A Clinical Assessment of Nine Pregnancies Obtained by in Vitro Fertilization and Embryo Transfer

Wood, Carl; Trounson, Alan; Leeton, John; Talbot, John Mc.; Buttery, Beresford; Webb, Janice; Wood, Jessica; Jessup, D. S. D.

doi:10.1097/00006254-198108000-00021

Cited by 6 publications

(6 citation statements)

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“…Since the early success of in-vitro fertilization and embryo transfer in the human (Edwards et al, 1980;Lopata et al, 1980;Wood et al, 1981), a large number of clinical units using the techniques has been established worldwide, offering a service to infertile couples.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of glucose by human embryos

Wales¹,

Whittingham²,

Hardy³

et al. 1987

Reproduction

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Glucose turnover, as measured by CO2 production, lactate accumulation and carbon incorporation from [U-14C]glucose as sole energy substrate, was low on the 2nd day of culture of human embryos resulting from in-vitro fertilization but above that of unfertilized oocytes. In general, all parameters of metabolism increased substantially during the following 2 days of development but the rate of increase in lactate production was greater than that of CO2, especially between Days 3 and 4. Within developing embryos, no correlation was evident between the metabolic turnover of glucose and the method of patient stimulation, the morphological quality of embryos or the apparent rate of cleavage in culture. The results indicate that, before Day 3 of development, glucose is not effective as an energy source for the human embryo because of a blockade to glycolysis similar to that in mouse embryos.

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Section: Introductionmentioning

confidence: 99%

Metabolism of glucose by human embryos

Wales¹,

Whittingham²,

Hardy³

et al. 1987

Reproduction

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“…When Louise Brown, the world's first “test‐tube baby”, was born in the United Kingdom in 1978, 1 there was worldwide enthusiasm about the great advances in reproductive medicine. When Australia followed with a series of in‐vitro fertilisation (IVF) pregnancies and births in 1981, 2 , 3 this enthusiasm swept Australia. Nevertheless, there were some vocal critics of the reproductive revolution who demanded that research on IVF be banned 4…”

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confidence: 99%

Community attitudes to assisted reproductive technology: a 20‐year trend

Kovàcs

Morgan

Wood³

et al. 2003

Medical Journal of Australia

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Objective: To review the results of opinion polls on community attitudes to in‐vitro fertilisation (IVF) and other aspects of assisted reproductive technology over a 20‐year period. Design, setting and participants: Fourteen Australia‐wide interview surveys that included questions relating to IVF were carried out between July 1981 and November 2001 as part of regular Morgan polls of community attitudes on various topics. Each survey involved about 1000 respondents drawn from randomly selected “cluster points” in urban and rural locations. Main outcome measures: The proportion of people who approved or disapproved of various aspects of IVF treatment. Results: Support for IVF to help infertile married couples increased from 77% in 1981 to 86% in 2001. Approval for IVF procedures being supported by Medicare funding rose from 70% in 1981 to 79% in 2000. Conclusions: Community approval of the use of IVF to treat infertility has risen significantly in Australia over the past 20 years.

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“…13,19,21,65,95 Although surgical transfer through the uterine wall is the routine procedure in animals and lower primates, 136 the transcervical nonsurgical transfer is the practice in human IVF. In cattle cervical transfer results in increased uterine activity, 137 but pretreatment of patients with antiprostaglandins 138 and progesterone 121,138 to reduce uterine contractility did not seem to affect success rates. A variety of catheters and introducers have been developed for the procedure.…”

Section: Embryo Transfermentioning

confidence: 97%