“…4 Spontaneous regression has been reported in a variety of malignant cancers, including HCC, but this phenomenon is more frequently reported in neuroblastoma, malignant melanoma, and cancer of the kidney 4,[8][9][10][11] Various mechanisms have been proposed to explain spontaneous regression of HCC, with the most common being ischemic injury. 5,9 Biological factors, herbal medicines, immunological variations, high fever, reduction of nutrients necessary for tumor growth, blood transfusion, surgical trauma, vascular injury, cytokines, and endocrine factors have also been suggested to explain spontaneous regression, 6,[9][10][11][12][13] but none of the proposed mechanisms satisfactorily explain spontaneous regression of HCC.…”