A case study of measles vaccination for university students during the measles outbreak in Tokyo, Japan, 2007

Fujisaki, Ryuichi; Yamamura, Masato; Abe, Shigeru; Shimogawara, Kousuke; Kasahara, Michihiro; Nishiya, Hajime; Makimura, Mizue; Makimura, Koichi

doi:10.1007/s10156-011-0343-x

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…In contrast, Fujisaki et al reported that in the same class of university setting, 42% of students presented with secondary measles transmission from the index case. 4 This difference in prevalence of secondary transmission to that found in our study may be due to variations in the standard precautions taken among the two groups.…”

Section: Discussioncontrasting

confidence: 67%

Estimation of secondary measles transmission from a healthcare worker in a hospital setting

Tajima

Nishimura

Hongō

et al. 2014

International Journal of Infectious Diseases

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Measles among healthcare workers (HCWs) is associated with a significant risk of nosocomial transmission to susceptible patients. When a measles case occurs in the healthcare setting, most guidelines recommend exhaustive measures. To evaluate the effects of measures against measles transmission in the healthcare setting precisely, it is essential to determine whether secondary transmission generally occurs. This study describes, for the first time, the actual secondary transmission rate for a measles-infected HCW in a ward with no special air ventilation capacity. The routine treatment of a number of immunocompromised patients occurs in this ward, and thus patients as well as HCWs have a thorough understanding and practice of standard and extended precautions. Our paired serum sample study revealed that none of the people in the ward exposed to the HCW at the catarrhal stage over a period of 4 days exhibited elevated levels of antibodies against measles. We suggest that strict adherence to standard and expanded precautions among patients and HCWs may be effective for preventing the transmission of a highly airborne disease, such as measles.

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Section: Discussioncontrasting

confidence: 67%

Estimation of secondary measles transmission from a healthcare worker in a hospital setting

Tajima

Nishimura

Hongō

et al. 2014

International Journal of Infectious Diseases

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“…4 Despite this campaign, measles outbreaks have continued to occur in Japan. [4][5][6][7] A considerable number of paediatric varicella cases are also reported annually in Japan; numbers of 200000-300000 per year have been reported from $3000 paediatric facilities. 8 Vaccination against varicella is optional in Japan for children >1 year of age and documented vaccination rates are only 21.3%.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of a complement fixation assay and enzyme immunoassay to determine the seroprevalence of measles and varicella in a survey of healthcare workers

et al. 2013

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“…In Japan, a second dose MV vaccination was only introduced routinely for preschool year children in 2006 [Center for Disease Control Prevention, 2008]. This intensification of measles control resulted in a substantial reduction in the incidence of this disease [Yoshikura, ], after epidemics had occurred in many regions between 2007 and 2008 [Nagai et al, ; Fujisaki et al, ]. In 2007, we studied a measles epidemic at a junior high school, which started from an unvaccinated student who continued to attend school after fever developed.…”

Section: Introductionmentioning

confidence: 99%

Environmental tobacco exposure is associated with vaccine modified measles in junior high school students

Suzuki

Sato

Watanabe

et al. 2015

Journal of Medical Virology

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Vaccine modified measles (VMM) affects individuals with attenuated vaccine induced immunity. An outbreak of measles occurred in a junior high school, starting from an unvaccinated eighth-grade student who developed natural measles and affected a majority of students who were immunized with a low potent strain of measles vaccine (TD97). To determine whether environmental tobacco smoke (ETS) exposure was associated with the development of VMM in this population, a questionnaire was used asking whether students had VMM symptoms during the outbreak and the smoking status of family members. VMM was defined in the study population as occurrence of fever and/or erythema, along with documented history of measles vaccination. A total of 513 students (85.9%) responded. Overall, the presence of in-house smokers did not differ between VMM students (49.3%) and non-VMM students (50.2%). However, in the ninth grade, presence of an in-house smoker was significantly higher in the family of VMM students (54.0%) than in non-VMM students (36.6%) (P = 0.044). Urinary cotinine levels were also measured in selected students (n = 37). Among families with at least one smoker, urinary cotinine levels were significantly higher in VMM students than in non-VMM students (P = 0.032). Furthermore, a multivariable logistic regression analysis showed that a high urinary cotinine level (>10 ng/mg creatinine; 13.5 percentile) was associated with the development of VMM. Our findings suggest that a high level of ETS exposure may be associated with an increased risk of VMM in a population with attenuated vaccine induced immunity against measles.

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A case study of measles vaccination for university students during the measles outbreak in Tokyo, Japan, 2007

Cited by 3 publications

References 19 publications

Estimation of secondary measles transmission from a healthcare worker in a hospital setting

Estimation of secondary measles transmission from a healthcare worker in a hospital setting

Comparative analysis of a complement fixation assay and enzyme immunoassay to determine the seroprevalence of measles and varicella in a survey of healthcare workers

Environmental tobacco exposure is associated with vaccine modified measles in junior high school students

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