A clinical double-blind trial of topical haloprogin and miconazole against superficial fungal infections

Clayton, Yvonne M.; Gange, Richard W.; Macdonald, D.M.; Carruthers, Jean

doi:10.1111/j.1365-2230.1979.tb01592.x

Cited by 20 publications

(8 citation statements)

References 21 publications

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“…Miconazole was superior to placebo, and efficacy was similar to clotrimazole 1%, haloprogin 1% and sulconazole 1% (no P ‐values) . Overall, mycological cure ranged from 81% to 100%; with 96%–100% mycological cure for infants with diaper dermatitis and 81%–100% for adults with Candida at various body sites .…”

Section: Resultsmentioning

confidence: 98%

“…Overall, 41 articles investigated topical therapy for cutaneous candidiasis including 2711 patients in 35 RCTs (LE: 1B) and seven prospective blinded or open‐label trials (LE: 2B), of which one article reported two trials in the same article (LE: 1B and 2B) (Table ). In total, 17 different single‐drug and four combination therapies were investigated including clotrimazole (12 studies, LE: 1B or 2B), nystatin (ten studies, LE: 1B or 2B), miconazole (eight studies, LE: 1B), halcinonide–neomycin–amphotericin B (three studies, LE: 1B), ciclopirox (two studies, LE: 1B and 2B), haloprogin (two studies, LE: 1B), halcinonide–neomycin–nystatin (two studies, LE: 1B), naftifine (two studies, LE: 1B), sulconazole (two studies, LE: 1B), mupirocin (two studies, LE: 1B or 2B) and a number of drugs tested in a single study (Table ). In 50% of the studies, the type of Candida was specified by microscopy and/or culture and the majority recorded C. albicans , whereas three studies also found a few patients with C. parapsilosis or C. tropicalis .…”

Section: Resultsmentioning

confidence: 99%

“…In total, eight studies considered topical miconazole . Four studies (LE: 1B) investigated 1–4 weeks of topical miconazole 2% twice daily for all body areas in adults (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…In total, eight studies considered topical miconazole . Four studies (LE: 1B) investigated 1–4 weeks of topical miconazole 2% twice daily for all body areas in adults (Table ). Three studies (LE: 1B) treated diaper dermatitis in infants for 1–2 weeks, while one study (LE: 1B) investigated prophylactic once‐daily 0.75% miconazole soap vs. placebo for 4 weeks in elderly with Candid a intertrigo …”

Section: Resultsmentioning

confidence: 99%

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Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Taudorf

Jemec

Hay

et al. 2019

Acad Dermatol Venereol

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Cutaneous candidiasis is a common skin disease, and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence-based topical and systemic treatment strategies remain unclear. Thus, the aim of this review was to summarize efficacy and adverse effects of topical and oral therapies for cutaneous candidiasis in all age groups. Two individual researchers searched PubMed and EMBASE for 'cutaneous candidiasis' and 'cutaneous candidiasis treatment', 'intertrigo', 'diaper dermatitis' and 'cheilitis'. Searches were limited to 'English language', 'clinical trials' and 'human subjects', and prospective clinical trials published in abstracts or articles were included. In total, 149 studies were identified, of which 44 were eligible, comprising 41 studies of 19 topical therapies and four studies of three systemic therapies for cutaneous candidiasis. Topical therapies were investigated in infants, children, adolescents, adults and elderly, while studies of systemic therapies were limited to adolescents and adults. Clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated similar efficacy with complete cure rates of 73%-100%. Single-drug therapy was as effective as combinations of antifungal, antibacterial and topical corticosteroid. Four studies investigated systemic therapy, and oral fluconazole demonstrated similar efficacy to oral ketoconazole and topical clotrimazole. Limitations to this review were mainly that heterogeneity of studies hindered meta-analyses. In conclusions, clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated equal good efficacy and mild adverse effects similar to combinations of antifungal, antibacterial and topical corticosteroids. Oral fluconazole was as effective as topical clotrimazole and is the only commercially available evidence-based option for systemic treatment of cutaneous candidiasis.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

“…In total, eight studies considered topical miconazole . Four studies (LE: 1B) investigated 1–4 weeks of topical miconazole 2% twice daily for all body areas in adults (Table ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous candidiasis – an evidence‐based review of topical and systemic treatments to inform clinical practice

Taudorf

Jemec

Hay

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…This difference was not statistically significant. Another clinical study comparing haloprogin with miconazole recorded no significant superiority for either compound when cure was assessed by negative culture results (Clayton et al, 1979).…”

Section: Discussionmentioning

confidence: 99%