Pulmonary thromboembolic disease or pulmonary artery intimal sarcoma: Case report and literature review

Abstract

the present case study reported on a patient initially diagnosed with pulmonary embolism at the First Affiliated Hospital of Fujian Medical University (Fuzhou, china) in May 2021. Furthermore, a relevant literature review was performed. the patient was a 57-year-old chinese male who presented with dyspnea and wheezing following exercise. Physical examination revealed pulmonary valve second heart sound > aortic valve second heart sound but lack of swelling on both lower limbs, while the imaging results suggested pulmonary artery filling defects. Initially, the patient was diagnosed with pulmonary embolism and was administered anticoagulation treatment, which lasted for 3 months but proved to be ineffective. subsequent re-examination via chest computed tomography further indicated multiple nodules in the left hilum and lung. therefore, the patient was hospitalized for lung aspiration biopsy, which led to the final diagnosis of pulmonary artery intimal sarcoma based on the pathological review.

Pulmonary artery intimal sarcoma: Case report of a patient managed with multimodality treatment and a comprehensive literature review

“…Our patient's FISH analysis was positive for MDM2 gene amplification, in concordance with the literature [3,4,21]. Targeting MDM2, either alone or in combination with other agents, could be a therapeutic approach, although MDM2 inhibitors are still undergoing clinical trials and are not yet clinically available [22].…”

“…PAIS is an extremely rare tumor with a probably underestimated incidence of 0.001-0.03% [1][2][3] due to challenges K in diagnosis. It mainly occurs in middle-aged adults with a broad of ages of onset between 13 and 86 [4]. It progresses aggressively if left untreated.…”

A rare clinical case of pulmonary artery sarcoma

“…Саркома легочной артерии (СЛА) -редкий вариант локализации злокачественной опухоли соединительной ткани. К настоящему моменту опубликовано около 400 статей по данной проблеме, при этом большинство из них представляют описание отдельных клинических случаев [1,2]. Клиническое течение заболевания на поздних стадиях прогрессирования часто имитирует симптоматику эмболии легочной артерии (ЛА).…”