A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice

Antiadipogenic effects of a standardized quassinoids‐enriched fraction and eurycomanone from Eurycoma longifolia

“…Interestingly, our findings also revealed that weight gain was prevented in mice without calorie intake reduction. These results are consistent with other previous studies that showed weight gain in animal models could be prevented without food intake suppression (Beg et al, ; Inafuku et al, ; Sharma, Kim, Kim, Park, & Rhyu, ; Song et al, ). This then suggests that SQEL may regulate body weight gain by boosting calorie expenditure via a mechanism that has yet to be determined.…”

“…Hypertriglyceridemia and hypercholesterolemia are associated with increased risk for obesity as there is a significant correlation between impaired lipid metabolism and obesity (Eisinger et al, ; Subramanian & Chait, ). Previously, it was shown that C57BL/6J mice on obesogenic diet had elevated levels of serum triglycerides and cholesterol compared with those on ND (Beg et al, ; Song et al, ). However, in the present study, serum total cholesterol but not triglyceride levels were significantly higher in mice fed with HFD compared with those on ND.…”

“…Several reports have shown the correlation of adipogenesis and the development of obese condition (Nishimura et al, ; Spiegelman & Flier, ). Phytochemicals including curcumin, rutin, and clerodane diterpene have been shown to inhibit the progression of adipogenesis in 3T3‐L1 cells as well as obesity in C57BL/6J mouse model (Beg et al, ; Choi, Park, Choi, & Lee, ; Ejaz, Wu, Kwan, & Meydani, ). C57BL/6J mice fed with HFD develop features of obesity‐associated diseases including hypertriglyceridemia, hyperglycemia, insulin resistance, and hepatic steatosis suggesting that it is a suitable experimental model of metabolic syndrome (Fernandes‐Santos, Carneiro, Mendonca, Aguila, & Mandarim‐de‐Lacerda, ; Fraulob, Ogg‐Diamantino, Fernandes‐Santos, Aguila, & Mandarim‐de‐Lacerda, ).…”

Yeast with bacteriocin from ruminal bacteria enhances glucose utilization, reduces ectopic fat accumulation, and alters cecal microbiota in dietary-induced obese mice

“…20 Both of them decreased hepatic lipid accumulation. To develop a more efficacious and safe anti-obesity therapy, several phytochemicals and natural products have been evaluated.…”

“…5 In a previous study, we successfully mass-produced albusin B via a yeast expression system, 13 and named this albusin B-expressing yeast product as YB. 11,19,20 Probiotics and bacteriocins could be one of the potential agents. 13,14 YB also modulated the gut microbiota by increasing cecal Lactobacillus counts and decreasing pathogenic populations.…”