Cerebellar Single Metastases from Bladder Transitional Cell Carcinoma: A Case Report

Abstract

Cerebral metastasis is the most common cancer in the Central Nervous System (CNS); however, the bladder is a rare primary origin. The incidence of bladder metastases to the brain tissue has slightly increased in the past decades, with a few case reports published in medical literature, but not in Brazil. The authors describe a case of a female with prior diagnosis and treatment of transitional cellular cancer, without signs or symptoms of local or disseminated relapse, who suddenly developed clinical signs of cerebellum impairment. The patient was submitted to neurosurgical procedure with good outcome, followed by oncologic adjuvant treatment.

Metastatic Urothelial Cell Carcinoma Presenting as an Isolated Malignancy to the Posterior Fossa: A Case Report and Review on the Literature

“…The vertebral venous plexus is a giant network of interconnecting valveless veins along the vertebral column, extending from the sacrum all the way to the foramen magnum. Thus, metastasis via this route bypasses the lungs, liver, and other visceral organs traveling directly into the intracranial venous sinus at the level of the foramen magnum [ 3 , 18 ]. This is speculated to be the route of metastasis in most cases of single isolated CNS metastasis secondary to bladder UCC.…”

“…The literature estimates that distal metastasis occurs in 10%-29% of patients with bladder UCC. The most common sites of distal metastasis, in order of most to least prevalent, are the lymph nodes, liver, peritoneum, lungs, and bones [ 2 , 3 ]. Metastasis to the central nervous system (CNS) can occur but is extremely rare [ 1 ].…”