A case report of primary pulmonary artery intimal sarcoma

Hieu, Nguyen Lan; Tu, Vu Ngoc; Hoan, Le; Hai, Hoang Bui; Luu, Doan Tien; Cương, Nguyễn Ngọc; My, Thieu Thi Tra; Minh, Tran Ngoc; Manh, Pham Thuan

doi:10.1016/j.radcr.2022.03.052

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Primary pulmonary artery chondrosarcoma is even rarer. In 1977, Hohbach and Mall reported the first case of primary pulmonary artery chondrosarcoma ( 5 ), and subsequently, sporadic cases have been reported in literature ( 6 - 8 ). In the current case, pathological examination of transcatheter aspirates at the referring hospital revealed the presence of a “chondrogenic component”, and routine pathological and immunohistochemical examinations of the surgically resected specimen during the index admission confirmed the diagnosis of a primary well-differentiated chondrosarcoma of the pulmonary artery.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary artery chondrosarcoma: case report

Zhang¹,

Xu²

2023

Transl Cancer Res

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Background Primary pulmonary artery sarcoma (PAS) is a rare tumor that presents like pulmonary embolism (PE), primary chondrosarcoma in the pulmonary artery is even rarer and few studies have been reported. PAS are commonly misinterpreted as in a clinical setting, many patients initially receive anticoagulant and thrombolysis therapy, but failed to respond. Management of this condition is difficult and prognosis is poor. We report a case of primary pulmonary artery chondrosarcoma that was initially misdiagnosed as PE and Inappropriate interventional therapy was performed, but with poor response. Finally, patient received surgical treatment, postoperative pathology confirmed primary pulmonary artery chondrosarcoma. Case Description A 67-year-old woman who had presented with cough, chest pain and shortness of breath for more than 3 months. Computed tomography pulmonary angiography (CTPA) showed filling defects were seen in the right and left pulmonary arteries, spreading to the outer lumen. The patient was initially diagnosed with PE and underwent transcatheter aspiration for pulmonary artery thrombus, transcatheter thrombolysis, and inferior vena cava filter placement at a local hospital, but with poor response. She was then referred for pulmonary artery tumor resection, endarterectomy and pulmonary arterioplasty. Histopathological examinations confirmed a diagnosis of primary PAS (chondrosarcoma). The patient developed in situ recurrence of pulmonary artery tumors in 10 months after surgery and received six cycles of adjuvant chemotherapy. The lesions progressed slowly after chemotherapy. The patient subsequently developed lung metastasis in 22 months and died of heart failure and respiratory failure 2 years after surgery. Conclusions PAS is an extremely rare and the clinical symptoms and radiological features often mimics PE, therefore When doctors make differential diagnosis of pulmonary artery mass lesions, especially when the anticoagulation and thrombolytic effects are very poor. They need to be alert to the possibility of PAS so that early diagnosis and early treatment can prolong the survival of patients.

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Section: Discussionmentioning

confidence: 99%

Primary pulmonary artery chondrosarcoma: case report

Zhang¹,

Xu²

2023

Transl Cancer Res

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“…the average age at onset of PAIs is 50 years and the age range of onset is estimated to be 13-86 years (5)(6)(7). there are no significant differences between male and female subjects in terms of the prevalence and outcomes of this condition based on previous evaluations (8). the clinical symptoms, laboratory findings and imaging features of PAIS are non-specific, which makes diagnosis difficult.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary thromboembolic disease or pulmonary artery intimal sarcoma: Case report and literature review

Shao

Deng

2022

Oncol Lett

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the present case study reported on a patient initially diagnosed with pulmonary embolism at the First Affiliated Hospital of Fujian Medical University (Fuzhou, china) in May 2021. Furthermore, a relevant literature review was performed. the patient was a 57-year-old chinese male who presented with dyspnea and wheezing following exercise. Physical examination revealed pulmonary valve second heart sound > aortic valve second heart sound but lack of swelling on both lower limbs, while the imaging results suggested pulmonary artery filling defects. Initially, the patient was diagnosed with pulmonary embolism and was administered anticoagulation treatment, which lasted for 3 months but proved to be ineffective. subsequent re-examination via chest computed tomography further indicated multiple nodules in the left hilum and lung. therefore, the patient was hospitalized for lung aspiration biopsy, which led to the final diagnosis of pulmonary artery intimal sarcoma based on the pathological review.

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A case report of primary pulmonary artery intimal sarcoma

Cited by 2 publications

References 15 publications

Primary pulmonary artery chondrosarcoma: case report

Primary pulmonary artery chondrosarcoma: case report

Pulmonary thromboembolic disease or pulmonary artery intimal sarcoma: Case report and literature review

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