A Case of Primary Carcinoma of the Bladder With Metastasis to the Brain

Lower, William E.; Watkins, Ralph M.

doi:10.1097/00000441-192403000-00007

Cited by 12 publications

(2 citation statements)

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“…3,4 Other common metastasis sites include liver, adrenal gland, and intestine. 5,6 Intracranial metastasis in this context was first described by Lower and Watkins in 1924, 7 and, although it remains an infrequent clinical manifestation, the number of central nervous system lesions from bladder cancer has increased since 1980. 8 When the CNS is involved, it frequently occurs as a late event in the course of bladder carcinoma, such as a patient with advanced stage of disease.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Single Metastases from Bladder Transitional Cell Carcinoma: A Case Report

et al. 2016

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Cerebral metastasis is the most common cancer in the Central Nervous System (CNS); however, the bladder is a rare primary origin. The incidence of bladder metastases to the brain tissue has slightly increased in the past decades, with a few case reports published in medical literature, but not in Brazil. The authors describe a case of a female with prior diagnosis and treatment of transitional cellular cancer, without signs or symptoms of local or disseminated relapse, who suddenly developed clinical signs of cerebellum impairment. The patient was submitted to neurosurgical procedure with good outcome, followed by oncologic adjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Cerebellar Single Metastases from Bladder Transitional Cell Carcinoma: A Case Report

et al. 2016

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“…Incidence of BC brain metastases in the precisplatin era was low, ranging from <1% to 7% based on autopsy series and radiotherapy trials on treatment of brain metastases, with most series closer to 1-3% [23][24][25][26][27][28][29]. Clinical series in the pre-cisplatin era likely underestimated the incidence of BC brain metastases due to limitations in diagnostic imaging prior to the widespread use of high-quality computerized tomography (CT) and magnetic resonance imaging (MRI) scans and because patients were not scanned unless they developed symptoms.…”

Section: Incidence Of Bladder Cancer Brain Metastasesmentioning

confidence: 97%

Review: Brain Metastases in Bladder Cancer

Brenneman

Christodouleas

Sargos

et al. 2020

BLC

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Nearly 50% of bladder cancer patients either present with metastatic disease or relapse distantly following initial local therapy. Prior to platinum-based chemotherapy, the incidence of bladder cancer central nervous system metastases was approximately 1%; however, their incidence has increased to 3–16% following definitive treatment as platinum-based regimens have changed the natural history of the disease. Bladder cancer brain metastases are generally managed similarly to those from more common malignancies such as non-small cell lung cancer, with surgery +/–adjuvant radiotherapy, or radiotherapy alone using stereotactic radiosurgery or whole brain radiotherapy. Limited data suggest that patients with inoperable urothelial carcinoma brain metastases who are not candidates for stereotactic radiosurgery may benefit from shorter whole brain radiation therapy courses compared to other histologies, but data is hypothesis-generating. Given improvements in the efficacy of systemic therapy and supportive care strategies for metastatic urothelial carcinoma translating in improved survival, the incidence of intracranial failures may increase. Immune checkpoint blockade therapy may benefit cisplatin-ineligible metastatic urothelial carcinoma patients as first-line therapy; however, the effectiveness of immune checkpoint blockade to treat central nervous system disease has not been established. In this review, we discuss the incidence and management of bladder cancer brain metastases and considerations regarding variations in management relative to more commonly encountered non-urothelial histologies.

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Die Gewächse der ableitenden Harnwege (Nierenbecken, Harnleiter und Blase)

Hückel¹

1934

Harnorgane Männliche Geschlechtsorgane

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A Case of Primary Carcinoma of the Bladder With Metastasis to the Brain

Cited by 12 publications

References 0 publications

Cerebellar Single Metastases from Bladder Transitional Cell Carcinoma: A Case Report

Cerebellar Single Metastases from Bladder Transitional Cell Carcinoma: A Case Report

Review: Brain Metastases in Bladder Cancer

Die Gewächse der ableitenden Harnwege (Nierenbecken, Harnleiter und Blase)

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