A case of spontaneous regression of hepatocellular carcinoma with bone metastasis

Sato, Yuzuru; Fujiwara, Kenji; Nakagawa, Shinya; Kanishima, Seiichi; Ohta, Yasuhiko; Oka, Yuji; Hayashi, Shigeki; Oka, Hiroshi

doi:10.1002/1097-0142(19850801)56:3<667::aid-cncr2820560339>3.0.co;2-s

Cited by 57 publications

(38 citation statements)

References 4 publications

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“…Chronic liver diseases, such as hepatitis and cirrhosis, increase the production of cytokines. 10 With such extensive cytokine production, clinical events such as transfusion, 11 infection, 12 and hemorrhage 4 can result in a rapid stimulation of the immune system. 1 In our patient, there were no such clinical episodes, but abstinence from alcohol might have improved his immunological function.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of a Large Hepatocellular Carcinoma with Portal Vein Tumor Thrombi: Report of a Case

et al. 2000

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A 65-year-old man with chronic hepatitis C showed a markedly elevated serum alpha-fetoprotein concentration. Computed tomography revealed a huge tumor occupying the entire right hepatic lobe. Three months later, the tumor regressed spontaneously from 12 cm to 7 cm in diameter without any medical treatment. A right hepatic lobectomy was performed 4 months after the initial diagnosis. The main tumor, located in the posterior inferior segment, was completely necrotic, and had a thick fibrous capsule. Many inflammatory cells had also infiltrated into the tumor. Only a small portion of a tumor thrombus in the portal vein and one of three intrahepatic metastases contained viable cancer cells. The tumor was found to be poorly differentiated hepatocellular carcinoma. Tumor regression may have been caused by a disturbance in hepatic circulation associated with the portal vein thrombus.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of a Large Hepatocellular Carcinoma with Portal Vein Tumor Thrombi: Report of a Case

et al. 2000

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“…1,2 The greatest numbers of such spontaneous regressions are reported in patients with neuroblastomas, renal cell carcinomas, malignant melanomas, and lymphomas/leukemias, 6 and the spontaneous regression of a primary malignant liver tumor is rare.…”

Section: Discussionmentioning

confidence: 99%

“…Nineteen cases of spontaneous HCC regression have been reported in the English-language literature, [1][2][3][4][7][8][9][10][11][12][13][14][15][16][17][18][19] and it is speculated that necrosis, caused by an ischemic disorder, and tumor immune activation are important causal factors. When we evaluated the causes of spontaneous regression in the 19 patients reported, 5 involved necrosis, 1,2,7-9 and 8 involved immunity.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that humoral immunity is related to spontaneous tumor regression, 1 but there have been no reports indicating that NK cells are involved. NK cells injure tumor cells nonspecifically, without sensitization by antigens and without the participation of a major histocompatibility complex.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Although immunological mechanisms may play important roles in spontaneous regression, 1,2,4 to our knowledge, there have been no reports of detailed investigations of such phenomena. In this report, we describe a patient with spontane-T. Nakai (*) · T. Shimomura · F. Hirokawa First Department of Surgery, National Sengokusou Hospital, 1191 Nagose, Kaizuka, Osaka 597-0042, Japan Tel.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous regression of recurrent hepatocellular carcinoma after TAE: possible mechanisms of immune mediation

Nakai¹,

Shimomura²,

Hirokawa³

2001

Int J Clin Oncol

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We report findings in a 76-year-old man who underwent a lateral segmentectomy of the liver for hepatocellular carcinoma in July 1996. In July 1997, transarterial embolization (TAE) was performed for recurrent tumors in the remnant liver. Augmentation of the tumors and an increase in protein induced by vitamin K absence or antagonist (PIVKA)-II level were noted in October 1997, and, although we recommended TAE again, the patient and his family refused further treatment. Subsequently, the patient was only observed, and, except for a small lesion that was probably a scar, no tumors were noted on image examinations in November 1998, and the PIVKA-II level had returned to a normal value at this time. Two years after the regression, the tumors appeared to be in complete spontaneous remission. This patient had no history indicative of ischemic necrosis, and levels of cellular surface markers for natural killer (NK) cells and NK cell activity showed high values, which suggested that tumor immunity was activated by some, unknown, mechanism.

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Spontaneous regression of primary intracranial germinoma

Ide

Jimbo²,

Yamamoto³

et al. 1997

Cancer

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RESULTS.A 21-year-old man was admitted to the study facility with acute onset size, tumor resection was not performed at that time. The patient was discharged and followed with MRI. The tumor continued to regress for more than 2 months.The patient was readmitted due to tumor regrowth, confirmed by MRI 4 months after the initial admission, despite the absence of symptom exacerbation. Two weeks later, the suprasellar portion of the tumor was resected through a right frontotemporal craniotomy. The histopathologic diagnosis was a germinoma. No concurrent tumors were found on whole body examination. The residual tumor gradually regressed after conventional radiation therapy and there has been neither tumor recurrence nor metastasis to date. CONCLUSIONS.Although the precise cause of the transient partial regression is unknown, this case indicates that, like their testicular counterparts, intracranial germinomas may on occasion spontaneously regress.

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A case of spontaneous regression of hepatocellular carcinoma with bone metastasis

Cited by 57 publications

References 4 publications

Spontaneous Regression of a Large Hepatocellular Carcinoma with Portal Vein Tumor Thrombi: Report of a Case

Spontaneous Regression of a Large Hepatocellular Carcinoma with Portal Vein Tumor Thrombi: Report of a Case

Spontaneous regression of recurrent hepatocellular carcinoma after TAE: possible mechanisms of immune mediation

Spontaneous regression of primary intracranial germinoma

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