A case report of acute severe paraquat poisoning and long-term follow-up

Yu, Guangcai; Kan, Baotian; Jian, Xiangdong; Wang, Jieru; Sun, Jing; Song, Chengzhen

doi:10.3892/etm.2014.1727

Cited by 25 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paraquat ( N , N -dimethyl-4,4 -bipyridinium dichloride) is a powerful pro-oxidant that generates mitochondrial reactive oxygen species in situ at the respiratory chain 9 – 11 . In humans, chronic environmental exposure to residues of paraquat used as pesticide has been linked to the development of Parkinson′s disease 12 , whereas in rare cases acute paraquat poisoning at higher dose has also been reported that leads to significant multi-organ toxicity and mortality 13 , 14 . In laboratory experiments, high doses of paraquat ( 20–80 mg/kg) have been broadly used as in rodents to reliably induce acute oxidative stress in the heart 15 – 18 and in the lung 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart

Dostal

Wood

Thomas

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The heart is sensitive to oxidative damage but a global view on how the cardiac proteome responds to oxidative stressors has yet to fully emerge. Using quantitative tandem mass spectrometry, we assessed the effects of acute exposure of the oxidative stress inducer paraquat on protein expression in mouse hearts. We observed widespread protein expression changes in the paraquat-exposed heart especially in organelle-containing subcellular fractions. During cardiac response to acute oxidative stress, proteome changes are consistent with a rapid reduction of mitochondrial metabolism, coupled with activation of multiple antioxidant proteins, reduction of protein synthesis and remediation of proteostasis. In addition to differential expression, we saw evidence of spatial reorganizations of the cardiac proteome including the translocation of hexokinase 2 to more soluble fractions. Treatment with the antioxidants Tempol and MitoTEMPO reversed many proteomic signatures of paraquat but this reversal was incomplete. We also identified a number of proteins with unknown function in the heart to be triggered by paraquat, suggesting they may have functions in oxidative stress response. Surprisingly, protein expression changes in the heart correlate poorly with those in the lung, consistent with differential sensitivity or stress response in these two organs. The results and data set here could provide insights into oxidative stress responses in the heart and avail the search for new therapeutic targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart

Dostal

Wood

Thomas

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Intentional or accidental ingestion is the major reason associated with PQ poisoning, which many fatalities have been reported each year3. Following the ingestion of large amounts of concentrated formulation, PQ has been shown to cause significant damage to multiple organs, including the lung, liver, kidney and myocardium, and the rapid development of multi-organ failure is often lead to fatality4. Moreover, even with the ingestion of smaller amounts, PQ is actively taken up through the highly developed polyamine uptake system, which ultimately leads to pulmonary fibrosis and respiratory failure5.…”

mentioning

confidence: 99%

Prognostic value of hematological parameters in patients with paraquat poisoning

Zhou

Zhang

Luo

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors. In the receiver operating characteristic (ROC) curve analysis, the NLR had an area of 0.916(95%CI, 0.877–0.954) and the optimal cut-off value was 10.57 (sensitivity, 86.70%; specificity, 83.51%; Youden’s index, 0.702). The leukocyte counts had an area of 0.849(95%CI, 0.796–0.902) and the optimal cut-off value was 13.15 × 103/mm3 (sensitivity, 77.10%; specificity, 83.50%; Youden’s index, 0.606). The neutrophil counts had an area of 0.878(95%CI, 0.830–0.925) and the optimal cut-off value was 10.10 × 103/mm3 (sensitivity, 83.80%; specificity, 79.38%; Youden’s index, 0.632). NLR, leukocyte and neutrophil counts are associated with the 30-day mortality, which may be useful and simple parameters in predicting the prognosis of PQ poisoning.

show abstract

“…In addition to lung damage, paraquat ingestion has been shown to injure other organs, but to a lesser extent. Acute fulminant poisonings are characterized by with multiple organ failure (cardiac, respiratory, renal, hepatic, adrenal, pancreatic, and neurological) ( 15 ). Therefore, gastric lavage is mandatory to reduce the absorption of paraquat.…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury in patients with paraquat intoxication; a case report and review of the literature

Asl¹,

Dadashzadeh²

2016

J Renal Inj Prev

View full text Add to dashboard Cite

Paraquat and diquat are classified as bipyridyl compounds not only leads to acute organ damage, but also to a variety of complications. Patients with severe paraquat-induced poisoning may succumb to multiple organ failure involving the circulatory and respiratory systems. Deliberate self-poisoning with paraquat continues to be a major public health concern in many developing countries. At present there is no specific antidote to paraquat poisoning, hence the need to more focus on prevention and in cases of poisoning aggressive decontamination to prevent further absorption. This article presented a 12-year-old male with acute kidney injury following the ingestion of paraquat in suicidal attempt and serves to explore the complications associated with paraquat poisoning and current recommended treatment

show abstract

A case report of acute severe paraquat poisoning and long-term follow-up

Cited by 25 publications

References 14 publications

Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart

Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart

Prognostic value of hematological parameters in patients with paraquat poisoning

Acute kidney injury in patients with paraquat intoxication; a case report and review of the literature

Contact Info

Product

Resources

About