A “Cat”‐astrophic Case of <i>Bartonella henselae</i> infective endocarditis followed by cardiac transplantation salvage therapy

Kuan, William; Dulnuan, Kenneth; Guglin, Maya; Haddad, Hanine El; Kolodziej, Andrew; Leventhal, Andrew; Rajagopalan, Navin

doi:10.1111/tid.13179

Cited by 4 publications

(2 citation statements)

References 16 publications

(27 reference statements)

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“…Retreated with 2 weeks of Gentamicin plus Doxycycline and 4 weeks of Doxycycline Not reported [24] 66 yo female Yes Yes, bioprosthetic aortic valve Negative TEE, but fulfilled all five conditions for modified Duke minor criteria Crescentic glomerulonephritis, Right central retinal artery occlusion, leukopenia & thrombocytopenia Multiple sets negative B. henselae 1:1600 MultipleANA 1:320, Positive RF, c-ANCA positive Bartonella PCR testing on kidney biopsy tissue negative Not applicable 2 weeks of Gentamicin and 4 months of Doxycycline, until titer decreased to 1:400. Almost started on Rituximab, in addition to steroids prior to return of positive B. henselae titer [25] Male Yes Yes, bicuspid aortic valve with two separate aortic valve replacements Bioprosthetic aortic valve Acute renal failure, two aneurysmal hemorrhagic stroke, eventually heart failure Several negative B. henselae IgG 1:> /= 1024, IgM 1:20 None DNA PCR positive initially, negative subsequently. Valve tissue cultures negative.…”

Section: Discussionmentioning

confidence: 99%

A case of Bartonella henselae native valve endocarditis presenting with crescentic glomerulonephritis

Patel

Koran

Call

et al. 2022

IDCases

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Bartonella endocarditis is often an elusive diagnosis, usually derived from evaluating multiple laboratory tests and assessment of presenting symptoms. Herein we describe a case of Bartonella henselae native mitral valve endocarditis with an initial presentation of volume overload and renal failure. The Bartonella organism is tedious to isolate from culture medium, causing most diagnoses to be delayed. Due to the destructive nature of B. henselae endocarditis, the need for rapid identification remains prudent. This therefore creates an opportunity for Next Generation Sequencing (NGS) to be used. We further summarize the varied presentations that may be associated with B. henselae endocarditis, and hope that this will heighten the clinicians’ awareness of this entity when presented with acute onset renal failure and culture negative vegetations.

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Section: Discussionmentioning

confidence: 99%

A case of Bartonella henselae native valve endocarditis presenting with crescentic glomerulonephritis

Patel

Koran

Call

et al. 2022

IDCases

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“…Septic embolus from infectious endocarditis is a rarely reported cause of CRAO [1][2][3] and, similarly, Bartonella henselae represents a rarely reported cause of infectious endocarditis. 4 Herein, we report a patient who presented with acute painless vision loss from a CRAO secondary to B. henselae-related bacteremia and infectious endocarditis.…”

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confidence: 99%

Central Retinal Artery Occlusion as Presentation of Bartonella Endocarditis

Chebolu¹,

Wallsh²,

Falk³

et al. 2023

RETINAL Cases &Amp; Brief Reports

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Background/Purpose: To describe a rare ocular presentation of a systemic illness and the important lifesaving diagnosis made by a complete eye examination. Methods: The patient was evaluated with a comprehensive ophthalmic examination and followed closely in the outpatient setting with optical coherence tomography, fluorescein angiography, and color fundus photos. Results: A 66-year-old man presented with acute vision loss of the left eye. A complete eye examination revealed that he had a central retinal artery occlusion. Systemic workup revealed that he had a mitral valve vegetation and blood cultures grew Bartonella henselae. His kidney biopsy showed membranoproliferative glomerulonephritis, which is often seen with septic emboli. Furthermore, the patient lacked any ocular inflammatory signs. This constellation of findings was diagnostic for a thromboembolic etiology causing his central retinal artery occlusion. At follow-up, the optical coherence tomography demonstrated inner retinal hyperreflectivity and the fluorescein angiogram showed segmented flow and no neovascularization. On follow-up, the patient had a stable examination with light perception vision and completed antibiotic therapy for bartonella endocarditis. Conclusion: The detection of a fatal systemic illness was made promptly with a thorough ocular examination. We highlight the importance of a multidisciplinary approach in making a lifesaving diagnosis.

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Heart transplantation as salvage treatment of intractable infective endocarditis

Tattevin¹,

Muñóz²,

Moreno³

et al. 2023

Infectious Diseases

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Surgery was performed in 50% of patients with no significant difference in survival between those who were treated with combined medical/surgical treatment and those treated with medical therapy alone. Overall survival at 1, 4, and 10 years was 93%, 83%, and 66%, respectively.Conclusion. IE due to NVS is a rare entity and is associated with a high rate of serious complications and may involve multiple valves. Long-term, two-thirds of the patients survived more than 10 years.Disclosures.

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A “Cat”‐astrophic Case of Bartonella henselae infective endocarditis followed by cardiac transplantation salvage therapy

Cited by 4 publications

References 16 publications

A case of Bartonella henselae native valve endocarditis presenting with crescentic glomerulonephritis

A case of Bartonella henselae native valve endocarditis presenting with crescentic glomerulonephritis

Central Retinal Artery Occlusion as Presentation of Bartonella Endocarditis

Heart transplantation as salvage treatment of intractable infective endocarditis

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