A Case of New Variant COVID-19 First Emerging in South Africa Detected in Airplane Pilot — Guangdong Province, China, January 6, 2021

Chen, Fengjuan; Li, Bosheng; Hao, Peter; Song, Yang; Xu, Wenbo; Liu, Nankun; Lei, Chunliang; Ke, Changwen

doi:10.46234/ccdcw2021.007

Cited by 16 publications

(10 citation statements)

References 2 publications

(2 reference statements)

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“…The sources of SARS-CoV-2 infections for several epidemics inside China after the wave of Wuhan outbreak have been found previously. For instance, imported cases and related transmission were caused by flights (7), carried by crewmembers (8), carried by community members (9), and spread in hospital settings (10). Increasing awareness and remaining vigilant will help prepare the necessary emergency response resources and prevent the uncontrolled spread of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Zhou¹,

Nie²,

Zhao³

et al. 2021

China CDC Weekly

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Section: Discussionmentioning

confidence: 99%

Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Zhou¹,

Nie²,

Zhao³

et al. 2021

China CDC Weekly

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“…The SARS-CoV-2 WT strain (IVCAS 6.7512) and B.1.351 strain (NPRC 2.062100001)( 24 ) were provided by the National Virus Resource, Wuhan Institute of Virology, Chinese Academy of Sciences, the SARS-CoV-2 B.1.1.7 strain (240108) was provided by HUBEI PROVINCIAL CENTR FOR DISEASE CONTROL AND PREVENTION. All SARS-CoV-2 authentic virus related experiments (S01321010A) were approved by the Biosafety Committee Level 3 (ABSL-3) of Wuhan University, Wuhan Institute of Virology and HUBEI PROVINCIAL CENTR FOR DISEASE CONTROL AND PREVENTION.…”

Section: Methodsmentioning

confidence: 99%

Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan

Liu

Xiong

Mei

et al. 2021

Preprint

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Most COVID-19 patients can build effective humoral immunity against SARS-CoV-2 after recovery . However, it remains unknown how long the protection can maintain and how efficiently it can protect people from the reinfection of the emerging SARS-CoV-2 variants. Here we evaluated the sera from 248 COVID-19 convalescents around one year post-infection in Wuhan, the earliest epicenter of SARS-CoV-2. We demonstrated that the SARS-CoV-2 immunoglobulin G (IgG) maintains at a high level and potently neutralizes the infection of the original strain (WT) and the B.1.1.7 variant in most patients. However, they showed varying degrees of efficacy reduction against the other variants of concern (P.1, B.1.525, and especially B.1.351) in a patient-specific manner. Mutations in RBD including K417N, E484K, and E484Q/L452R (B.1.617) remarkably impair the neutralizing activity of the convalescents' sera. Encouragingly, we found that a small fraction of patients' sera showed broad neutralization potency to multiple variants and mutants, suggesting the existence of broadly neutralizing antibodies recognizing the epitopes beyond the mutation sites. Our results suggest that the SARS-CoV-2 vaccination effectiveness relies more on the timely re-administration of the epitope-updated vaccine than the durability of the neutralizing antibodies.

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“…G21974T, This is the fourth recent detection of a major international variant following the detection of the United Kingdom 501Y.V1 variant, the South African 501Y.V2 variant, and the Nigerian B.1.525 variant in Guangdong (7)(8)(9). The transmissibility and pathogenicity of these mutant variants urgently need further study.…”

Section: C21638tmentioning

confidence: 99%

Two Imported Cases of New Variant COVID-19 First Emerging from Brazil — Guangdong Province, China, April 30, 2021

Zhao

Song

et al. 2021

China CDC Weekly

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On April 15, 2021, a 62-year-old male (Patient A, XG4122) and a 58-year-old female (Patient B, XG4123) travelled from Canada via airplane and were transferred to a central isolation hotel after being tested by the laboratory of Guangzhou Customs using nose swab tests for coronavirus disease 2019 . The results for both patients returned COVID-19 positive and the couple were transported to the Guangzhou Eighth People's Hospital for isolated treatment by ambulance on April 16, 2021. Patient A had inflamed lungs while Patient B had mild inflammation in her lungs according to the chest computed tomography (CT) examination. Both of their 28 close contacts underwent centralized isolation and medical observation.On April 21, 2021, Guangdong Provincial CDC received the samples and began virus isolation and gene sequencing analysis. On April 27, 2021, the 2 samples were sequenced using Nanopore GridION. On April 30, 2021, the sequencing analysis concluded that the 2 virus genomes belonged to lineage P.1, 20J/501Y.V3, which was first found in four Brazilians after a routine check at Japan's Haneda Airport in late December 2020. The variant was then widely spread to Manaus in the northern State of Amazona in Brazil. The Brazil variant has been reported in 40 different countries as of April 30, 2021(1).Compared with the Wuhan reference sequence (EPI_ISL_402119) (2-3), the strain from Patient A (XG4122) displayed 33 nucleotide variation sites (C241T,

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A Case of New Variant COVID-19 First Emerging in South Africa Detected in Airplane Pilot — Guangdong Province, China, January 6, 2021

Cited by 16 publications

References 2 publications

Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan

Two Imported Cases of New Variant COVID-19 First Emerging from Brazil — Guangdong Province, China, April 30, 2021

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