“…Pregabalin, also known as 3-isobutyl-γ-aminobutyric acid, is a racemate-forming chiral compound with anticonvulsant and anxiolytic effects. , This top-selling drug was developed and commercialized by Pfizer, but since 2019, it has been available worldwide as a generic medication. , Pregabalin has a wide indication range, including the treatment of epilepsy, generalized anxiety disorder, neuropathic pain, and other pain-related problems. The desired pharmacological activity is carried by the ( S )-enantiomer; thus, it is produced in enantiopure form. , Besides enantioselective synthesis using the chiral pool, asymmetric catalysis, − chemoenzymatic reaction, − or chiral auxiliaries, , several chiral resolution methods were developed.…”