A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays

La, Moonwoo; Park, Sung Jea; Kim, Hyung Woo; Park, Sung Chul; Ahn, Kang-Hun; Ryew, Sungmoo; Kim, Dong Sung

doi:10.1007/s10404-012-1127-z

Cited by 50 publications

(36 citation statements)

References 38 publications

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“…A simple passive design is convenient to manufacture on a mass-production scale for fabrication purposes and is also portable, cost-effective and easy to use. La, et al [25] designed and fabricated a centrifugal serpentine micromixer (CSM) on an LOCD and compared it to an original pressure-driven serpentine micromixer (PSM). Mixing in the PSM was limited since two laminar flows within the microchannel could only be mixed through diffusion and an inertial stirring effect happening within the sharp corners of the microchannel.…”

mentioning

confidence: 99%

Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

Shamloo

Madadelahi

Akbari

2016

Chemical Engineering and Processing: Process Intensification

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Centrifugal microfluidics or the Lab on a CD (LOCD) has developed vast applications in biomedical researches and analyses. Fluid mixing is an application of the LOCD. In this paper, multiple centrifugal micromixers were simulated. Various parameters were originally presumed to have an effect on mixing performance. These parameters include inlet angle, angular velocity, cross-sectional profile, perpendicular length ratio and the number of channels in series. They were each analyzed through simulations. It was gathered that the inlet angle does not significantly affect the mixing quality. Increasing angular velocity steadily increases mixing quality for all geometries. The vertical triangular cross section gives the best mixing quality and the horizontal rectangular cross section has the worst. Also both increasing the perpendicular length ratio and adding an additional microchannel in series to the original, enhances mixing.

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mentioning

confidence: 99%

Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

Shamloo

Madadelahi

Akbari

2016

Chemical Engineering and Processing: Process Intensification

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“…Mixers in microfluidics can be classified into groups of passive and active, where the second type needs an external energy supply . Forces resulting from acoustic, dielectrophoretic, electromagnetic, electrohydrodynamic, temperature gradient, and pressure perturbations are examples of external energies used to improve mixing in active mixers …”

Section: Introductionmentioning

confidence: 99%

“…Mixers in microfluidics can be classified into groups of passive and active, where the second type needs an external energy supply. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Forces resulting from acoustic, dielectrophoretic, electromagnetic, electrohydrodynamic, temperature gradient, and pressure perturbations are examples of external energies used to improve mixing in active mixers. 17 El Moctar et al 18 studied a micromixer in which two fluids with identical viscosity and density, but different electrical properties, were injected by syringe pumps.…”

Section: Introductionmentioning

confidence: 99%

Numerical study of the effects of internal and external forces on the nanoparticle mixing in a ferrofluid flow

Hamdollahi

Aminfar

Mohammadpourfard

et al. 2019

Heat Trans. Asian Res.

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Micromixers are an essential part of microfluidic devices. Numerous studies have previously discussed improving the mixing efficiency in micromixers. In the present study, the scale analysis of different forces has been done to predict their influence on the behavior of the particles. Results show that the order of the magnitude of gravitational force is lower than other forces in this study and it is not effective. Then, in the absence of the magnetic field, the effects of different forces on the mixing of magnetic nanoparticles have been studied using the one‐way coupling method. According to the numerical results, it is observed that the Brownian force is essential for the normal behavior of nanoparticles. The thermophoretic force causes the penetration of particles into pure water, but homogeneous mixing does not occur. Finally, two methods have been introduced to improve mixing, including increasing the velocity of ferrofluid and magnetic field implementation. Both approaches make particle distribution more homogeneous. Incidentally, both of the above‐mentioned factors are useful for improving the mixing process. Using them together yields more homogeneous mixing in a shorter length of the mixing channel.

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“…[10][11][12][13][14][15] These devices enable nonprofessional technicians to perform clinical testing near patients. "Lab-on-a-disk" systems have demonstrated great potential as platforms for POC testing because of their ability to actuate low-volume liquid samples, and perform integrated sample preparation procedures on the disk through microfluidic functions, such as decanting, [16][17][18][19][20] mixing, [21][22][23][24][25][26][27] and aliquoting. 28 In addition, it is possible to use a portable diagnostic instrument similar in size to a compact disk player and an inexpensive disposable assay disk could be made by injection molding.…”

Section: Introductionmentioning

confidence: 99%

A Point-of-Care Prothrombin Time Test on a Microfluidic Disk Analyzer Using Alternate Spinning

Lin¹,

Lin²,

Yen³

et al. 2015

j nanosci nanotechnol

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In this study, we conducted a fully integrated point-of-care prothrombin time test on a microfluidic disk analyzer. The microfluidic functions integrated on the disk were capable of separating whole blood, decanting plasma, and mixing it with reagents in sequence under alternate spinning. The assay protocol was completed by alternate spinning without using microvalves or surface modification. Clinical sample tests on prothrombin time measurement were conducted by both the microfluidic disk analyzer and the reference instrument used in medical centers. The test results showed a good correlation and agreement between the two instruments.

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A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays

Cited by 50 publications

References 38 publications

Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

Numerical study of the effects of internal and external forces on the nanoparticle mixing in a ferrofluid flow

A Point-of-Care Prothrombin Time Test on a Microfluidic Disk Analyzer Using Alternate Spinning

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