A chemically reduced graphene oxide–Au nanocage composite for the electrochemical detection of dopamine and uric acid

Li, Weihao; Ma, Lian; Wu, Bingxue; Zhang, Yue; Li, Zhuang

doi:10.1039/c7ay00677b

Cited by 18 publications

(4 citation statements)

References 27 publications

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“…The measurements were performed for a uric acid concentration range of 10 µM to 90 µM in KCl solution. The results showed a LOD at 0.4 µM and a quantification limit of 1.0 µM, which is comparable to other highly sensitive uric acid sensors [27,30,37,[60][61][62][63][64]. The electrode exhibited good stability and selectivity, as shown in Table 2, by performing repeated measurements in the presence of ascorbic acid (AA), dopamine (DA), glucose (G), magnesium and urea (UR).…”

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confidence: 60%

New Trends in Uric Acid Electroanalysis

Chelmea,

Badea,

Scarneciu

et al. 2023

Chemosensors

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Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide a reliable method for screening and evaluation of uric acid status. Due to the numerous categories of (bio)sensors available, choosing the appropriate one is a challenge. This study reviews the scientific information concerning the most suitable (bio)sensors for quantification of uric acid, presenting a list of sensors from the last decade, categorized by configurations and materials. In addition, this review includes a comparison of sensors according to their interference behavior and sensitivity, offering an objective perspective for identifying devices that are suitable for clinical applications.

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supporting

confidence: 60%

New Trends in Uric Acid Electroanalysis

Chelmea,

Badea,

Scarneciu

et al. 2023

Chemosensors

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“…The obtained LOD for DA detection is superior as compared to most of the reported literature (Table ). − …”

Section: Resultsmentioning

confidence: 99%

Porous Nitrogen-Doped Crumpled Graphene Nanoparticles: A Metal-Free Nanozyme for Selective Detection of Dopamine in Aqueous Medium and Human Serum

Boruah

Borthakur

Neog

et al. 2023

ACS Appl. Nano Mater.

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Accurate detection of trace analytes in biological samples is essential for medical diagnostics but usually requires complex and expensive instruments. Nanozymes, a series of nanosized systems with a catalytic activity mimicking that of peroxidase enzymes, offer a useful alternative for the design of sensing devices. In this article, we describe the synthesis of porous 3D nitrogen-doped crumpled graphene nanoparticles (CGNPs) and their use as a platform for the sensitive detection of dopamine (DA) in complex biological media such as blood serum. CGNPs were prepared by doping graphene oxide (GO) using ammonium hydroxide in a hydrothermal treatment. This procedure leads to the crumpling of GO sheets into porous sphere-like nanoparticles, with a diameter of 34 ± 10 nm. These nanoparticles with high surface area and improved electronic properties proved very active for the oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB). Our sensing device relied on the scavenging of hydroxyl radicals by DA, resulting in a turn-off effect for TMB oxidation. The system selectively detected DA with a limit of detection of 1.15 μM and a linearity range of 1 to 20 μM. The system also possessed good selectivity for DA in the presence of various interfering species, as well as in human blood serum.

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“…[154] Chemically reduced GO (CrGO) and gold nanocages (AuNCs) were employed to prepare a composite to modify GCE. [155] The combination of these two materials (CrGO@AuNCs) displayed enhanced selectivity and reproducibility. Additionally, AuNCs [152] Copyright 2018, Elsevier.…”

Section: Simultaneous Determination Of Da With Other Speciesmentioning

confidence: 99%

Graphene and Carbon Nanotube‐based Electrochemical Sensing Platforms for Dopamine

Islam

Shah

Naher

et al. 2021

Chemistry An Asian Journal

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Dopamine (DA) is an important neurotransmitter, which is created and released from the central nervous system. It plays a crucial role in human activities, like cognition, emotions, and response to anything. Maladjustment of DA in human blood serum results in different neural diseases, like Parkinson's and Schizophrenia. Consequently, researchers have started working on DA detection in blood serum, which is undoubtedly a hot research area. Electrochemical sensing techniques are more promising to detect DA in real samples. However, utilizing conventional electrodes for selective determination of DA encounters numerous problems due to the coexistence of other materials, such as uric acid and ascorbic acid, which have an oxidation potential close to DA. To overcome such problems, researchers have put their focus on the modification of bare electrodes. The aim of this review is to present recent advances in modifications of most used bare electrodes with carbonaceous materials, especially graphene, its derivatives, and carbon nanotubes, for electrochemical detection of DA. A brief discussion about the mechanistic phenomena at the electrode interface has also been included in this review.

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A chemically reduced graphene oxide–Au nanocage composite for the electrochemical detection of dopamine and uric acid

Abstract: Herein, a chemically reduced graphene oxide–Au nanocage (CRGO–AuNCs) composite was synthesized by electrostatic assembly of poly-diallyldimethylammonium chloride (PDDA)-modified CRGO and mercaptosuccinic acid (MSA)-modified Au nanocages.

Cited by 18 publications

References 27 publications

New Trends in Uric Acid Electroanalysis

New Trends in Uric Acid Electroanalysis

Porous Nitrogen-Doped Crumpled Graphene Nanoparticles: A Metal-Free Nanozyme for Selective Detection of Dopamine in Aqueous Medium and Human Serum

Graphene and Carbon Nanotube‐based Electrochemical Sensing Platforms for Dopamine

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