A case of oral mycosis fungoides successfully treated by combination of alemtuzumab and chemotherapy

Postorino, Massimiliano; Pupo, Livio; Provenzano, Ida; Principe, Maria Ilaria Del; Buccisano, Francesco; Franceschini, Luca; Rizzo, Manuela; Nasso, Daniela; Meconi, Federico; Onnis, I.; Vaccarini, Sara; Zizzari, Annagiulia; Anemona, Lucia; Mauramati, Simone; Bruno, Ernesto; Amadori, Sergio

doi:10.1007/s00277-015-2503-z

Cited by 6 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were only 42 reported cases of oral MF including our patient; most cases of MF in the oral cavity have been described as affecting the tongue and palate, as in our patient [3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20]. …”

Section: Discussionmentioning

confidence: 75%

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

et al. 2016

View full text Add to dashboard Cite

Extracutaneous involvement in mycosis fungoides (MF) carries a poor prognosis. Oral and gastrointestinal (GI) tract lesions are both rare locations of disease. We describe the clinical findings of one case with oral and GI MF complicated by perforation after systemic antineoplastic treatment, and review the relevant literature. The patient had a 1-year history of MF before development of tongue and palate tumors. He was treated with local electron beam radiation, but re-presented to the hospital after what was found to be small intestine perforation following systemic antineoplastic therapy. The case reveals key insights into the progression and complications of lymphomas with GI tract involvement.

show abstract

Section: Discussionmentioning

confidence: 75%

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The most common type reported was MF (CD4 + CD8 − ), followed by double-positive CD4 + CD8 + MF. Only 6 cases of oral MF reported large cell transformation [ 54 – 56 , 64 ]. Case 2 in this report will be the seventh case.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…There are a total of 43 cases that explicitly mention prior therapies received before the development of oral lesions. Of these, 13 cases (30%) received TSEBT (TSEBT group) [ 27 , 28 , 31 , 35 , 36 , 38 , 44 – 46 , 54 , 55 , 57 ] and 30 cases (70%) did not receive TSEBT (non-TSEBT group) [ 13 , 15 , 16 , 19 , 21 , 22 , 26 , 29 , 33 , 34 , 36 , 37 , 39 , 42 , 43 , 45 , 47 – 50 , 52 , 53 , 56 , 58 , 60 – 63 ] prior to developing oral lesions. The time for oral CTCL to develop after the initial presentation of CTCL was 5.4 years and 7.3 years for the TSEBT and the non-TSEBT groups, respectively.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

Alexander-Savino¹,

Boye-Doe²,

Bowers³

et al. 2023

Case Rep Dermatol

View full text Add to dashboard Cite

Oral and laryngeal cutaneous T-cell lymphoma (CTCL) is rare and usually associated with poor prognosis. Here, we discuss 2 cases of oral CTCL that developed in heavily pretreated patients and provide a review of the literature. The first case is of a 46-year-old African American male with rapidly progressive disease, presenting with a lesion on his hard palate 6 months after being diagnosed with a CD4+CD8+ CTCL. His cutaneous disease was widespread with tumors on >80% of his body surface area. Unfortunately, the patient died 2 ½ years after his CTCL diagnosis and 7 months after developing the oral CTCL lesion. The second case is of a 38-year-old African American male with stage IIb CD3+CD4+CD30+ mycosis fungoides (MF), who developed a tumor on the hard palate 6 months after diagnosis. He received palliative radiation to the oral lesion and multiple lines of systemic therapy for pulmonary, laryngeal, esophageal, and gastric involvement. Biopsy of the gastric lesions showed a CD30+ T-cell lymphoma with the same clonal peak as in his skin but with large cell transformation. Brentuximab vendoin was started, and the patient is now in complete remission, 30 months later. From the 76 cases of oral CTCL that have been reported in the English language, six were of transformed MF. The most common sites affected were the tongue and palate, and the most common presentation were erythematous or ulcerated tumors, plaques, or nodules associated with dysphagia and pain. Oral CTCL typically occurs years after the initial diagnosis of CTCL and portend a poor prognosis with an average survival of just over 1 year after development of oral lesions.

show abstract

“…bexarotene) or biologic therapies (e.g. anti-CD52 monoclonal antibody) [5,21,22]. Cutaneous MF has a relatively indolent course and is slowly progressive with a median survival of 8-10 years [4,5], however, MF presenting in the oral cavity is typically a sign of advanced disease with a more aggressive course (mortality rate is ~50% at 1 year with the majority of patients dying by the 3rd year) [6,9,12,15].…”

Section: Discussionmentioning

confidence: 99%

Large Cell Transformation of Oral Mycosis Fungoides

Sultan

Mostoufi

Papadimitriou

et al. 2017

Head and Neck Pathol

View full text Add to dashboard Cite

Mycosis fungoides (MF) accounts for approximately 50% of all primary cutaneous lymphomas. MF occurrence in the oral cavity is extremely rare with approximately 45 cases reported to date. We present a case of a 68 year-old man with a raised nodular lesion of the ventral tongue with clinical impression of irritational fibroma. Histopathologic and immunohistochemical (IHC) examination revealed a phenotype consistent with MF with large cell transformation in the context of Sezary syndrome. The histological diagnosis of oral MF requires a high index of suspicion and IHC panel to rule out large cell transformation. To our knowledge, only four cases of large cell transformation of oral MF have been reported in the English literature. The clinical and histopathologic features of a rare case of intra-oral MF with large cell transformation are exemplified in this article.

show abstract

A case of oral mycosis fungoides successfully treated by combination of alemtuzumab and chemotherapy

Cited by 6 publications

References 7 publications

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

Large Cell Transformation of Oral Mycosis Fungoides

Contact Info

Product

Resources

About