharam¹,

Khadr²,

Abdou³

et al. 2022

J Clin Exp Dent

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A Clinical, Randomised, Double-Blind Study on the Use of Nano-Hydroxyapatite and Arginine During at-Home Tooth Bleaching

Cited by 5 publications

References 0 publications

Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening

Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

Effect of Arginine and nano-hydroxyapatite application on the hypersensitivity and color change of bleached enamel: A randomized controlled clinical trial

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