A Classical Live Attenuated Vaccine for Sheep Pox

Bhanuprakash,; Bk, Indrani; Hegde, Raveendra; Mm, Kumar; Ar, Moorthy

doi:10.1023/b:trop.0000026661.88631.50

Cited by 25 publications

(11 citation statements)

References 3 publications

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“…A serological response was detected one week earlier for the inactivated vaccine group than for the live attenuated vaccine. This is in agreement with the previous studies, showing an increase in antibody titres between D7 and D21 post-vaccination and a boost of the immune response following a challenge [ 16 , 17 ]. Neverthless, the need of a booster for inactivated vaccines is usually a constraint compared to live attenuated vaccine that need only one shot.…”

Section: Discussionsupporting

confidence: 94%

Comparative innocuity and efficacy of live and inactivated sheeppox vaccines

Boumart¹,

Daouam²,

Belkourati

et al. 2016

BMC Vet Res

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BackgroundSheeppox (SPP) is one of the priorities, high-impact animal diseases in many developing countries, where live attenuated vaccines are routinely used against sheeppox virus (SPPV). In an event of an SPP outbreak, historically disease-free countries would hesitate to use of live vaccines against SPPVdue to the safety and trade reasons. Currently no killed SPPV vaccines are commercially available. In this study, we developed an inactivated Romanian SPPVvaccine and assessed its efficacy and potency in comparison with a live attenuated Romanian SPPV vaccine. Four naïve sheep were vaccinated once with the Romanian SPPV live attenuated vaccine and16 sheep were vaccinated twice with the inactivated vaccine. All sheep in the live vaccine group were included in the challenge trial, which was conducted using a highly virulent Moroccan SPPV field strain. Eight sheep of the inactivated vaccine group were challenged and the remaining sheep were monitored for seroconversion. Experimental animals were closely monitored for the appearance of clinical signs, body temperature and inflammation at the injection site. Two naïve sheep were used as unvaccinated controls.ResultsThe inactivated Romanian SPPV vaccine was found to be safe and confer a good protection, similar to the live vaccine. Specific antibodies appeared from seven days post vaccination and remained up to nine months.ConclusionThis study showed that the developed inactivated Romanian SPPV vaccine has a potential to replace attenuated vaccine to control and prevent sheep pox in disease-free or endemic countries.

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Section: Discussionsupporting

confidence: 94%

Comparative innocuity and efficacy of live and inactivated sheeppox vaccines

Boumart¹,

Daouam²,

Belkourati

et al. 2016

BMC Vet Res

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“…Immunocompromised, weak and stressed sheep are also predisposed to the disease. Besides this, ecosystem, physiography, soil types, rainfall, relative humidity and temperatures also influence the disease occurrence (Bhanuprakash et al., 2004). Although the distribution of Capripoxvirus have considerably reduced from what it was even 50 years ago, they are now re‐emerging and expanding their territory since the recent outbreaks of sheep pox or goat pox in Vietnam, Mongolia and Greece have been reported (Bowden et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

Emerging Capripoxvirus Disease Outbreaks in Himachal Pradesh, a Northern State of India

Verma

Gupta

et al. 2010

Transboundary and Emerging Diseases

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Both sheep and goat pox are contagious viral diseases and affect small ruminants and are caused by sheep pox virus and goat pox virus respectively that belong to genus Capripoxvirus of Poxviridae family. Huge economic losses emanating from the disease outbreaks are the results of the wool and hide damage, subsequent production losses and also the morbidities and mortalities associated with the disease. This communication highlights clinico-epidemiological observations from the two sheep pox and one goat pox outbreaks. Grossly, multisystemic nodular lesions, mucopurulent nasal discharges and respiratory symptoms were observed in the affected animals. The morbidity, mortality and case fatality rates were 5.18%, 2.45% and 32.37%, respectively. Histopathological, haematological, molecular and serological techniques and also isolation of virus in embryonated chicken eggs were used for the diagnosis of the diseases. The spatial distribution of the disease signifies the role of common pasturelands used for grazing the animals while temporally all three outbreaks occurred in winters and were probably associated with cold stress and fodder scarcity. This is the first recorded report of Capripoxvirus infection in recent times and it highlights the disease as one of the emerging diseases in the northern state of Himachal Pradesh in India.

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“…Morbidty of Good breeds animals is lower than bad one (Mullick,1988). Besides this, ecosystem, soil types, rainfall, and temperatures also influence the disease (Bhanuprakash et al, 2004).the most important factor was Animal mobile without Strict quarantine in the four outbreaks in Xinjiang.the secand important factor was not paying attention to the vaccine inoculation in our investgation.…”

Section: Discussionmentioning

confidence: 98%

Identification of four goatpox virus outbreaks in Xinjiang of China in 2010

Haihong

2011

Proceedings 2011 International Conference on Human Health and Biomedical Engineering

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Goat pox is contagious viral diseases of small ruminants and are caused by goat pox virus that belong to genus Capripoxvirus of Poxviridae family. The disease epidemics cause significant economic losses for sheepindustry.This communication highlights clinicoepidemiological observations from the four goat pox outbreaks in Xinjiang China in 2010. In clinical signs,fever,multisystemic nodular lesions, mucopurulent nasal discharges and respiratory symptoms were observed in the affected animals all that are goats but sheep. The morbidity, mortality and case fatality rates were 26.3% ,9.2% and 35%, respectively. pathologic anatomy,PCR techniques and also isolation of virus in Sheep original generation testicular cells were used for the diagnosis of the diseases.As results,969 bp of DNA band of P32 gene are amplificated from skin ,tongue ,lung ,liver and stomach and similarity cytopathic effect is caused in LT cell by inoculated processed materials of sick sample and Attenuated vaccian of goatpoxvirus.It concluded that the four outbreaks are affected by goatpox virus.

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A Classical Live Attenuated Vaccine for Sheep Pox

Cited by 25 publications

References 3 publications

Comparative innocuity and efficacy of live and inactivated sheeppox vaccines

Comparative innocuity and efficacy of live and inactivated sheeppox vaccines

Emerging Capripoxvirus Disease Outbreaks in Himachal Pradesh, a Northern State of India

Identification of four goatpox virus outbreaks in Xinjiang of China in 2010

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