A Cherry Seed‐Derived Spice, Mahleb, is Recognized by Anti‐Almond Antibodies Including Almond‐Allergic Patient IgE

Noble, Kyle A.; Liu, Changqi; Sathe, Shridhar K.; Roux, Kenneth H.

doi:10.1111/1750-3841.13757

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…A recent investigation showed a cherry seed-derived spice, mahleb , is recognized by anti-almond antibodies including almond-allergic patient IgE [ 25 ]. The cross-reactivity between almond and mahleb , which is prepared from the kernels of a species of cherry, should be of particular concern to almond-allergic patients and attending medical personnel.…”

Section: Prevalencementioning

confidence: 99%

Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection

Mandalari

Mackie

2018

Nutrients

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Food allergy has been on the increase for many years. The prevalence of allergy to different foods varies widely depending on type of food, frequency of consumption and geographic location. Data from the literature suggests that the prevalence of tree nut allergy is of the order of 1% in the general population. Almond is one such tree nut that is frequently eaten in many parts of the world and represents a potential allergenic hazard. Given the need to label products that contain allergens, a number of different methods of direct and indirect detection have been developed. However, in the absence of population-based threshold data, and given that almond allergy is rare, the sensitivity of the required detection is unknown and thus aims as low as possible. Typically, this is less than 1 ppm, which matches the thresholds that have been shown for other allergens. This review highlights the lack of quantitative data on prevalence and thresholds for almonds, which is limiting progress in consumer protection.

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Section: Prevalencementioning

confidence: 99%

Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection

Mandalari

Mackie

2018

Nutrients

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“…Consequently, patients sensitive to almond amandin may experience adverse reactions upon exposure to foods (for example, persipan) containing the homologous peach protein. We have recently reported cross‐reactivity of almond allergic patients’ serum IgE with P. mahaleb 11S legumin (Noble and others ). Currently, there is no analytical method available for peach or cherry kernel protein detection.…”

Section: Resultsmentioning

confidence: 90%

Comparison of Laboratory‐Developed and Commercial Monoclonal Antibody‐Based Sandwich Enzyme‐Linked Immunosorbent Assays for Almond (Prunus dulcis) Detection and Quantification

Liu

Chhabra

Zhao

et al. 2017

Journal of Food Science

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“…This later interpretation is not incongruous with the findings of Noble et al, who have shown that IgE present in the serum of an almond allergic individual exhibited reactivity with mahaleb, both in ELISA and in Western Blot, though in their analysis, the authors were able to show competitive binding of antibody against both targets. 13 However, cross-reactivity with nut allergens is frequently observed in the context of birch pollen allergy, 1 and elevated serum levels of birch pollen-specific immunoglobulin IgE are reported for individuals with oralallergy syndrome towards plant-derived proteins. 14 Importantly, the results of this study do not preclude the possibility of cross-reactivity as it is important to consider that the nut extracts used for the SPTs were prepared from apparent raw nut materials, and it remains plausible that roasted nut extracts would have elicited different outcomes.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Allergic Reactivity to Mahaleb (Prunus mahaleb) Spice in a Subject With Almond and Other Tree Nut Allergies

Benoit¹,

Masiri²,

Janagama³

et al. 2020

Allergy�Rhinol (Providence)

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Background Mahaleb is an aromatic spice prepared from the fruit stone of the St. Lucie Cherry that is used as a flavoring agent in traditional Turkish and Middle Eastern baking. Immunodiagnostic kits for almond, which are based on polyclonal almond-specific IgG antibodies, have been shown to demonstrate considerable cross-reactivity with mahaleb as was incidentally discovered during a cluster of allergen-related food recalls in 2015. Objective Though acute allergy to almond is somewhat common, allergies to mahaleb have not been previously documented. However, based on antigenic similarity observed with almond-specific IgG, it is predicted that mahaleb nut proteins would exhibit some level of cross-reactivity with almond-specific IgE and may therefore potentiate acute allergic symptoms in individuals with food allergy to almond. Case Presentation: Herein, we report on a 40-year old Caucasian female with longitudinal history of multiple tree nut allergies including allergy to almond, presenting with moderate pruritus and oropharyngeal swelling shortly following ingestion of mahaleb seed kernels. Methods and Results Skin-prick testing using extracts compounded from pistachio, almond, and mahaleb revealed positive wheals measuring 8, 3, and 7 mm respectfully. Indirect enzyme-linked immunosorbent assay (ELISA) using plate-bound antigens prepared from pistachio, almond, and mahaleb revealed IgG positive responses to all three targets. ELISA and Western blot analysis performed using goat anti-almond polyclonal IgG demonstrated significant cross-reactivity between almond and mahaleb, but not to pistachio. Conclusion This is the first documented case of acute allergy to mahaleb, co-occurring in the context of plural tree nut allergies, providing novel evidence that mahaleb may pose a risk to nut-allergic individuals and indicating a need for awareness of spice contamination with nut and mahaleb residues.

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A Cherry Seed‐Derived Spice, Mahleb, is Recognized by Anti‐Almond Antibodies Including Almond‐Allergic Patient IgE

Cited by 6 publications

References 29 publications

Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection

Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection

Comparison of Laboratory‐Developed and Commercial Monoclonal Antibody‐Based Sandwich Enzyme‐Linked Immunosorbent Assays for Almond (Prunus dulcis) Detection and Quantification

Case Report: Allergic Reactivity to Mahaleb (Prunus mahaleb) Spice in a Subject With Almond and Other Tree Nut Allergies

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