A clinical and electron microscopic study of a calcifying epithelial odontogenic tumour

Mainwaring, A. R.; Ahmed, Akhter U.; Hopkinson, John; Anderson, Patricia F

doi:10.1136/jcp.24.2.152

Cited by 33 publications

(14 citation statements)

References 12 publications

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“…It was earlier believed that CEOT originated from dental lamina, reduced enamel epithelium, or from the basal cells of the oral epithelium. It has also been proposed that CEOT arises from cells of the stratum intermedium of the dental organ by electron microscopic and histochemical evidence 6 …”

Section: Discussionmentioning

confidence: 99%

“…It has also been proposed that CEOT arises from cells of the stratum intermedium of the dental organ by electron microscopic and histochemical evidence. 6 The incidence of CEOT varies between 0.4% and 3% of all odontogenic tumours. 5 CEOT can occur at any age; however, it is most often seen between 30 and 50 years of age, with no sex predilection.…”

Section: Discussionmentioning

confidence: 99%

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Cystic variant of calcifying epithelial odontogenic tumor

Channappa

Krishnapillai

Rao

2011

J of Invest & Clin Dent

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The calcifying epithelial odontogenic tumor is a rare benign odontogenic neoplasm of the jaw. Clinically, calcifying epithelial odontogenic tumor manifests as an intraosseous lesion (central type) in the majority of cases (95%). Extraosseous or peripheral lesions account for less than 5% of cases. Calcifying epithelial odontogenic tumor can be associated with an impacted tooth and give a radiographic simulation of dentigerous cyst. Most calcifying epithelial odontogenic tumors are solid in nature, histopathologically, and might have few cyst-like spaces within them. However, a true cystic calcifying epithelial odontogenic tumor is a rare possibility. We describe a case of a true cystic variant of calcifying epithelial odontogenic tumor in a 30-year-old male, which to our knowledge, is only the second reported case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cystic variant of calcifying epithelial odontogenic tumor

Channappa

Krishnapillai

Rao

2011

J of Invest & Clin Dent

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“…Enzyme histochemical studies have revealed strong alkaline phosphatase activity in the tumor cells (7)(8)(9). The homogenous acellular materials have been variably described as either amyloid-like (10)(11)(12)(13)(14)(15)(16)(17)(18) or not amyloid (5)(6)(7)(19)(20)(21). Electron microscopic studies have detected fibrillar structures in the acellular material that differs from amyloid (22,7,20) and resemble epithelial fibrillar proteins such as keratin (19).…”

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confidence: 99%

Immunohistochemical localization of intermediate filament proteins in calcifying epithelial odontogenic tumors

Mori

Tatemoto

Yamamoto

et al. 1988

J Oral Pathology Medicine

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Three calcifying epithelial odontogenic tumors (CEOT) were examined immunohistochemically. The localization of intermediate filaments was characterized through the use of polyclonal anti‐keratin antiserum (TK which detects 41–65 kd keratins), 2 monoclonal keratin antibodies (PKK1 specific for the 44, 46, 52 & 53 kd keratins and KL1, specific for the 55–57 kd keratins) and monoclonal antibodies for vimentin and desmin. The tumor epithelial cells were slightly positive or negative for PKK1 detectable keratins, but slightly to strongly positive for KL1 and TK antibodies. Tumor epithelium was slightly positive for vimentin but negative for desmin. The tumor foci were composed of both dark‐staining and pale‐staining cells; the former had a more intense reaction with KL1 and TK antibodies than the latter. Homogeneous acellular material was either PAS‐positive or negative, with or without calcification, and keratin‐negative.

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“…They suggested that the 5 nm fine filaments represented basal lamina rather than amyloid, but could not exclude the possibility of the 11 nm fibrils being amyloid. Mainwaring et al (1971) also regarded the fibrils in CEOT as being smaller than classic amyloid fibrils. Chaudhry et al (1972) observed that they consisted of randomly oriented fibrillar material measuring from 5 nm-15 nm.…”

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confidence: 99%

The nature of the amyloid‐like material in a calcifying epithelial odontogenic tumour: an ultrastructural study

El‐Labban

Lee

Kramer

et al. 1983

J Oral Pathology Medicine

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An ultrastructural study was carried out to investigate the nature of an eosinophilic material, having the staining properties of amyloid, in a case of calcifying epithelial odontogenic tumour. At the electron‐microscopical level, the eosinophilic masses consisted of two types of structure which are probably related. The first type appeared as sheets of fine filaments measuring 10–12 nm in diameter. The second type was in the form of aggregates of lamina densa fragments, probably secreted by the tumour epithelium. These fragments appeared to undergo some loss of electron density and became degraded into fine filaments, having similar thickness and electron density to those forming the filamentous masses. It is concluded from this study that the fine filamentous material is a form of amyloid which results from degradation of lamina densa material.

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A clinical and electron microscopic study of a calcifying epithelial odontogenic tumour

Cited by 33 publications

References 12 publications

Cystic variant of calcifying epithelial odontogenic tumor

Cystic variant of calcifying epithelial odontogenic tumor

Immunohistochemical localization of intermediate filament proteins in calcifying epithelial odontogenic tumors

The nature of the amyloid‐like material in a calcifying epithelial odontogenic tumour: an ultrastructural study

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