A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy

Siegel, Karen Lohmann; Kepple, Thomas M.; Stanhope, Steven J.

doi:10.1016/j.clinbiomech.2006.11.002

Cited by 15 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that depending on the severity of muscle and brain dysfunction, there are at least 4 subtypes of DMD: (A) early infantile DMD; (B) classical DMD; (C) moderate pure motor DMD; (D) severe pure motor DMD [2,3]. Various approaches have been used to study the relationship between gait and muscle strength in myopathies [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…A few studies in the literature describe a substantial quantity of instruments used in order to assess pediatric neuromuscular diseases, focusing on functional aspects [6,[8][9][10], physical performance [4,11,12] and muscular strength [13][14][15]. In a review, Bushby et al recommended strength testing of the lower extremity by manual muscle testing every 6 months, the timed 10 meter walk test (10 MWT) and the Vignos lower extremity scale for DMD management [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of Loss of Gait in Duchenne Muscular Dystrophy Using the Ten Meter Walking Test Rates

Pizzato¹,

Baptista²

2016

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

Objective: To evaluate the performance of boys with DMD in the ten meter walking test (10 MWT) in order to predict gait loss. Method: This longitudinal study consisted of consecutive evaluations, minimum of 3 and maximum of 12, conducted every 4 months, during 33 months, depending on time of inclusion in the study. Ambulant boys with DMD (n=18), ages 4 to 13 years, mean 7 (SD=2.22), were assigned to Ambulatory group (A; n=11) or Non-Ambulatory group (NA; n=7) according to their status at the end of the study. Diagnosis was based on the absence of dystrophin in a muscle biopsy and/or identification of a mutation of the dystrophin-gene. The main outcome measures were: 10 MWT total time and rates between two consecutive sessions. Secondary measures included: functional status and muscle strength of the hip, knee and ankle. Results: The 10 MWT total time for the NA group oscillated over time, while remaining steady for the A group. The NA group showed mean of 16.18 s (CI 95% 14.38-17.98) and the A group showed mean of 10.2 s (CI 95% 9.08-11.24). The difference between groups was estimated as-5.98 s (CI 95%-8.11;-3.89). The linear model of mixed effects identified significant increase in 10 MWT time for the NA group and decrease for the A group. The rates were >1.25 for participants who became wheelchair users, indicating increased time to perform 10 MWT overtime. Conclusion: Rates ≥ 1.25 indicate the borderline between independent gait and wheelchair confinement and are useful for predicting gait loss.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediction of Loss of Gait in Duchenne Muscular Dystrophy Using the Ten Meter Walking Test Rates

Pizzato¹,

Baptista²

2016

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

show abstract

“…Kinematic and kinetic data were calculated. The biomechanical model was described and validated by Kepple et al [16] and has been used previously to assess energy flow through the lower extremity body segments in individuals without disability [17] and joint moment contributions to knee and hip joint accelerations in individuals with pathology [10,18,19]. The model had seven segments: a combined head, arms and trunk segment, and bilateral thighs, shanks and feet.…”

Section: Induced Acceleration Analysismentioning

confidence: 99%

Joint moment contributions to swing knee extension acceleration during gait in individuals with spastic diplegic cerebral palsy

2011

View full text Add to dashboard Cite

“…A number of clinical IIM subtypes are recognised, including dermatomyositis (DM), juvenile DM (JDM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), anti-synthetase syndrome (ASS), and sporadic inclusion body myositis. A wide variety of IIM manifestations can occur, including muscle inflammation (myositis) of proximal limb muscles leading to weakness [3][4][5][6], skin inflammation, interstitial lung disease and an increased malignancy risk. The disease course is variable, with many patients reporting unpredictable episodic exacerbations of symptoms and disability [7].…”

Section: Introductionmentioning

confidence: 99%

Patient insights on living with idiopathic inflammatory myopathy and the limitations of disease activity measurement methods – a qualitative study

et al. 2020

View full text Add to dashboard Cite

Background The idiopathic inflammatory myopathies (IIMs) are chronic autoimmune conditions, typically resulting in proximal muscle weakness and impacting upon quality of life. Accurate measurement of IIM disease activity is imperative for appropriate medical management and carrying out valid clinical trials. The International Myositis Assessment and Clinical Studies Group (IMACS) “Disease Activity Core Set Measures” are the current gold-standard of IIM disease activity assessment. Anecdotally, patients with an IIM report that the IMACS Core Set Measures and other available methods do not necessarily capture their perceived disease activity. Investigating the patient experiences of living with an IIM and their views on the accuracy of the IMACS Core Set Measures will provide valuable insights for both clinical and research purposes. Methods Eighteen interviews with patients with an IIM were carried out and analysed thematically, using a grounded theory approach. Experiences on living with an IIM and perceptions on the accuracy of disease activity measurement methods were explored. Results Interview analysis revealed four themes: 1) fatigue, 2) pain, 3) day-to-day symptom variation, 4) limitations of creatine kinase levels and manual muscle testing. Conclusions This study has provided valuable insights into patient experiences of living with an IIM. Aspects of IIM disease activity perceived not to be wholly measured by the IMACS Core Set Measures have also been identified. These findings have implications for future IIM clinical care and research, in particular providing justification for research into pain, fatigue and symptom variation.

show abstract

A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy

Abstract: Background-The purpose of this case series was to quantify different strategies used to compensate in gait for hip muscle weakness.

Cited by 15 publications

References 25 publications

Prediction of Loss of Gait in Duchenne Muscular Dystrophy Using the Ten Meter Walking Test Rates

Prediction of Loss of Gait in Duchenne Muscular Dystrophy Using the Ten Meter Walking Test Rates

Joint moment contributions to swing knee extension acceleration during gait in individuals with spastic diplegic cerebral palsy

Patient insights on living with idiopathic inflammatory myopathy and the limitations of disease activity measurement methods – a qualitative study

Contact Info

Product

Resources

About