A Case Study

Pegels, J. G.; Bruynes, E.C.E.; Hr, Korthals Altes; Cp, Engelfriet; Borne, von dem

doi:10.1111/j.1423-0410.1982.tb01097.x

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…Additionally, he showed a markedly prolonged survival of an experimental skin graft from an HLA-incompatible donor. It was argued that the HNA-5a alloantibody might have blocked leukocyte interactions in the graft [100,102]. The first case of NIN caused by an HNA-5a alloantibody was described in 2011 [103].…”

Section: Hna-5mentioning

confidence: 99%

Molecular Genetics of the Human Neutrophil Antigens

Flesch

Reil²

2018

Transfus Med Hemother

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Background and Objective: Antibodies to human neutrophil antigens (HNAs) have been implicated in transfusion-related acute lung injury and allo- and autoimmune neutropenia. To date, five HNA systems are assigned, and during the last decades enormous efforts have been undertaken to identify the underlying genes and to characterize the antigens. This review of the literature will provide the current genetic, molecular and functional information on HNAs. Recent Findings: New information on alleles and antigens has been added to nearly each of the five HNA systems. HNA-1d has been added as the antithetical epitope to HNA-1c that is located on the glycoprotein encoded by FCGR3B*02 but not by FCGR3B. FCGR3B*04 and *05 now are included as new alleles. A CD177*787A>T substitution was demonstrated as the main reason for the HNA-2-negative phenotype on neutrophils. The target glycoprotein of HNA-3 antibodies could be identified as choline transporter-like protein 2 (CTL2) encoded by SLC44A2. The conformation sensitive epitope discriminates between arginine and glutamine at position 152 resulting in HNA-3a and HNA-3b. An additional Leu151Phe substitution can impair HNA-3a antibody binding. Recently an alloantibody against HNA-4b which discriminates from HNA-4a by an Arg61His exchange of the glycoprotein encoded by the ITGAM gene was reported in neonatal alloimmune neutropenia. An update of the current HNA nomenclature based on the new findings was provided in 2016 by the ISBT Granulocyte Immunobiology Working Party nomenclature subcommittee. Conclusions: The molecular basis of each of the five HNA antigen systems has been decoded during the past decades. This enables reliable molecular typing strategies, antibody detection and specification as well as development of new assays based on recombinant antigens. However, research on HNA alleles, antigens, and antibodies is not finally terminated and also in the future will add new findings.

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Section: Hna-5mentioning

confidence: 99%

Molecular Genetics of the Human Neutrophil Antigens

Flesch

Reil²

2018

Transfus Med Hemother

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“…[ 11 ] In addition, a multitransfused patient with aplastic anemia who produced only anti-HNA-5a had prolonged survival of a skin graft from human leukocyte antigen (HLA) unidentical donor, because the leukocyte interactions in the graft had been blocked. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

Frequencies of human neutrophil antigen-4 and human neutrophil antigen-5 among Thai blood donors

Khantisitthiporn

Kaset

Intharanut

et al. 2015

Asian J Transfus Sci

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Context:Antibodies against human neutrophil antigens (HNAs) are implicated in immune-mediated neutropenia, transfusion-related acute lung injury and febrile transfusion reactions.Aims:This study aimed to determine HNA gene frequencies of the HNA-4 and HNA-5 systems among Thai populations and compare these frequencies with those previously reported for other populations.Materials and Methods:800 DNA samples obtained from 500 unrelated healthy blood donors from Bangkok and 300 samples from Chiang Mai, Thailand were included. Samples were typed for each HNA allele including HNA-4a, HNA-4b, HNA-5a, and HNA-5b using an in-house polymerase chain reaction with sequence-specific primer technique.Results:The frequencies of HNA-4a and HNA-4b alleles in central Thais were 0.975 and 0.025, respectively and for Northern Thais, their frequencies were 0.965 and 0.035, respectively. For HNA-5a and HNA-5b alleles, their frequencies were 0.771 and 0.229; 0.748, and 0.252 in central and Northern Thais, respectively. The frequencies of HNA-4 and HNA-5 systems in central Thais are closely related to those in Northern Thais (P > 0.05). However, their frequencies were different from other populations (P < 0.001), except HNA-5a and HNA-5b gene frequencies in Thais were similar to Caucasians (P > 0.05).Conclusion:This study could contribute to predict the risk of alloimmunization to HNA-4 and HNA-5 systems, especially in feto-maternal incompatibility in Thais.

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Advances in the treatment of thrombocytopenia

Veenhoven¹,

Borne²

1985

Supportive Therapy in Haematology

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A Case Study

Cited by 9 publications

References 9 publications

Molecular Genetics of the Human Neutrophil Antigens

Molecular Genetics of the Human Neutrophil Antigens

Frequencies of human neutrophil antigen-4 and human neutrophil antigen-5 among Thai blood donors

Advances in the treatment of thrombocytopenia

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