A Case Study: Comprehensive Approach for Treating Horizontal Neck Wrinkles Using Hyaluronic Acid Injections and Thread-Lifting

Abstract

Background Horizontal neck wrinkles develop during the aging process. Aims This study assessed the effectiveness of a comprehensive approach to treating horizontal neck wrinkles using non-cross-linked hyaluronic acid injection and smooth absorbable PPDO (Poly p-dioxanon) thread insertion. Methods Ten patients with horizontal neck wrinkles were treated with hyaluronic acid injection and thread-lifting. The clinical outcomes were evaluated six months after treatment. Results The median global aesthetic improvement scale scores evaluated by plastic surgeons and the patients were 4.3 ± 0.8 (3–5) and 4.1 ± 0.7 (3–5), respectively, at six months post-treatment. Five (50%) patients strongly agreed, and three subjects (30%) agreed that their horizontal neck wrinkles had improved following treatment. No serious adverse events, including infections, lumps, irregularities, or the Tyndall effect, occurred during treatment. Conclusion This study revealed that a comprehensive approach using hyaluronic acid and thread-lifting provided satisfactory and effective clinical outcomes in treating horizontal neck wrinkles. Level of evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.

Infraorbital Rejuvenation Combined with Thread-Lifting and Non-cross-linked Hyaluronic Acid Injection: A Retrospective, Case-Series Study

“…Non-cross-linked HA, when compared to cross-linked HA, reduces the risk of lump formation, irregularities, and vascular complications, especially in the thin periorbital skin. Previous studies, including Wang [ 13 ] and our own [ 12 ], have demonstrated the short-term efficacy and safety of non-cross-linked HA for treating mild-to-severe horizontal neck wrinkles. Additionally, due to the rapid metabolism of non-cross-linked hyaluronic acid, we conducted four treatments to sustain its therapeutic effect on the skin.…”

“…Previous studies have shown that threads inserted into the subcutaneous tissue layer lead to immediate volume enhancement due to thread volume and induced swelling. Smooth-surfaced PPDO threads are particularly suitable for filling depressions and restoring soft tissue volume [ 12 ].…”

“…Previous studies have indicated that the insertion of PDO (polydioxanone) threads can be a valuable, supplementary, and non-invasive technique for infraorbital rejuvenation [ 11 ]. Our study introduced a comprehensive approach involving the use of non-cross-linked hyaluronic acid and PPDO (Poly- p -dioxanone) thread inserts, which yielded satisfactory and effective clinical outcomes in treating horizontal neck wrinkles [ 12 ]. So, the aim of this study is to outline a novel approach for infraorbital rejuvenation, employing non-cross-linked hyaluronic acid injection and PPDO (poly-p-dioxanone) thread insert.…”

Histopathologic analysis of hyaluronic acid composite solution following intravascular injection: Variability and safety

“…Non-crosslinked hyaluronic acid composite solution, which is commonly injected into superficial soft tissue for cosmetic enhancement, has been widely used in mesotherapy and to treat horizontal neck wrinkles. [1][2][3][4] It differs from crosslinked hyaluronic acid in terms of biological properties and is considered relatively safe as it is not believed to obstruct the vessel or form emboli, 5 with no serious complications reported. However, mechanical embolism is not the only potential risk associated with fillers 6 ; an embolus may comprise blood cell components including red thrombi that can enter the gaps in the hyaluronic acid gel structure, evolving into white and mixed thrombi over time.…”

“…Non‐crosslinked hyaluronic acid composite solution, which is commonly injected into superficial soft tissue for cosmetic enhancement, has been widely used in mesotherapy and to treat horizontal neck wrinkles 1–4 . It differs from crosslinked hyaluronic acid in terms of biological properties and is considered relatively safe as it is not believed to obstruct the vessel or form emboli, 5 with no serious complications reported.…”