A case of zosteriform Darier′s disease with seasonal recurrence

Gupta, Lalit; Garg, Anubhav; Khare, Ashok Kumar; Mittal, Asit

doi:10.4103/2229-5178.115523

Cited by 6 publications

(18 citation statements)

References 7 publications

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“…5 If genetic mosaicism involve the gonads, the mutation may be transmitted to descendants and potentially result in widespread disease. 4 , 5 In the case presented there was no similar history among siblings and daughters, suggesting a post-zygotic mutation with no gonadal involvement. Histological findings do not differ from those of widespread disease.…”

Section: Discussionmentioning

confidence: 81%

“…Type 1 phenotype of DD is the most common. 2 , 4 , 5 The skin surrounding the affected areas is normal. A post-zygotic somatic mutation would explain this variant.…”

Section: Discussionmentioning

confidence: 99%

“…In type II variant, there is heterozygotic mutation in the germline associated with somatic loss of heterozygosity of the wild-type allele in a segmental area, which leads to homo or heterozygosity and then to an exponential increase in severity. 2 , 4 …”

Section: Discussionmentioning

confidence: 99%

“…Since then, several variants of the localized disease were described: unilateral, linear, segmental or zosteriform. 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

“…In type II variant, patients present widespread disease with localized areas of more severe involvement. 2 , 4 …”

Section: Introductionmentioning

confidence: 99%

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Segmental Darier's disease: a presentation of difficult diagnosis

Medeiros

Alves

Trujillo

et al. 2015

An. Bras. Dermatol.

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Darier's disease is a rare autosomal dominant genodermatosis. It has an estimated prevalence of 1 in 55,000 to 100,000 individuals, regardless of gender. It is characterized by multiple keratotic papules on the seborrheic areas of the trunk, scalp, forehead and flexures, and the clinical picture is worsened by heat, sun exposure, perspiration and mechanical trauma. Histopathology observed loss of epithelial adhesion and abnormal keratinization. About 10% of cases present in the localized form of the disease. We report a case of segmental Darier's Disease Type I and discuss the main characteristics of this condition.

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Section: Discussionmentioning

confidence: 81%

“…Type 1 phenotype of DD is the most common. 2 , 4 , 5 The skin surrounding the affected areas is normal. A post-zygotic somatic mutation would explain this variant.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Since then, several variants of the localized disease were described: unilateral, linear, segmental or zosteriform. 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

“…In type II variant, patients present widespread disease with localized areas of more severe involvement. 2 , 4 …”

Section: Introductionmentioning

confidence: 99%

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Segmental Darier's disease: a presentation of difficult diagnosis

Medeiros

Alves

Trujillo

et al. 2015

An. Bras. Dermatol.

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Zosteriform dermatoses-A review

Hayderi¹,

Libon²,

Tassoudji³

et al. 2015

Glob Dermatol

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The zosteriform distribution of cutaneous lesions is a common disease pattern in dermatology. It describes a unilateral girdle-like distribution restricted to the sensitive nerve territory of a dermatome. Three different pathogenic pathways can lead to a zosteriform pattern. The neural pathway uses the axons of a nerve ganglion for viral transport to a specific dermatome. The arche type is Herpes Zoster (HZ) followed by Zosteriform Herpes Simplex Virus Type (HSV) I infection. The Blaschkoid pathway uses the Blaschko lines that represent embryonic migration patterns, often mimicking a dermatomal distribution, particularly on the trunk. The isotopic pathway defines a dermatosis that exclusively develops on the site of a previously healed HZ eruption.Before a zosteriform eruption, a history of prior HZ guides the diagnosis to the isotopic pathway, mainly represented bygranulomatous reactions followed by, among others, lichen planus, vasculitis and basal cell carcinoma. With no prior history of HZ recent eruptions orientate towards HZ and zosteriform HSV, whereas chronic eruptions should primarily evoke cutaneous metastases, principally from breast, ovary and lung carcinoma.This review summarizes the relevant literature and presents a clinical algorithm for the differential diagnosis of zosteriform dermatoses.Although Herpes Zoster (HZ) is the archetype of a zosteriform dermatosis, a large series of other infectious, neoplastic, inflammatory and miscellaneous dermatoses may also present a zosteriform distribution (Table 1). This paper reviews the three pathogenic mechanisms of the zosteriform pattern and proposes a diagnostic algorithm helping the dermatologist in the differential diagnosis of zosteriform dermatoses. Materials and methodsA PUBMED search was performed without restriction of publication date using the following keywords: Varicella Zoster Virus (VZV), varicella, herpes zoster, Herpes Simplex Virus (HSV), herpes simplex, genital herpes, zosteriform, zosteriform dermatoses, segmental, segmental dermatoses, dermatome, dermatomal distribution, isomorphand isotopic dermatoses. This research revealed 220 publications relevant to the subject and included for this review. PathogenesisCutaneous diseases presenting a zosteriform distribution answer to 3 different pathogenical pathways.

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Darier Disease – A Multi-organ Condition?

Bachar-Wikström

Wikström²

2021

Acta Derm Venereol

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Darier disease is a severe, rare autosomal dominant inherited skin condition caused by mutations in the ATP2A2 gene encoding sarcoendoplasmic reticulum Ca 2+ -ATPase isoform 2 in the endoplasmic reticulum. Since sarcoendoplasmic reticulum Ca 2+ -ATPase isoform 2 is expressed in most tissues, and intracellular calcium homeostasis is of fundamental importance, it is conceivable that other organs besides the skin may be involved in Darier disease. This review focusses on the association of Darier disease with other organ dysfunctions and diseases, emphasizing their common molecular pathology. In conclusion, Darier disease should be considered a systemic condition that requires systemic and disease mechanism targeted treatments.

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A case of zosteriform Darier′s disease with seasonal recurrence

Cited by 6 publications

References 7 publications

Segmental Darier's disease: a presentation of difficult diagnosis

Segmental Darier's disease: a presentation of difficult diagnosis

Zosteriform dermatoses-A review

Darier Disease – A Multi-organ Condition?

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