A Case of Toxic Hepatitis in a Worker Exposed to a Cleansing Agent Mainly Composed of Methylene Chloride

Ha, Bong Goo; Kim, Jin Seok; Yu, Jay Young; Woo, Kuck Hyun; Ham, Jung O.; Yoon, Seong Yong; Jang, Yong Seok; Jung, Sang Je

doi:10.35371/kjoem.2004.16.2.210

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Table 2 summarizes the occupational liver diseases reported in the Annals of Occupational and Environmental Medicine until recently. 8 9 13 14 15 16 17 18 Cases of toxic hepatitis caused by various xlink:types of organic solvents were reported in Korea, and there were 2 cases of toxic hepatitis caused by chloroform. The first reported case was suspected chloroform-induced hepatotoxicity in a laboratory engineer in 2012, 8 and the second case was hepatotoxicity of the 2 patients who worked in the clean room at a medical endoscopic manufacturer in 2014.…”

Section: Discussionmentioning

confidence: 99%

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

Hwang

Kim

2022

Ann Occup Environ Med

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Background Several cases of chloroform-induced hepatotoxicity have been reported worldwide, but only 2 cases have been reported in Korea. We encountered a case of toxic hepatitis due to chloroform exposure in February 2022 and report the diagnosis process and clinical findings. Case presentation A 38-year-old employee in charge of the coating after washing (degreasing) at an automotive parts manufacturer complained of jaundice and was diagnosed with acute toxic hepatitis. After the initial diagnosis, he continued to work, his symptoms worsened, and he was hospitalized for 8 days. Liver ultrasonography (elastography) revealed acute hepatitis. The washing agent contained chloroform, which was not listed on the materials safety data sheet, and the concentrations of chloroform in the workplace were up to 4.7 times the time-weighted average. Conclusions This patient showed typical toxic hepatitis with chloroform; further follow-up studies are required. Both employers and workers should be aware of information on toxic substances and take precautions to avoid exposure.

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Section: Discussionmentioning

confidence: 99%

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

Hwang

Kim

2022

Ann Occup Environ Med

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“…In Korea, DMF, dimethylacetamide (DMAc) and trichloroethylene (TCE) have been known as idiosyncratic agents which induce toxic hepatitis. Also, a case of toxic hepatitis of a worker who used methylene chloride as a degreasing agent was reported in the year of the report (2004) ( 6 ).…”

Section: Occupational Hepatic Disorders In Koreamentioning

confidence: 99%

Occupational Hepatic Disorders in Korea

Kim

2010

J Korean Med Sci

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Occupational hepatic disorders are classified into toxic hepatitis, viral hepatitis, and chemical-induced malignancy in Korea. Toxic hepatitis cases were reported in workers who were exposed to dimethylformamide, dimethylacetamide, or trichloroethylene. Pre-placement medical examination and regular follow-up are necessary to prevent the development of toxic hepatitis. Viral hepatitis was chiefly reported among health care workers such as doctors, nurses and clinical pathology technicians who could easily be exposed to blood. Preventive measures for these groups therefore include vaccination and serum monitoring programs. Hepatic angiosarcoma caused by vinyl chloride monomer (VCM) exposure is a very well known occupational disease and it has not been officially reported in Korea yet. Some cases of hepatocellular carcinoma were legally approved for compensation as an occupational disease largely by overwork and stress, but not supported by enough scientific evidence. Effort to find the evidence of its causal relationship is needed.

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Death Due to Acrylic Adhesive (Dichloromethane): A Case Report

Hyun¹,

Park²,

Park³

et al. 2022

Korean J Leg Med

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Deaths due to dichloromethane (DCM) poisoning are mainly caused due to accidents at industrial sites, and suicidal cases are known to be rare. Herein, we report a case of a 56-year-old man who worked as a technician and died after consuming DCM for suicidal motive. According to the investigations, he had left a recorded message on his phone for his wife, which suggested he committed suicide. At the scene, opened DCM and whiskey bottles were found; approximately 120 mL of the DCM was still in the bottle. No specific injuries were externally observed during the autopsy. Microscopic examination showed denudation of epithelium in the esophageal and gastric mucosa, and no inflammatory reaction proceeded. The denudation was accompanied by pulmonary edema, acute tubular necrosis in the kidneys, and microvesicular steatosis in the liver. The DCM was detected in blood, gastric contents, and nasal cavity fluid. The concentration of alcohol in the blood was found to be 0.487%. It was presumed that he died of acute DCM poisoning while drunk. In cases of suspicious acute and chronic DCM poisoning deaths, investigations of carboxyhemoglobin and the clinical chemistry of blood or body fluids are warranted to determine the cause and mechanism of death.

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A Case of Toxic Hepatitis in a Worker Exposed to a Cleansing Agent Mainly Composed of Methylene Chloride

Cited by 3 publications

References 12 publications

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process

Occupational Hepatic Disorders in Korea

Death Due to Acrylic Adhesive (Dichloromethane): A Case Report

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