A case of orbital extra-adrenal paraganglioma in a quarter horse

Tomassini, Letizia Tomassini; Pettinari, Ilaria; Lepri, Elvio; Gialletti, Rodolfo; Bellezza, Enrico; Leonardi, Leonardo

doi:10.24070/bjvp.1983-0246.v12i2p53-57

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…In contrast to medulloepitheliomas, retinoblastomas are mainly composed of sheets of undifferentiated neuroepithelial cells (7,20). The main histological characteristic of medulloepithelioma is the formation of the Flexner-Wintersteiner rosettes (7), therefore, immunohistochemistry could be performed to confirm the suspicion of medulloepithelioma and exclude the differential diagnoses (23,29) as the neuroendocrine carcinomas and paragangliomas (26).…”

Section: Discussionmentioning

confidence: 99%

A case of metastatic non-teratoid ocular medulloepithelioma in an adult horse

Nascimento¹,

Carvalho²,

Nonato³

et al. 2021

BJVP

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This case reports an eight-years-old horse that presented a unilateral tumor in the left ocular orbital region diagnosed on the basis of clinical signs, gross anatomopathological and histopathological investigations. The affected area was exenteration and submitted to histopathological evaluation and was diagnosed as a non-teratoid medulloepithelioma. This is a rare ocular neoplasm that usually affects young individuals – and was composed by neuroepithelium arranged in tubules and Flexner-Wintersteiner rosettes without presence of heteroplastic components. The animals died and was submitted to post-mortem evaluation, revealing presence of medulloepithelioma metastases at the internal region of the head, lymph nodes, lungs, and liver. This neoplasm usually presents a benign frame; however, the case herein described shows that it can be highly malignant and aggressive since it can cause extensive lesions and spread metastases to visceral organs.

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Section: Discussionmentioning

confidence: 99%

A case of metastatic non-teratoid ocular medulloepithelioma in an adult horse

Nascimento¹,

Carvalho²,

Nonato³

et al. 2021

BJVP

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“…In animals, PGLs are very rare neuroendocrine tumors and the cases described in the literature have been found in dogs [ 7 , 23 , 24 ] and horses [ 6 , 9 , 10 , 25 , 26 , 27 ] but only occasionally in cats or other animals. In fact, to the authors’ knowledge, only one case of paraganglioma of the cauda equina region of a cat has been described [ 3 ], but this neoplasm in the orbit of a cat has never been described.…”

Section: Discussionmentioning

confidence: 99%

“…The paraganglion system is composed of a large network distributed symmetrically in the para-axial body regions within different tissues [ 5 ]. It is either grouped in cell aggregates, or in single individual cells, representing an important constituent of the neuroendocrine system [ 6 ], and it can be classified into four groups: the branchiomeric paraganglia (arteries and cranial nerves of head and cervical region), intravagal paraganglia—along the vagus nerve, the aortic-sympathetic paraganglia, visceral autonomic paraganglia (interatrial septum, liver hilum, duodenum, urinary bladder) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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A First Case Report of Orbital Extra-Adrenal Paraganglioma in Cat

Leonardi

Rizac

Pettinari

et al. 2021

Veterinary Sciences

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Paraganglioma is a rare neuroendocrine neoplasm originating from paraganglia and consisting of neuroendocrine cells of the sympathetic and parasympathetic nervous system. Extra-adrenal paraganglioma occurs with a low incidence in both humans and animals. This report presents the first case of paraganglioma in a cat with orbital primary location. An 18-year-old spayed female European domestic shorthair cat of 3.60 kg body weight was evaluated in a private veterinary clinic in Perugia, Italy, for a pronounced exophthalmos of the right eye. The cat underwent surgery for the enucleation of the right eye and of the mass. The biopsy samples of the removed tissue were fixed in 10% buffered neutral formalin for histological and immunohistochemical evaluations. Therefore, specific markers were used for immunohistochemical investigations, such as anti-neuron specific enolase (NSE), anti-synaptophysin, anti-glial fibrillary acid protein, anti-cytokeratin and anti-chromogranin. The results of these investigations allowed establishing the final diagnosis of ocular extra-adrenal paraganglioma of the cat.

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“…Primary intraocular tumors are a rare event in horses, with medulloepitheliomas (i.e., tumors of primitive neuroepithelium) and uveal melanomas being the most commonly reported neoplasms [ 4 ], and a single case of an orbital paraganglioma documented [ 22 ]. In the present case, the neoplasm was poorly differentiated, but with the aid of IHC, a poorly pigmented or amelanotic melanoma could be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

Brocca

Centelleghe

Padoan³

et al. 2020

Animals

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A 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. Subsequently, the mare was presented with rapidly spreading multiple subcutaneous masses and, at the onset of neurological signs, was humanely euthanized and subjected to a complete post mortem examination. The necropsy confirmed the presence of numerous widespread masses in the subcutaneous tissue, several internal organs, and mammary gland. Histological and immunohistochemical (IHC) examinations were performed on all masses, allowing the diagnosis of mammary carcinoma with several visceral and subcutaneous metastases. Considering the post mortem findings, the second intraocular mass was submitted to histological and IHC re-evaluation to differentiate it from an intraocular metastasis of the mammary carcinoma. The results of the histological and IHC analyses confirmed the diagnosis of neuroepithelial tumor relapse. This is the first case of a metastatic mammary carcinoma concurrent with a recurrent intraocular neuroepithelial tumor in a mare. This case was a challenge for both clinicians and pathologists involved and highlighted the importance of post mortem and IHC evaluations.

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A case of orbital extra-adrenal paraganglioma in a quarter horse

Cited by 3 publications

References 4 publications

A case of metastatic non-teratoid ocular medulloepithelioma in an adult horse

A case of metastatic non-teratoid ocular medulloepithelioma in an adult horse

A First Case Report of Orbital Extra-Adrenal Paraganglioma in Cat

Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor

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