A case series of rapidly growing mycobacterial catheter-related bloodstream infections among immunocompetent patients

Mizusawa, Masako; Vindenes, Tine; Buckley, Sarah; Armstrong, Catharina

doi:10.1016/j.jctube.2020.100196

Cited by 3 publications

(8 citation statements)

References 14 publications

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“…Finally, while most of the patients had CRBSI, the rates were overall lower than previous reports. For example, CRBSI was reported in 85%-100% in four earlier studies while the rate was 50% in this study [23] , [24] , [28] , [29] . This could be related to overall differences between baseline characteristics of this cohort, higher proportion of MABC BSI cases, and presence of strict predefined criteria for CRBSI in current study [28] , [29] , [33] .…”

Section: Discussioncontrasting

confidence: 51%

“…RGM BSI has been described in mostly immunosuppressed patients, frequently secondary to malignancies and their entailed therapies [23] , [24] , [25] , [26] . Mizusawa et al showed in a small cohort of 17 immunocompetent patients that 94% of patients were persons who inject drugs (PWID), highlighting the role of skin barrier breakdown in this patient population.…”

Section: Discussionmentioning

confidence: 99%

“…Mizusawa et al showed in a small cohort of 17 immunocompetent patients that 94% of patients were persons who inject drugs (PWID), highlighting the role of skin barrier breakdown in this patient population. Additionally, 100% of those patients had peripherally inserted central catheter line and were receiving intravenous (IV) antibiotics for another primary infection prior to being diagnosed with RGM BSI [23] . Other comorbidities listed in those previous studies match those seen in our cohort including gastrointestinal pathology, diabetes mellitus, ESRD, and autoimmune disease [27] , [28] , [29] , [30] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 99%

“…For example, 17.9% of our patients had active hematological malignancy, and while this still falls within the previously reported range it is lower than some prior studies [29] . Additionally, our series consists of patients with solid organ transplant which is not shared across other cohorts [23] , [24] , [25] , [26] , [27] . Furthermore, some of those previous reports had individuals with solid organ cancer who developed RGM BSI that may confer a risk factor.…”

Section: Discussionmentioning

confidence: 99%

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Bloodstream infections with rapidly growing nontuberculous mycobacteria

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Tabaja

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et al. 2021

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bloodstream infections with rapidly growing nontuberculous mycobacteria

Comba

Tabaja

Almeida

et al. 2021

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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“…A multi-center case-control study [14] have showed that after PICC catheterization for more than 2 weeks, the risk of CRBSI continues to increase with the extension of PICC stay. The defense function of newborns with a birth weight of ≤ 1500 g is imperfect, and newborns with Apgar score ≤ 7 are in poor physical condition, which will increase the risk of CRBSI [15,16]. In response to the above risk factors, nurses should take appropriate measures as much as possible to reduce the occurrence of CRBSI, such as daily assessment of extubation indications, appropriate PICC care.…”

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors of PICC-related bloodstream infection in newborns: implications for nursing care

Ling

et al. 2021

Eur J Med Res

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Background It is necessary to analyze the characteristics and risk factors of catheter-related bloodstream infection (CRBSI) in newborns with peripherally inserted central catheter (PICC). Methods Newborns undergoing PICC catheterization in the neonatal department of our hospital from January 1, 2020 to January 31, 2021 were included. The characteristics of newborns with and without CRBSI newborns were compared and analyzed. Logistic regression analyses were performed to evaluate the risk factors of CRBSI in newborns with PICC. Results Three hundred eighty-six newborns with PICC were included, of whom 41 newborns had the CRBSI, the incidence of CRBSI in newborns with PICC was 10.62%. There were significant differences regarding the birth weight, durations of PICC stay, 5-min Apgar score, site of PICC insertion of PICC between CRBSI and no CRBSI group (all P < 0.05), and there were no significant differences regarding the gender, gestational age, cesarean section, mechanical ventilation and length of hospital stay between CRBSI and no CRBSI group (all P > 0.05). Escherichia coli (26.08%) and Staphylococcus aureus (23.92%) were the most common CRBSI pathogens in newborns with PICC. Logistic regression analysis indicated that birth weight ≤ 1500 g (OR 1.923, 95% CI 1.135–2.629), durations of PICC stay ≥ 21 days (OR 2.077, 95% CI 1.024–3.431), 5-min Apgar score ≤ 7 (OR 2.198, 95% CI 1.135–3.414) and femoral vein insertion of PICC (OR 3.044, 95% CI 1.989–4.306) were the independent risk factors of CRBSI in neonates with PICC (all P < 0.05). Conclusion For newborns with low birth weight, longer durations of PICC stay and femoral vein PICC insertion, they may have higher risks of CRBSI, and medical staff should take targeted measures to reduce the development of CRBSI.

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Disseminated non-tuberculous mycobacterial infection caused by Mycobacterium obuense in an immunocompromised patient: a case report

et al. 2023

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Background Mycobacterium obuense (M. obuense) is a rapidly growing mycobacterium (RGM) which has been considered nonpathogenic. Here, we report a case of disseminated non-tuberculous mycobacterial (NTM) infection caused by M. obuense in an immunocompromised patient. Case presentation A 16-year-old boy was referred to our hospital due to acute myeloid leukemia. During the treatment of leukemia, the patient exhibited continuous fever, and diffuse miliary nodules with random distribution were found on chest computed tomography. Repeated examinations of bacterial culture tests revealed sputum and urine samples to be smear-positive for acid-fast bacillus, and blood culture from a peripherally inserted central catheter line showed the growth of NTM. The NTM species was identified as M. obuense by mass spectrometry and confirmed by genome sequencing. Combination therapy with amikacin, rifampicin, azithromycin, and moxifloxacin significantly improved the patient’s symptoms and radiological findings. Conclusion We report a case of disseminated NTM infection caused by M. obuense for which combination anti-microbial therapy was effective. An immunocompromised host indwelling catheter is at risk of RGM bloodstream infections. Although relatively rare, M. obuense may be considered as a potential pathogen causing infectious diseases, especially in high-risk patients.

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A case series of rapidly growing mycobacterial catheter-related bloodstream infections among immunocompetent patients

Cited by 3 publications

References 14 publications

Bloodstream infections with rapidly growing nontuberculous mycobacteria

Bloodstream infections with rapidly growing nontuberculous mycobacteria

Analysis of risk factors of PICC-related bloodstream infection in newborns: implications for nursing care

Disseminated non-tuberculous mycobacterial infection caused by Mycobacterium obuense in an immunocompromised patient: a case report

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