Occupational Hepatic Disorders in Korea

Kim, Hyoung Ryoul; Kim, Tae Woo

doi:10.3346/jkms.2010.25.s.s36

Cited by 12 publications

(5 citation statements)

References 12 publications

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“…Furthermore, given the high incidence of liver diseases like alcoholic or viral hepatitis, it is difficult to demonstrate an occupational cause. Concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders resulting from occupational hepatotoxic agents (357). …”

Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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Liver cancer is the second leading worldwide cause of cancer-associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well-established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non-infective occupational risk factors for liver cancer is inconclusive. The relevance of liver disorders to occupational medicine lies in the fact that the majority of chemicals are metabolized in the liver, and toxic metabolites generated via metabolism are the predominant cause of liver damage. However, their non-specific clinical manifestations that are similar in a number of liver diseases make diagnosis difficult. Furthermore, concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders that result from occupational hepatotoxic agents and block the demonstration of an occupational cause. The identification of environmental agents that result in human cancer is a long and often difficult process. The purpose of the present review is to summarize current knowledge regarding the association of non-infective occupational risk exposure and HCC, to encourage further research and draw attention to this global occupational public health problem.

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Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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“…The amended article lists toxic hepatitis from chemicals and cirrhosis due to VC. In Korea, viral hepatitis and toxic hepatitis caused by trichloroethylene (TCE) and dimethylformamide (DMF) are well known [ 11 ]. Thus, the authors mainly describe chemically induced toxic hepatitis such as that due to TCE and DMF, and liver cirrhosis due to VC.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of viral hepatitis, healthcare workers are particularly at risk for HBV and HCV infections. The reported cases occurred in nurses, doctors, and pathology technicians in Korea, and the main cause of occurrence was accidental needlestick injuries [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Compensation for Work-Related Hematologic, Liver, and Infectious Diseases

Kim

Kang

2014

J Korean Med Sci

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Occupational diseases may be defined only medically or scientifically, and even then, their definition is not simple. However, compensable occupational diseases involve the additional layer of legal systems and social welfare policies as well. Their multifaceted nature makes determining the work-relatedness of these diseases more complex. Korea has established standards for the recognition of occupational diseases in Schedule 5 of the Enforcement Decree of the Labor Standards Act, and specific criteria for the recognition of occupational diseases are listed in Schedule 3 of the Enforcement Decree of the Industrial Accident Compensation Insurance Act. The new list of compensable occupational diseases comprises 13 articles as an open-ended system. The newly added articles pertain to lymphohematopoietic (Article 5) and infectious diseases (Article 9), as well as diseases of other target organs. Furthermore, the article on liver diseases (Article 8) has been partially revised. The new act has been changed to clarify the meaning as it has been presented in recent research. It is necessary to achieve agreement among concerned parties, including experts from the legal, medical, and social domains to resolve the issues of work-relatedness, causation, notion of aggravation, and so on for preparing a list and a process that are more reasonable.Graphical Abstract

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“…The toxic metabolites generated by these processes are the main causes of liver damage (36). Previous studies denoted that hepatocarcinogenesis is a long-term, multistage process in which multiple risk factors are involved (37).…”

mentioning

confidence: 99%