A case series of Merkel cell carcinoma of the eyelid: a rare entity often misdiagnosed

Iuliano, Adriana; Tranfa, Fausto; Clemente, Lidia; Fossataro, Federica; Strianese, Diego

doi:10.1080/01676830.2018.1537291

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Higher loads of MCPyV have been observed in normal skin of patients with MCC than in matched controls, suggesting the hypothesis that higher viral loads predispose to disease 31 . MCC affects the eyelids in approximately 2.5% of cases 32 , and typically affects patients in their 6th decade or older 33 . This tumor has a poor prognosis with approximately 40% mortality.…”

Section: Discussionmentioning

confidence: 99%

Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva

Siegal

Gutowski

Akileswaran

et al. 2021

Sci Rep

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The human ocular surface hosts a paucibacterial resident microbiome and virome. The factors contributing to homeostasis of this mucosal community are presently unknown. To determine the impact of ocular enucleation and prosthesis placement on the ocular surface microbiome, we sampled conjunctival swabs from 20 anophthalmic and 20 fellow-eye intact conjunctiva. DNA was extracted and subjected to quantitative 16S rDNA PCR, biome representational karyotyping (BRiSK), and quantitative PCR (qPCR) confirmation of specific organisms. 16S ribosomal qPCR revealed equivalent bacterial loads between conditions. Biome representational in silico karyotyping (BRiSK) demonstrated comparable bacterial fauna between anophthalmic and intact conjunctiva. Both torque teno virus and Merkel cell polyoma virus (MCPyV) were detected frequently in healthy and anophthalmic conjunctiva. By qPCR, MCPyV was detected in 19/20 anophthalmic samples compared with 5/20 fellow eyes. MCPyV copy number averaged 891 copies/ng in anophthalmic conjunctiva compared with 193 copies/ng in fellow eyes (p < 0.001). These results suggest that enucleation and prosthesis placement affect the ocular surface flora, particularly for the resident virome. As MCPyV has been shown to be the etiologic cause of Merkel cell carcinoma, understanding the mechanisms by which the ocular surface regulates this virus may have clinical importance.

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Section: Discussionmentioning

confidence: 99%

Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva

Siegal

Gutowski

Akileswaran

et al. 2021

Sci Rep

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“…1 ), although plaque-like variants can also occur 7 . It affects the head and neck region in just 46 – 48% of all cases where the eyelid, with an incidence of 2.5 – 10%, is the most commonly affected anatomical structure of the head and neck region 8 . Interestingly, MCC of the eyelid affects twice as many women as men 9 .…”

Section: Introductionmentioning

confidence: 99%

“…1), allerdings kommen auch plaqueartige Varianten vor [7]. Die Kopf-Hals-Region ist in knapp 46-48 % aller Fälle betroffen, wobei das Augenlid mit einer Inzidenz von 2,5-10 % die am häufigsten betroffene anatomische Struktur der Kopf-Hals-Region darstellt [8]. Interessanterweise sind Frauen beim MCC des Augenlids doppelt so häufig betroffen wie Männer [9].…”

Section: Introductionunclassified

Das periokuläre Merkel-Zell-Karzinom – eine Übersicht klinischer Aspekte und aktueller Therapieoptionen

Esser

Grünewald

Mihailovic

2022

Klin Monbl Augenheilkd

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ZusammenfassungDas Merkel-Zell-Karzinom (MCC) stellt einen seltenen, jedoch hochaggressiven und rasch expandierenden malignen Hauttumor dar. Die periokuläre Region ist in etwa 10% der Fälle betroffen. Die aktuelle Therapieempfehlung des resektablen, nicht metastasierten MCC umfasst die chirurgische Totalexzision, allerdings sind bei Diagnosestellung bereits häufig Lymphknoten- oder Fernmetastasen vorhanden. Seit der Erstzulassung einer Immun-Checkpoint-Inhibitor-Therapie mit Avelumab für das metastasierte MCC im Jahr 2016 hat sich das mittlere Überleben im Vergleich zur zytostatischen Therapie erheblich gebessert bei gleichzeitig seltenerem Auftreten schwerwiegender therapieassoziierter unerwünschter Ereignisse. Weitere Immun-Checkpoint-Inhibitoren mit ersten vielversprechenden Ergebnissen sind derzeit noch in der klinischen Erprobung. Eine interdisziplinäre Betreuung an einem spezialisierten Zentrum mit Vorstellung in einem Tumorboard ist bei Patienten MCC aufgrund der komplexen Diagnostik, Therapie und Prognoseabschätzung essenziell.

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