A clinical procedure to predict the value of temporary occlusion therapy in keratoconjunctivitis sicca

Farrell, J.; Patel, Sudi; Grierson, D. G.; Sturrock, R D

doi:10.1046/j.1475-1313.2003.00081.x

Cited by 43 publications

(42 citation statements)

References 19 publications

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“…17 We found that the tear menisci returned to near normal levels by 1 day after occlusion. Similar results were reported by Farrell et al 38 and Uchida et al 39 These data indicate insufficient baseline tear volumes in the symptomatic subjects whether or not they wore lenses. Punctal occlusion reduces tear drainage and thereby increases the tear meniscus volume.…”

Section: Discussionsupporting

confidence: 89%

Effect of Punctal Occlusion on Tear Menisci in Symptomatic Contact Lens Wearers

Wang

Shen

et al. 2012

Cornea

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Section: Discussionsupporting

confidence: 89%

Effect of Punctal Occlusion on Tear Menisci in Symptomatic Contact Lens Wearers

Wang

Shen

et al. 2012

Cornea

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“…The one study 19 that reported on the outcomes of artificial tear use indicated nonstatistically significant improvement. Three studies 17,19,21 reported improvement in tear break-up time with the plugs in place. On the basis of the limited findings of this assessment, the dissolving plugs seem to be effective in short-term reduction of symptoms and signs of dry eyes.…”

Section: Efficacymentioning

confidence: 99%

Safety and Efficacy of Lacrimal Drainage System Plugs for Dry Eye Syndrome

et al. 2015

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“…The unit of randomization for the included studies was the participant for 11 studies (Altan-Yaycioglu 2005;Chen 2010;Farrell 2003; Kaido 2012;Nava-Castaneda 2003; Qiu 2012; Qiu 2013; Rabensteiner 2013; Roberts 2007;Tsifetaki 2003; Yung 2012), the eye for 5 studies (Brissette 2015; Burgess 2008; Lowther 1995; Mansour 2007;Slusser 1998), and was unclear for 2 studies (Feng 2011; Zhou 2016;).…”

Section: Resultsmentioning

confidence: 99%

“…The unit of analysis was the eye for 7 studies (Brissette 2015;Feng 2011; Kaido 2012; Lowther 1995; Mansour 2007;Qiu 2013; Slusser 1998) although the study investigators did not discuss whether the analyses accounted for the correlation between eyes of a participant. The unit of analysis was unclear for the remaining 8 studies (Altan-Yaycioglu 2005; Burgess 2008; Chen 2010; Farrell 2003;Nava-Castaneda 2003; Qiu 2012; Yung 2012; Zhou 2016). …”

Section: Resultsmentioning

confidence: 99%

“…There was no mention of concomitant artificial tear use in the Altan-Yaycioglu 2005; Chen 2010; Farrell 2003; Kaido 2012; Lowther 1995; Mansour 2007; Nava-Castaneda 2003; Slusser 1998 studies. The objective in the Feng 2011, Qiu 2012, Qiu 2013, and Zhou 2016 studies was to compare artificial tears to punctal plugs so only participants assigned to the artificial tear group received this treatment.…”

Section: Resultsmentioning

confidence: 99%

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Punctal occlusion for dry eye syndrome

Ervin

Law

Pucker

2017

Cochrane Database of Systematic Reviews

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Background Dry eye syndrome is a disorder of the tear film that is associated with symptoms of ocular discomfort. Punctal occlusion is a mechanical treatment that blocks the tear drainage system in order to aid in the preservation of natural tears on the ocular surface. Objectives To assess the effects of punctal plugs versus no punctal plugs, different types of punctal plugs, and other interventions for managing dry eye. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 11), MEDLINE Ovid (1946 to 8 December 2016), Embase.com (1947 to 8 December 2016), PubMed (1948 to 8 December 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 8 December 2016), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com; last searched 18 November 2012 - this resource is now archived), ClinicalTrials.gov (www.clinicaltrials.gov; searched 8 December 2016), and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en; searched 8 December 2016). We did not use any date or language restrictions in the electronic searches for trials. We also searched the Science Citation Index-Expanded database and reference lists of included studies. The evidence was last updated on 8 December 2016 Selection criteria We included randomized and quasi-randomized controlled trials of collagen or silicone punctal plugs in symptomatic participants diagnosed with aqueous tear deficiency or dry eye syndrome. Data collection and analysis Two review authors independently assessed trial quality and extracted data. We contacted study investigators for additional information when needed. Main results We included 18 trials (711 participants, 1249 eyes) from Austria, Canada, China, Greece, Japan, Mexico, Netherlands, Turkey, the UK, and the USA in this review. We also identified one ongoing trial. Overall we judged these trials to be at unclear risk of bias because they were poorly reported. We assessed the evidence for eight comparisons. Five trials compared punctal plugs with no punctal plugs (control). Three of these trials employed a sham treatment and two trials observed the control group. Two trials did not report outcome data relevant to this review. There was very low-certainty evidence on symptomatic improvement. The three trials that reported this outcome used different scales to measure symptoms. In all three trials, there was little or no improvement in symptom scores with punctal plugs compared with no punctal plugs. Low-certainty evidence from one trial suggested less ocular surface staining in the punctal plug group compared with the no punctal plug group however this difference was small and possibly clinically unimportant (mean difference (MD) in fluorescein staining score -1.50 points, 95% CI -1.88 to -1.12; eyes = 61). Similarly there was a small difference in tear film stability with people in the punctal plug group having more stabili...

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A clinical procedure to predict the value of temporary occlusion therapy in keratoconjunctivitis sicca

Abstract: Collagen plugs improved tear status in the aqueous deficient dry eyes. Occluding both upper and lower puncta with temporary collagen plugs offers no practical beneficial gain compared with occluding just the lower punctum.

Cited by 43 publications

References 19 publications

Effect of Punctal Occlusion on Tear Menisci in Symptomatic Contact Lens Wearers

Effect of Punctal Occlusion on Tear Menisci in Symptomatic Contact Lens Wearers

Safety and Efficacy of Lacrimal Drainage System Plugs for Dry Eye Syndrome

Punctal occlusion for dry eye syndrome

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