A Case of Post-Radiotherapy Gastritis: Radiation Does Not Explain Everything

Abrunhosa-Branquinho, André; Barata, Pedro C.; Vitorino, Emília; Oliveira, E.Rissato de; Bujor, L.; Jorge, Marília

doi:10.1159/000371653

Cited by 107 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with radiation‐induced soft‐tissue necrosis, HBO‐induced neovascularization commonly reaches a plateau effect after approximately 20 treatments, consistent with the clinical improvement and cessation of gastrointestinal bleeding noted in our case after 25 treatments 7. HBOT is infrequently reported as a therapeutic option for RIHG 1,8,9. Banerjee et al1 reported an adult patient with refractory radiation‐induced gastritis who received 30 HBOT sessions, after which melena stopped, and the patient did not require further transfusion.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient

Johnson‐Arbor

Serrano

et al. 2021

JPGN Reports

View full text Add to dashboard Cite

Radiation-induced hemorrhagic gastritis is a serious and rare complication of radiation therapy. Optimal therapies in the pediatric population are not well established. We report a 2-year-old female diagnosed with rhabdomyosarcoma who developed hemorrhagic gastritis following chemotherapy and radiation therapy. The patient presented with acute onset anemia, hematemesis, and melena. Endoscopies revealed circumferential ulceration at the pylorus with spontaneous oozing that failed to respond effectively with multimodal medical and endoscopic therapies. Following hemodynamic stabilization, the patient was treated with hyperbaric oxygen therapy with excellent clinical response of the bleeding. Further research on the benefit of hyperbaric oxygen therapy is warranted to determine if this treatment can reduce the incidence of gastrointestinal complications in patients who have received radiation therapy.

show abstract

Section: Discussionsupporting

confidence: 84%

“…7 HBOT is infrequently reported as a therapeutic option for RIHG. 1 , 8 , 9 Banerjee et al 1 reported an adult patient with refractory radiation-induced gastritis who received 30 HBOT sessions, after which melena stopped, and the patient did not require further transfusion.…”

Section: Discussionmentioning

confidence: 99%

The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient

Johnson‐Arbor

Serrano

et al. 2021

JPGN Reports

View full text Add to dashboard Cite

show abstract

Low-grade-/High-grade-Synovialitis

et al. 2006

View full text Add to dashboard Cite

show abstract

Synovialitis-Score: Histopathologisches Graduierungsschema rheumatischer und nicht-rheumatischer Synovialitiden

et al. 2005

View full text Add to dashboard Cite

Standardization of the histopathological assessment of synovial membrane specimens might facilitate the diagnosis of chronic rheumatic and non-rheumatic joint diseases. We would like to propose a histological graduation scheme ("synovialitis score"), which is applicable to all forms of synovitis, irrespective of its etiology. This score evaluates the three compartments of chronic synovialitis [enlargement of lining cell layer, activation of synovial stroma (i. e. resident cells), leukocytic infiltrate] semiquantitatively (from 0=absent to 3=strong). Each compartment is graded separately, and the sum resembles the synovialitis score, which is interpreted as follows: 0-1: no synovialitis, 2- 3: slight synovialitis, 4-6: moderate synovialitis, 7-9: strong synovialitis (for sample photos see also www.charite.de/ch/patho/Webpage/pages/forschung/arbeitsgruppen/ag-krenn/index.htm). A total of 483 synovial specimens (resections n=462, biopsies n=21) were graded by two independent observers. Clinical diagnoses were osteoarthrosis (OA; n=153), posttraumatic arthritis (PtA; n=31), rheumatoid arthritis (RA; n=239), psoriatic arthritis (PsA; n=32), reactive arthritis (ReA; n=7), and controls (Co, n=21) from necropsies of patients without joint damage. The correlation between two observers was high (p<0.001). The correlation coefficient between the different samples from the same joint in n=112 cases was between 0.86 and 0.95. Median synovialitis scores when correlated with clinical diagnoses were: Co 0.5, OA 2, PtA 3, PsA 3, ReA 4, RA 5. The differences in scores between Co and all other groups were highly significant (p<0.001). A synovialitis score of 4 points and more was strongly associated with rheumatic joint diseases (sensitivity 73%, specificity 86%). Validation of the synovialitis score by gene expression data showed good correlations for the lining cell enlargement with MMP1 (0.685), for the leukocytic infiltrate with CD3 (0.754) and CD138 (0.744) and for the stroma activation with CD14 (0.744). The proposed synovialitis score is based on well definable histopathologic criteria and contributes to the diagnosis of rheumatic and non-rheumatic joint diseases.

show abstract

A Case of Post-Radiotherapy Gastritis: Radiation Does Not Explain Everything

Cited by 107 publications

References 11 publications

The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient

The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient

Low-grade-/High-grade-Synovialitis

Synovialitis-Score: Histopathologisches Graduierungsschema rheumatischer und nicht-rheumatischer Synovialitiden

Contact Info

Product

Resources

About