A chromosomal abnormality in a girl with some features of Down's syndrome (mongolism)

Partial trisomy in a child with features suggesting mongolism.

“…(d) The case of Warkany and Soukup (1963) previously mentioned and the one here reported are more difficult to explairn. findings a partial trisomy seems to be present; the donor chromosome, however, remains undetected and is perhaps different in both cases.…”

Pericentric inversion in a family with a 21/22 translocation

“…The case did not remain unique for long; other cases of the same type of translocation in children with Down's syndrome were described by Warkany and Soukup (1963), Lejeune ct al. (1965) and Richards et al (1965).…”

A 21/21 tandem translocation with satellites on both long and short arms

“…As expected in cases of familial G/G translocation, random segregation of both translocated and normal G-group chromosomes leads to trisomy in some instances. Warkany andSoukup (1963), Zellweger et al (1963), and Lejeune et al (1965) have reported cases of non-familial G/G tandem translocations which apparently resulted from break-rejoin events between two No. 21 chromosomes.…”

“…Familial translocations have been reported by Soudek, Laxova, and Addmek (1968) and Cohen and Davidson (1967). A few reports of non-familial G/G tandem translocations have also appeared (Warkany and Soukup, 1963;Zellweger, Mikamo, and Abbo, 1963;Lejeune et al, 1965). Sachdeva, Wodnicki, and Smith (1971) and Vogel (1972) found a G/G tandem translocation chromosome with satellites on both the long and short arms, and identified it as a 21/21 translocation by differential staining.…”