A Clinical Profile and Factors Associated with Severity of the  Disease Among Polish Patients Hospitalized Due to COVID-19—An Observational Study

Stachura, Tomasz; Celejewska‐Wójcik, Natalia; Polok, Kamil; Górka, Karolina; Lichołai, Sabina; Wójcik, Krzysztof; Krawczyk, Jacek B.; Kozłowska, Anna; Przybyszowski, Marek; Włoch, Tomasz; Górka, Jacek; Sładek, Krzysztof

doi:10.5603/arm.a2021.0035

Cited by 9 publications

(10 citation statements)

References 39 publications

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“…Data included in this study were collected during the first two waves of the COVID-19 pandemic in Poland. During the first wave of the COVID-19 pandemic (the first half of 2020), numerous research centers and COVID-19-dedicated hospitals had published their own experiences on the clinical characteristics of COVID-19 patients [17][18][19]. Often these publications are based on data on the limited number of COVID-19 cases, so the prevalence of ARDS among COVID-19 patients may be overestimated [12,14].…”

Section: Discussionmentioning

confidence: 99%

“…As of 15 December 2021, a total of 3,881,348 laboratory-confirmed COVID-19 cases and 89,714 COVID-related deaths were reported [10]. Data on the clinical characteristic of COVID-19 patients in Poland are mostly limited to single-center studies [11,17,18]. A study carried out between 16 March and 7 April 2020 in one of the biggest COVID-19-dedicated hospitals showed that of the 169 patients hospitalized with COVID-19, 24.3% had developed ARDS [19].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence of Acute Respiratory Distress Syndrome (ARDS) and Outcomes in Hospitalized Patients with COVID-19—A Study Based on Data from the Polish National Hospital Register

Gujski

Jankowski

Rabczenko

et al. 2022

Viruses

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Acute respiratory distress syndrome (ARDS) is a serious complication of COVID-19. This study aimed to evaluate the prevalence of ARDS among patients hospitalized with COVID-19 in Poland as well as to characterize clinical outcomes in patients hospitalized with COVID-19-associated ARDS. This is a retrospective, secondary analysis of epidemiological data from 116,539 discharge reports on patients hospitalized with COVID-19 in Poland between March and December 2020. The overall prevalence of ARDS was 3.6%, respectively 2.9% among females, and 4.4% among males (p < 0.001). Of the 4237 patients hospitalized with COVID-19-associated ARDS, 3764 deaths were reported (88.8%). Participants aged 60 years and over had more than three times higher odds of COVID-19-associated ARDS. Men had higher odds of COVID-19-associated ARDS than women (OR = 1.55; 95% CI: 1.45–1.65; p < 0.001). Patients with COVID-19 and diabetes had higher odds of COVID-19-associated ARDS (OR = 1.16; 95% CI: 1.03–1.30; p = 0.01). Among patients with COVID-19-associated ARDS, older age, male sex (OR = 1.27; 95% CI: 1.03–1.56; p = 0.02), and presence of cardiovascular diseases (OR = 1.26; 95% CI: 1.00–1.59; p = 0.048) were significantly associated with the risk of in-hospital death. Among patients hospitalized with COVID-19 in Poland, the prevalence of ARDS was relatively low, but the in-hospital mortality rate in patients with COVID-19-associated ARDS was higher compared to other EU countries.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prevalence of Acute Respiratory Distress Syndrome (ARDS) and Outcomes in Hospitalized Patients with COVID-19—A Study Based on Data from the Polish National Hospital Register

Gujski

Jankowski

Rabczenko

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…A retrospective analysis of data from Wuhan showed that the MEWS was accurate in predicting in-hospital mortality in elderly patients with SARS-CoV-2 infection [ 46 ]. A small Polish study also showed that the MEWS predicted a severe course of SARS-CoV-2 infection [ 47 ]. The MEWS, which appears to be reliable and easy to assess, was found to be useful in predicting neurological worsening in a cohort of more than 7000 neurocritically ill patients with COVID-19 [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

et al. 2022

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We aimed to search whether neurological symptoms or signs (NSS) and the MEWS (Modified Early Warning Score) score were associated with in-hospital mortality or oxygen requirement during the first 14 days of hospitalization in COVID-19 patients recruited at the University Hospital in Krakow, Poland. The detailed clinical questionnaires on twenty NSS were either filled out by patients prospectively or retrospectively assessed by neurologists based on daily medical records. NSS were considered high or low-risk if they were associated with increased or decreased mortality in the univariable analysis. This cohort study included 349 patients with COVID-19 (median age 64, interquartile range (51–77), women 54.72%). The presence of high-risk NSS (decreased level of consciousness, delirium, seizures, and symptoms of stroke or transient ischemic attack) or its combination with the absence of low-risk NSS (headache, dizziness, decreased mood, and fatigue) increased the risk of in-hospital mortality in SARS-CoV-2 infection 3.13 and 7.67-fold, respectively. The presence of low-risk NSS decreased the risk of in-hospital mortality in COVID-19 patients more than 6-fold. Death in patients with SARS-CoV-2 infection, apart from NSS, was predicted by older age, neoplasm, and higher MEWS scores on admission. High-risk NSS or their combination with the absence of low-risk NSS increased the risk of oxygen requirement during hospitalization in COVID-19 patients 4.48 and 1.86-fold, respectively. Independent predictors of oxygen therapy during hospitalization in patients with SARS-CoV-2 infection were also older age, male sex, neoplasm, and higher MEWS score on admission.

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“…It should be stressed that, according to the literature on the subject, the presence of comorbidities is a significant risk factor for in-hospital mortality from COVID-19. Many authors emphasize that patients with diabetes, renal failure, heart failure, COPD, and history of stroke or cancer have a higher risk of mortality [ 47 , 52 – 60 ].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warning Score in 5127 Patients with COVID-19 Admitted to an Emergency Department in Poland Between March 2020 and April 2021

et al. 2022

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Background COVID-19, a disease caused by SARS-CoV-2, has posed a threat to global public health. This retrospective study of 5127 patients with COVID-19 admitted to an Emergency Department in Poland between March 2020 and April 2021 aimed to identify risk factors for severe disease and mortality using the modified early warning score (MEWS). Material/Methods The study was based on a retrospective analysis of patients with SARS-CoV-2 infection admitted to the Emergency Department between March 2020 and April 2021. A total of 5127 cases were included in the final analysis. Identifying the group of high-risk patients with COVID-19 was determined based on the MEWS score. Results Most of the patients studied were male (53.38%). The in-hospital mortality rate among the patients was 21.53%. The factors associated with the risk of in-hospital mortality from COVID-19 were age (>60 years, hazard ratio [HR]=2.27, P <0.001), comorbidities (cancer, HR=1.39, P =0.005; heart failure, HR=1.31, P =0.009; renal failure, HR=1.37, P =0.004), higher MEWS score (MEWS ≥5, HR=1.43, P <0.001), higher percentage of lung parenchyma affected (>50%, HR=2.10, P =0.001), and higher respiratory rate (>24 breaths per min, HR=2.10, P <0.001). Conclusions This study produced real-world data of risk factors for mortality from COVID-19 and the use of the MEWS for a faster identification of patients with COVID-19 requiring more intensive medical care.

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A Clinical Profile and Factors Associated with Severity of the Disease Among Polish Patients Hospitalized Due to COVID-19—An Observational Study

Cited by 9 publications

References 39 publications

The Prevalence of Acute Respiratory Distress Syndrome (ARDS) and Outcomes in Hospitalized Patients with COVID-19—A Study Based on Data from the Polish National Hospital Register

The Prevalence of Acute Respiratory Distress Syndrome (ARDS) and Outcomes in Hospitalized Patients with COVID-19—A Study Based on Data from the Polish National Hospital Register

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warning Score in 5127 Patients with COVID-19 Admitted to an Emergency Department in Poland Between March 2020 and April 2021

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