Abstract:Short-term inhalation experiments have been recently performed in rats to evaluate the biopersistence of man-made vitreous fibers ( MMVFs) . The number and size distribution of inhaled fibers in the rat lung were measured at different postexposure time points.These data were used for developing a mathematical model to describe the clearance kinetics of MMVFs in the rat lung. The model proposed a breakage scheme for long fibers during clearance. The breakage rates for different MMVFs were determined from the fi… Show more
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