A Case of Symptomatic Idiopathic Thrombocytopenic Purpura During Mumps

Polat, Azız; Inan, Murat; Cakaloz, I; Karakuş, Yasin

doi:10.1080/08880010590921487

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…[3][4][5][6][7][8][9][10][11] ITP is known to occur after many types of infections, including numerous vaccine-preventable diseases. [12][13][14][15][16][17][18] In approximately two-thirds of ITP cases, there is a history of a preceding infectious illness in the days to weeks before ITP onset. 19 A subset of these children will have an identifiable virus, such as Epstein-Barr virus, varicella zoster virus, influenza virus, or HIV.…”

Section: Methodsmentioning

confidence: 99%

The Risk of Immune Thrombocytopenic Purpura After Vaccination in Children and Adolescents

et al. 2012

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WHAT'S KNOWN ON THIS SUBJECT: Studies on vaccine safety are crucial to the ongoing success of our national immunization program. ITP has a known association with MMR in young children, occurring in 1 in 40 000 doses. The risk after other childhood vaccines is unknown. WHAT THIS STUDY ADDS:This study found no increased risk of ITP after vaccines other than MMR in young children, confirmed an association of ITP with MMR, and also found that ITP may occur after certain other vaccines in older children.abstract BACKGROUND: The risk of immune thrombocytopenic purpura (ITP) after childhood vaccines other than measles-mumps-rubella vaccine (MMR) is unknown. METHODS:Using data from 5 managed care organizations for 2000 to 2009, we identified a cohort of 1.8 million children ages 6 weeks to 17 years. Potential ITP cases were identified by using diagnostic codes and platelet counts. All cases were verified by chart review. Incidence rate ratios were calculated comparing the risk of ITP in risk (1 to 42 days after vaccination) and control periods.RESULTS: There were 197 chart-confirmed ITP cases out of 1.8 million children in the cohort. There was no elevated risk of ITP after any vaccine in early childhood other than MMR in the 12-to 19-month age group. There was a significantly elevated risk of ITP after hepatitis A vaccine at 7 to 17 years of age, and for varicella vaccine and tetanus-diphtheria-acellular pertussis vaccine at 11 to 17 years of age. For hepatitis A, varicella, and tetanus-diphtheria-acellular pertussis vaccines, elevated risks were based on one to two vaccine-exposed cases. Most cases were acute and mild with no long-term sequelae.CONCLUSIONS: ITP is unlikely after early childhood vaccines other than MMR. Because of the small number of exposed cases and potential confounding, the possible association of ITP with hepatitis A, varicella, and tetanus-diphtheria-acellular pertussis vaccines in older children requires further investigation. 2 Since then, the association of live attenuated measles-mumps-rubella (MMR) vaccine and ITP has been well established. [3][4][5][6][7][8][9][10][11] ITP is known to occur after many types of infections, including numerous vaccine-preventable diseases. [12][13][14][15][16][17][18] In approximately two-thirds of ITP cases, there is a history of a preceding infectious illness in the days to weeks before ITP onset. 19 A subset of these children will have an identifiable virus, such as Epstein-Barr virus, varicella zoster virus, influenza virus, or HIV. 16 Because vaccines are designed to induce an immune response that mimics natural infection to produce immunologic protection, it is theoretically possible that vaccines besides MMR could trigger ITP. In addition, there have been case reports of ITP after other childhood vaccines, including hepatitis B vaccine (HBV), diphtheria-tetanuspertussis vaccine (DTP), and hepatitis A vaccine (Hep A). [20][21][22][23][24][25] However, the risk of ITP after childhood vaccines other than MMR is currently unknown.Known rare severe complica...

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