A cellulosic exopolysaccharide produced from sugarcane molasses by a Zoogloea sp.

Paterson-Beedle, Marion; Kennedy, John F.; Melo, F.A.D.; Lloyd, Linda L.; Medeiros, Victor Wanderley Costa de

doi:10.1016/s0144-8617(99)00179-4

Cited by 69 publications

(54 citation statements)

References 10 publications

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“…The absence of major inflammatory response in histological findings as well as no signals of inflammatory or allergic reactions for grafting rejection for SCB group proved once again the SCB biocompatibility as described in previous works 8,9 .…”

Section: Discussionsupporting

confidence: 80%

“…The sugarcane biopolymer (SCB) shows physical and chemical characteristics suitable for prostheses manufacture since in its pure form SCB presents low toxicity, high biocompatibility, elasticity, tensile strength, flexibility and modelling capacity [8][9] SCB demonstrated proper effects on different tissues causing integration with and remodelling of soft tissues 10 . In critical bone defects on calvaria of Wistar rats, SCB gel preparations associated with bone morphogenetic protein (BMP) showed to be a suitable scaffold for the BMP, presumably facilitating the controlled release of BMP during bone repair 11 .…”

Section: Introductionmentioning

confidence: 99%

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The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation. METHODS:Thirty Wistar rats were submitted to a one 7-mm-diameter defect and divided equally into three experimental groups, with two different postoperative times of evaluation, 90 and 120 days. Each calvaria defect was filled up with clot (control group), particulated autogenous bone or granulated SCB. Five animals of each group were assessed at 90 and 120 days after surgery. In these two periods, histological and histometric analysis were obtained. RESULTS:The clot group showed a bone resorption trend while the autogenous bone group a bone repair trend. However in the SCB group, the critical defect filled up only with fibrous connective tissue and presented none bone neoformation. CONCLUSION:The sugarcane biopolymer when used in critical size defects was a biocompatible material and proved to be a good material to fill bone cavities, keeping them as uniform areas filled with soft tissue and avoiding the tissue shrinkage.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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“…The bacterial cellulose (BC) membrane, a biopolymer made from sugarcane molasses, has been developed at the Experimental Station of Sugar Cane in Carpina (EECC), Federal University of Pernambuco, Brazil (UFRPE) 10 . Several studies, Including experimental analyzes and clinical trials have shown that BC is non-toxic, biocompatible and effective for tissue remodeling [11][12][13][14] .…”

Section: Hronic Venous Disease (Cvd) Of the Lower Limbs (Ll) Ismentioning

confidence: 99%

Efficacy of bacterial cellulose membrane for the treatment of lower limbs chronic varicose ulcers: a randomized and controlled trial

Cavalcanti

Pinto

Oliveira

et al. 2017

Rev. Col. Bras. Cir.

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Objective: to evaluate the efficacy of Bacterial Cellulose (BC) membrane dressings in the treatment of lower limb venous ulcers. Methods: we carried out a prospective, randomized, controlled study of 25 patients with chronic venous ulcer disease in the lower limbs from the Angiology and Vascular Surgery Service of the Federal University of Pernambuco Hospital and from the Salgado Polyclinic of the County Health Department, Caruaru, Pernambuco. We randomly assigned patients to two groups: control group, receiving dressings with triglyceride oil (11 patients) and experimental group, treated with BC membrane (14 patients). We followed the patients for a period of 120 days. Results: There was a reduction in the wound area in both groups. There were no infections or reactions to the product in any of the groups. Patients in the BC group showed decreased pain and earlier discontinuation of analgesic use. Conclusion: BC membrane can be used as a dressing for the treatment of varicose ulcers of the lower limbs.

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“…This technique consists in using biological membrane to form a physical barrier, of bone defects and has demonstrated biocompatibility and low cytotoxicity in studies [9][10][11] that preceded this research.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel of polysaccharide of sugarcane molasses as carrier of bone morphogenetic protein in the reconstruction of critical bone defects in rats

Júnior¹,

Carvalho²,

Catunda³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To evaluate the benefit of using carriers such as the biopolymer gel (hidrogel of polysaccharide of sugarcane molasses) associated with the bone morphogenetic proteins (BMP's) in the repair of critical bone defects in calvaria of Wistar rats. METHODS:Forty-two rats were submitted to a surgical calvaria bone defects. These animals were divided into two experimental groups, positive control group and negative control group. The Group I the calvaria defect was filled up with biopolymer gel, biological membrane, BMP and lyophilized graft. The Group II was treated with biopolymer gel, BMP and lyophilized graft. And the group III (positive control group) was treated with BMP, lyophilized graft and biological membrane. In the negative control group (Group IV) a defect was made in the rat calvaria and the animals were sacrificed immediately after the surgery. The animals of experimental groups and positive control group were slaughtered after subsequent periods of 90 and 180 days. In these periods, the histological analysis and image assessment by cone bean tomographic imaging were obtained. RESULTS:There was highest bone tissue formation with statistically significant results in the groups that associated biopolymer gel and membrane (Group I), followed by the group III (BMP, lyophilized graft and biological membrane). The lower bone formation occurred in the group not using the sugarcane biopolymer gel (Group II). The radiolucent areas of the analyzes of 180 days among the groups studied were respectively, 14.98 mm², 26.65 mm² and 35.81 mm². CONCLUSION:The biopolymer gel showed to be an excellent bone morphogenetic protein carrier, probably by facilitating the controlled release of these proteins in the process of bone repair.

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A cellulosic exopolysaccharide produced from sugarcane molasses by a Zoogloea sp.

Cited by 69 publications

References 10 publications

The biopolymer sugarcane as filling material of critical defects in rats

The biopolymer sugarcane as filling material of critical defects in rats

Efficacy of bacterial cellulose membrane for the treatment of lower limbs chronic varicose ulcers: a randomized and controlled trial

Hydrogel of polysaccharide of sugarcane molasses as carrier of bone morphogenetic protein in the reconstruction of critical bone defects in rats

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