A Case of Reversible Posterior Leukoencephalopathy Syndrome Caused by Transient Hypercoagulable State Induced by Infection

Yano, Yuichiro; Kario, Kazuomi; Fukunaga, Takashi; Ohshita, Tomohiko; Himeji, Daisuke; Yano, Masayuki; Nakagawa, Susumu; Sakata, Yoichi; Shimada, Kazuyuki

doi:10.1291/hypres.28.619

Cited by 17 publications

(14 citation statements)

References 26 publications

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“…A few cases of RPLS associated with hypercoagulable state (e.g. secondary to infection, thrombotic thrombocytopenic purpura) have been described [10][11] . The prothrombotic state associated with APS/CAPS might have played a role in the development of RPLS in our patient.…”

mentioning

confidence: 99%

Reversible Posterior Leukoencephalopathy Syndrome in Catastrophic Antiphospholipid Syndrome

Renard

Dutray

Quellec³

et al. 2007

Cerebrovasc Dis

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mentioning

confidence: 99%

Reversible Posterior Leukoencephalopathy Syndrome in Catastrophic Antiphospholipid Syndrome

Renard

Dutray

Quellec³

et al. 2007

Cerebrovasc Dis

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“…Moreover, endothelial activation induces a hypercoagulable state, which may lead to secondary cerebral ischaemia due to thrombosis. Thus, examination of the coagulation system is important in the diagnostic evaluation for PRES . In all three cases, d‐dimer was above the normal range, which could suggest a hypercoagulable state.…”

Section: Discussionmentioning

confidence: 88%

Three cases of posterior reversible encephalopathy syndrome with chronic kidney disease triggered by infection

et al. 2017

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Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological condition with diverse neurological manifestations. Many clinical factors are known causes of PRES, but only a few cases of PRES have been reported in patients with chronic kidney disease (CKD) and infectious disease. We describe three cases of PRES in patients with CKD triggered by various infectious diseases. Characteristic hyperintense signals on magnetic resonance imaging (MRI) indicating reversible vasogenic brain oedema in various parts of the brain were observed. To explain the pathophysiology of PRES, the hypertension/hyperperfusion and hypoperfusion/vasoconstriction theories have been proposed. Patients with CKD have many complications including uraemia, hypertension, and immunosuppression. Therefore, physicians should recognize that patients with CKD are at high risk of PRES triggered by infectious diseases and promptly diagnose PRES because immediate treatment of the triggers often leads to complete resolution.

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“…The relation between the patient's hypercoagulable state and PRES or the restricted diffusion pattern is unclear; scanty data are found in literature regarding the association between PRES and hypercoagulability [33], hypercoagulability may have been an added factor of endothelial injury in the patient.…”

Section: Discussionmentioning

confidence: 99%

A Horned Viper Bite Victim with PRES

Ibrahim

ElSefi

Ghanem

et al. 2017

Case Reports in Neurological Medicine

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Neurological complications of snake bites have been well documented in the literature as neuromuscular paralysis and cerebrovascular complications; posterior reversible encephalopathy syndrome was rarely described. A 23-year-old lady presented near full term of her pregnancy with a horned snake Cerastes cerastes bite; after successful delivery she started complaining of altered mental status and visual disturbance with ulceration over the site of the snake bite. On admission, the patient had Glasgow Coma Score of 12, blood pressure 130/80 mmHg, temperature 38°C, sinus tachycardia at 120 beats per minute, severe dehydration, and reduction in visual acuity to “hand motion” in both eyes with poor light projection and sluggish pupillary reactions. CT brain was not conclusive; MRI revealed features of PRES. Treatment was mostly supportive within one week; the patient regained consciousness; visual disturbance, however, persisted. This patient as well as the few previously described cases highlights PRES as a possible complication of snake bites.

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A Case of Reversible Posterior Leukoencephalopathy Syndrome Caused by Transient Hypercoagulable State Induced by Infection

Cited by 17 publications

References 26 publications

Reversible Posterior Leukoencephalopathy Syndrome in Catastrophic Antiphospholipid Syndrome

Reversible Posterior Leukoencephalopathy Syndrome in Catastrophic Antiphospholipid Syndrome

Three cases of posterior reversible encephalopathy syndrome with chronic kidney disease triggered by infection

A Horned Viper Bite Victim with PRES

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