Reversible Posterior Leukoencephalopathy Syndrome in Catastrophic Antiphospholipid Syndrome

Anti-phospholipid syndrome leading to digital ischaemia and rare organ complications in systemic sclerosis and related disorders

“…Our final case of SSc with secondary APS resulted in the rare PRES (also known as reversible posterior leukoencephalopathy syndrome (RPLS)). There have only been a small number of reported cases of PRES in association with primary and secondary APS, often in association with high titre ACL IgM, as was found in our case (40)(41)(42)(43). To our knowledge this is the first reported case of PRES occurring in the context of SSc and secondary APS.…”

Posterior Reversible Encephalopathy Syndrome with Stroke in Puerperal Woman with High Titer of Anti-Phospholipid IgM Antibody

“…A high titer of anti-phospholipid IgM antibody may have been associated with PRES, although, to the best of our knowledge, only 4 cases of PRES have been reported in patients with a high titer of anti-phospholipid antibody [5–8]. Systemic lupus erythematosus (SLE) is a well-known disease that is a risk factor for the occurrence of PRES [10, 11], and SLE is sometimes accompanied by anti-phospholipid antibodies [12].…”

Antiphospholipid Syndrome and Reversible Posterior Leukoencephalophaty Syndrome

“…As described by the authors, acute encephalopathy is a rare clinical diagnosis in APS, but we want to underscore the importance of this condition because of its potential reversibility in some cases. In particular, the occurrence of reversible posterior leukoencephalopathy syndrome (RPLS) in APS has been recently reported in 1 patient with a history of systemic lupus erythematosus and secondary APS who developed bilateral blindness with brain computed tomography findings of white matter hypodensity mostly in the posterior cerebral region (2).…”