Efficacy of bacterial cellulose membrane for the treatment of lower limbs chronic varicose ulcers: a randomized and controlled trial

Cavalcanti, Luciana Marins; Pinto, Flávia Cristina Morone; Oliveira, Glícia Maria de; Lima, Salvador Vilar Correia; Aguiar, José Lamartine de Andrade; Lins, Esdras Marques

doi:10.1590/0100-69912017001011

Cited by 35 publications

(35 citation statements)

References 30 publications

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“…Beside the treatment of burn wounds, BNC was applied in chronic venous ulcers. There were no infectious complications in the treatment group and, furthermore, less pain and an earlier withdrawal of analgesic medications [120].…”

Section: In Vivo Scaffoldsmentioning

confidence: 80%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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Nanocelluloses are natural materials with at least one dimension in the nano-scale. They combine important cellulose properties with the features of nanomaterials and open new horizons for materials science and its applications. The field of nanocellulose materials is subdivided into three domains: biotechnologically produced bacterial nanocellulose hydrogels, mechanically delaminated cellulose nanofibers, and hydrolytically extracted cellulose nanocrystals. This review article describes today's state regarding the production, structural details, physicochemical properties, and innovative applications of these nanocelluloses. Promising technical applications including gels/foams, thickeners/stabilizers as well as reinforcing agents have been proposed and research from last five years indicates new potential for groundbreaking innovations in the areas of cosmetic products, wound dressings, drug carriers, medical implants, tissue engineering, food and composites. The current state of worldwide commercialization and the challenge of reducing nanocellulose production costs are also discussed.

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Section: In Vivo Scaffoldsmentioning

confidence: 80%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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“…One example was the study of Almeida and co‐workers that showed that BC used in the form of patches for 24 h did not promote skin irritation (Almeida et al ., ). Also, BC tested for the treatment of chronic varicose ulcers of lower limbs for 120 days showed a decrease in the depth of the ulcer suggesting that BC induced tissue remodelling without associated toxicity (Cavalcanti et al ., ).…”

Section: Biocompatibility Of Bacterial Cellulosementioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

359

231

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Summary Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical–chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC‐based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.

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“…In order to be defined as elderly, a person must have a chronological age ≥ 65 years in developed countries, or be from 50 to 64 years old and have clinical conditions or physical limitations affecting the ability to walk or to perform activities of daily living, because of their physical fitness or the physiological conditions affected. 14 Therefore, the study enrolled patients over the age of 50 who had chronic venous ulcers classified as CEAP 6 according to the international consensus on chronic venous diseases (open and active ulcers) 15 and who had been diagnosed with the condition by a physician. One patient who had not been diagnosed was enrolled on the study after consultation with a vascular surgeon who confirmed the condition.…”

Section: Methodsmentioning

confidence: 99%

Triagem da sarcopenia e fragilidade em pacientes com úlceras venosas crônicas: um estudo transversal

et al. 2020

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Resumo Contexto Pacientes com úlceras venosas reportam múltiplas comorbidades e são mais propensos a ser fisicamente inativos. A sarcopenia e a fragilidade aumentam a vulnerabilidade de um indivíduo para maior dependência e/ou morte. Objetivos Verificar presença da sarcopenia e fragilidade em pacientes portadores de úlceras venosas crônicas. Métodos Estudo observacional e transversal, realizado com 9 pacientes com idade média de 67,4 ± 8,42 anos e portadores de úlcera venosa nos membros inferiores classificadas no Consenso Internacional de Doenças Venosas Crônicas (CEAP) em estágio 6. Para identificação e classificação da sarcopenia, foi avaliada a força (dinamometria manual), a velocidade da marcha (teste de caminhada de 10 metros) e a massa muscular (circunferência da panturrilha). Para triagem de fragilidade, foram utilizados os critérios de Fried: perda de peso não intencional, fadiga, redução da força e da velocidade da caminhada e baixa atividade física. Resultados O fenótipo de fragilidade foi mais frequente (n = 9; 100%) em relação à sarcopenia (n = 1; 11,1%). Entre os critérios de Fried, os mais frequentes foram a exaustão (n = 9; 100%), seguida pela baixa atividade física (n = 8; 88,8%) e fraqueza muscular (n = 5; 55%). Por fim, o critério menos frequente foi a diminuição da velocidade da marcha (n = 2; 22,2%). No diagnóstico de sarcopenia, foi observada redução da força associada à redução da massa muscular (n = 1; 11,1%). Conclusões Pacientes com úlceras venosas crônicas apresentam condição de fragilidade ou pré-fragilidade, enquanto a condição de sarcopenia foi pouco frequente.

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Efficacy of bacterial cellulose membrane for the treatment of lower limbs chronic varicose ulcers: a randomized and controlled trial

Cited by 35 publications

References 30 publications

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Triagem da sarcopenia e fragilidade em pacientes com úlceras venosas crônicas: um estudo transversal

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