A circadian susceptibility/resistance rhythm for potassium cyanide in male BALB/cCr mice

Bafitis, Harold; Smolensky, Michael H.; Hsi, Bartholomew P.; Mahoney, S.A.; Schectman, Tommy; Kresse, H; Powel, Susan; Dutton, Laverne

doi:10.1016/s0300-483x(78)91539-1

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…This is because there are pronounced circadian rhythms in the metabolism and excretion of toxic substances. For example, a fixed dose of cyanide (77.5mg/kg) kills 100 per cent of mice (standardized to a 24-hour light (6a.m.-6 p.m.) / dark (6 p.m.-6 a.m.) cycle] at 8 p.m. but only 30 per cent at 8 a.m. (Bafitis et al, 1978). Likewise, the cutaneous response of people allergic to histamine and house dust shows a pronounced circadian rhythm, bottoming out at about 7 a.m. and peaking 12 hours later at about 7 p.m. (McGovern, Smolensky and Reinberg, 1977).…”

Section: Combined Effects Of Shift Work and Other Occupational Hazardsmentioning

confidence: 99%

Lidando com as longas jornadas de trabalho em turnos na mineração: desafios e possíveis intervenções

Fischer¹

2018

Rev. Bras. Med. Trab.

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Section: Combined Effects Of Shift Work and Other Occupational Hazardsmentioning

confidence: 99%

Lidando com as longas jornadas de trabalho em turnos na mineração: desafios e possíveis intervenções

Fischer¹

2018

Rev. Bras. Med. Trab.

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The effects of the light-dark cycle and its inversion on the susceptibility of mice to lead acetate

Hayashi¹,

Chiba²,

Kikuchi

1987

Int J Biometeorol

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Perspectives on the relevance of the circadian time structure to workplace threshold limit values and employee biological monitoring

Smolensky

Reinberg

Sackett-Lundeen³

2017

Chronobiology International

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The circadian time structure (CTS) and its disruption by rotating and nightshift schedules relative to work performance, accident risk, and health/wellbeing have long been areas of occupational medicine research. Yet, there has been little exploration of the relevance of the CTS to setting short-term, time-weighted, and ceiling threshold limit values (TLVs); conducting employee biological monitoring (BM); and establishing normative reference biological exposure indices (BEIs). Numerous publications during the past six decades document the CTS substantially affects the disposition - absorption, distribution, metabolism, and elimination - and effects of medications. Additionally, laboratory animal and human studies verify the tolerance to chemical, biological (contagious), and physical agents can differ extensively according to the circadian time of exposure. Because of slow and usually incomplete CTS adjustment by rotating and permanent nightshift workers, occupational chemical and other contaminant encounters occur during a different circadian stage than for dayshift workers. Thus, the intended protection of some TLVs when working the nightshift compared to dayshift might be insufficient, especially in high-risk settings. The CTS is germane to employee BM in that large-amplitude predictable-in-time 24h variation can occur in the concentration of urine, blood, and saliva of monitored chemical contaminants and their metabolites plus biomarkers indicative of adverse xenobiotic exposure. The concept of biological time-qualified (for rhythms) reference values, currently of interest to clinical laboratory pathology practice, is seemingly applicable to industrial medicine as circadian time and workshift-specific BEIs to improve surveillance of night workers, in particular. Furthermore, BM as serial assessments performed frequently both during and off work, exemplified by employee self-measurement of lung function using a small portable peak expiratory flow meter, can easily identify intolerance before induction of pathology.

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A circadian susceptibility/resistance rhythm for potassium cyanide in male BALB/cCr mice

Cited by 3 publications

References 9 publications

Lidando com as longas jornadas de trabalho em turnos na mineração: desafios e possíveis intervenções

Lidando com as longas jornadas de trabalho em turnos na mineração: desafios e possíveis intervenções

The effects of the light-dark cycle and its inversion on the susceptibility of mice to lead acetate

Perspectives on the relevance of the circadian time structure to workplace threshold limit values and employee biological monitoring

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