A Case of Resection of Gastric Neurilemmoma That Could Be Diagnosed Preoperatively

Takahashi, Yoshiaki; Taniguchi, Masami; Tanaka, Shōji; Matsuda, Iwao; Yamazaki, Masanori; Yonekawa, Hajime

doi:10.3919/jjsa.70.724

Cited by 3 publications

(2 citation statements)

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“…Although neurogenic tumors of the digestive tract have been clearly recognized by immunohistochemical analysis using anti-S-100 protein, schwannoma of the stomach is relatively rare [2,3]. The preoperative differentiation of schwannomas from other (H&E, 9100).…”

Section: Discussionmentioning

confidence: 99%

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Schwannoma of the stomach with elevated preoperative serum carbohydrate antigen 19-9: report of a case

et al. 2011

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We herein report a case of a gastric schwannoma with elevated preoperative serum carbohydrate antigen 19-9 (CA19-9) (155.2 U/ml, normal range 0-36.9 U/ml). A 59-year-old Japanese man was admitted to our hospital for treatment of a submucosal tumor of the stomach detected by barium meal, upper gastrointestinal endoscopy, and computed tomography. Endoscopic examination revealed a 3-cm diameter submucosal tumor in the antrum of the stomach, but biopsy of the lesion was unable to confirm the diagnosis. Positron emission tomography to evaluate the malignant potential showed a high uptake of (18)F-fluorodeoxyglucose in the tumor. Laparoscopy-assisted distal gastrectomy was therefore performed. The histopathological findings of the surgical specimen revealed a benign gastric schwannoma, positive for S-100 protein. The postoperative serum CA19-9 levels gradually decreased and normalized. To the best of our knowledge, this is the first report of a gastric schwannoma with elevated serum CA19-9.

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Section: Discussionmentioning

confidence: 99%

“…Positive immunostaining for the S-100 protein indicates the Schwann cell origin of the tumor. The histological criteria for the diagnosis of a malignant schwannoma are based on the presence of mitotic figures and nuclear atypia [3].…”

Section: Introductionmentioning

confidence: 99%