A Clinical Evaluation of Biphasic Calcium Phosphate Alloplast with and without a Flowable Bioabsorbable Guided Tissue Regeneration Barrier in the Treatment of Mandibular Molar Class II Furcation Defects

Kini, Vineet; Nayak, Deepak M; Uppoor, Ashita

doi:10.5005/jp-journals-10024-1817

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…This nding has evidences from the literature showing, although limited, a mean PPD reduction by using HA/ β-TCP + GTR compared to monotherapy in management of furcation defects. 22,23 Similarly, statistically signi cant clinical attachment gain of 3 ± 1.12 mm was seen in HA/β-TCP + GTR group compared to sticky bone group 2 ± 0.85 mm at 6 months (mean CAL gain-1 ± 1.27; p < 0.05).These results are comparable with ndings stated in a literature where HA/β-TCP along with PLA-PGA membrane 23 ,collagen membrane 24 in class II furcation type defects reported a signi cant CAL gain after 6 months. Placement of a PLA-PGA membrane over DFDBA as a therapeutic modality in furcation defects had also indicated regenerative potential.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of effectiveness of concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) with hydroxyapatite reinforced beta tricalcium phosphate and bioabsorbable membrane in treatment of class ii furcation defects -A clinical study

Baliga¹,

Dhadse²,

Chimote³

et al. 2020

Preprint

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Aim - To compare the effectiveness of concentrated growth factors enriched bone graft matrix (Sticky bone) with hydroxyapatite reinforced Beta TCP and bioabsorbable membrane in treatment of class II furcation defects.Method - Total 24 patients with class II furcation defects were included in the study. The parameters recorded were plaque index (PI), papillary bleeding score (PBI), horizontal probing depth (HPD), vertical probing pocket depth (V-PPD), relative clinical attachment level (R-CAL), relative gingival marginal level(R-GML) on the day of surgery and after 6 months. Results- Comparison between mean PPD reduction between groups at 6 months indicated remarkable reduction in β-TCP + GTR group by 0.83 ± 0.93mm. Similarly, mean R-CAL gain at 6 months indicated notable gain in β-TCP + GTR group by 1 ± 1.27 mm. The mean gain of R-GML (0.25 ± 1.13 mm)and HPD reduction (0.16 ± 1.02 mm)between groups at 6 months showed no statistical significance.Conclusion –Sticky bone group showed remarkable improvement from baseline in measured clinical parameters. Percentage of defects converted to class I from class II were higher in sticky bone group (83.3%) compared to HA/β-TCP + GTR group (66.6%) showed regenerative potential which can be compared to combination therapy.

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of effectiveness of concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) with hydroxyapatite reinforced beta tricalcium phosphate and bioabsorbable membrane in treatment of class ii furcation defects -A clinical study

Baliga¹,

Dhadse²,

Chimote³

et al. 2020

Preprint

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“…It was observed by Ignjatovic et al 327 treatment of mandibular molar class-II furcation defects. 328 Bagheri et al 329 fabricated 3D porous scaffolds via a digital light process to achieve 70% porosity of pore size 600 μm. The optimum BCP content was 22.5 wt% in PLLA, which preserves good mechanical properties even during degradation and improves hydrophilicity.…”

Section: Biphasic Calcium Phosphate (Bcp)mentioning

confidence: 99%

“…It was observed by Ignjatovic et al 327 that BCP/PLLA (20/80 [w/w]) can easily dissolved in CHCl 3 , Ethyl acetate, dioxane and Tetrahydrofuran. BCP particles blended with PLGA using compatibilizer N‐Methyl‐2‐pyrrolidone promote guided tissue regeneration and support the treatment of mandibular molar class‐II furcation defects 328 . Bagheri et al 329 fabricated 3D porous scaffolds via a digital light process to achieve 70% porosity of pore size 600 μm.…”

Section: Bioresorbable Ceramicsmentioning

confidence: 99%

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Srivastava,

Bhati,

Singh

et al. 2024

Polymer Engineering & Sci

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Poly(lactic acid) (PLA) is one of the most promising biopolymers extensively used in food, packaging, medical and pharmaceutical industries. It is due to favorable physicochemical properties, in‐situ hydrolytic degradation and well‐established processing parameters. However, in medical engineering applications, PLA shows some drawbacks like low cell adhesion, biological inertness, slow degradation rate and high acid inflammation. These shortcomings of pure PLA could be addressed by blending it with other bioresorbable materials and compatibilizers. This review provides comprehensive information on different PLA composites in the field of tissue engineering, implants, injury management and drug delivery systems. The PLA‐based composites are divided into four parts: PLA/polymer, PLA/metal, PLA/ceramic, and PLA/nanoparticles. It also investigates various synthesis process, role of different compatibilizers, in vitro studies and their in vivo applications.Highlights Review the trends of bioresorbable PLA blends/composites. Extensively focused on PLA blend with polymer, metal, ceramic, and nanoparticles. Role of reinforcement and compatibilizer to overcome shortcomings of PLA implant. Highlights advantages, limitations, and properties of different types of PLA implants. Discuss various clinical applications and future of PLA blends/composite scaffolds.

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“…The wide range of applications of alloplasts underlines their importance in the dental field of today: for coatings to stabilize implants, filling defects in oral and maxilla reconstructions, augmentations, and classical reconstructions of periodontal, periapical, or endodontic surgery. 6 7 8 9 10 11 Synthetic bone grafts have many beneficial qualities, including no risks of disease transmission, unlimited supply, biocompatibility, lower morbidity, and predictability. 1 7 9 The biological performance of alloplastic biomaterials depends on many factors such as chemical composition, morphology (for example, granule size, porosity, crystallinity), or mechanical stability.…”

Section: Introductionmentioning

confidence: 99%

Prospective Clinical Study with New Materials for Tissue Regeneration: A Study in Humans

et al. 2022

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Objective This study was performed to evaluate the clinical, radiographic, and histomorphometric outcomes of novel bone grafting materials and dental membranes and to compare the results with current data from the literature. Materials and Methods New synthetic bone substitutes, consisting of biphasic calcium phosphate in the ratio of 60% hydroxyapatite and 40% β-tricalcium phosphate, were applied in bony defects and covered by either a novel synthetic poly(lactic-co-glycolic) acid (PLGA) or porcine collagen membrane. A sample of 51 biomaterials was placed in a total of 20 patients during different surgical protocols. Implants were simultaneously inserted, and in the case of sinus floor elevations 6 months later. Pre- and postoperative cone-beam computed tomographies were taken. Bone biopsies were harvested from augmented sides and processed for histomorphometric evaluation. Statistical Analysis Averages and ranges were calculated for the percentage of newly formed bone, residual biomaterial, and connective tissue. Data were submitted to analyze the radiological mean differences in length, width, and density. Paired t-tests were deployed for the analysis of differences within each group between the baseline (preoperative) and the final (postoperative) measurements. Results The mean bone gain in length and width were 0.96 ± 3.33 mm (+27.59%) and 1.22 ± 1.87 mm (+30.48%), respectively. The bone density was increased by a factor of 4, reaching an average of 387.47 ± 328.86 HU. Histomorphometric evaluations revealed new bone formation of 41.44 ± 5.37%, residual biomaterial of 24.91 ± 7.31%, and connective tissue of 33.64 ± 4.81%. The mean healing period was 8.32 ± 3.00 months. Conclusions Data from this study confirmed the suitability of the tested materials in dental surgery. The biomaterials may be recommended for various clinical procedures. A satisfactory level of increase of new bone was reported in augmented sides. No significant differences were observed between the tested membranes. PLGA membranes might be superior to collagen membranes for their easier handling.

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A Clinical Evaluation of Biphasic Calcium Phosphate Alloplast with and without a Flowable Bioabsorbable Guided Tissue Regeneration Barrier in the Treatment of Mandibular Molar Class II Furcation Defects

Abstract: It was concluded that the combination technique of BCP alloplast with a flowable bioabsorbable GTR barrier led to better results in regard to defect bone fill as compared with when the BCP alloplast alone was used.

Cited by 11 publications

References 12 publications

Comparative evaluation of effectiveness of concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) with hydroxyapatite reinforced beta tricalcium phosphate and bioabsorbable membrane in treatment of class ii furcation defects -A clinical study

Comparative evaluation of effectiveness of concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) with hydroxyapatite reinforced beta tricalcium phosphate and bioabsorbable membrane in treatment of class ii furcation defects -A clinical study

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Prospective Clinical Study with New Materials for Tissue Regeneration: A Study in Humans

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