“…Of the included studies, 55% were prospective 18,[20][21][22][23]26 and 45% were retrospective. 24,25,[27][28][29] Sensitivity was calculated from 61 studies that reported on the frequency of clinical signs in a cohort of patients with DCM. 10, For KQ2, the search identified 5 studies that evaluated the association between various clinical signs and disease severity as measured by the JOA (n = 3), 32,35,88 Nurick (n = 2), 20,88 mJOA (n = 1), 36 European Myelopathy Score (EMS) (n = 1), 88 Prolo Score (n = 1) 88 and Cooper Myelopathy Scale (CMS) (n = 1).…”