A Case of New Variant COVID-19 First Emerging in South Africa Detected in a Security Guard at the Isolation Point — Shenzhen, China, January 23, 2021

Abstract

The strains associated with specific outbreaks in China are marked in red. The South African 501Y.V2 variants are highlighted with yellow color and the Guangdong imported 501Y.V2 variant are marked in red, and the Shenzhen 20H/501.Y.V2 variant are exhibited with the red dots. The UK VUI-202012/01 variants are highlighted in blue. The Wuhan reference strain is marked in gray. The S(A)- or L(B)-lineage and sublineages of the COVID-19 virus were marked and colored on the right.

Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2

“…route with adenovirus (Ad5) expressing hACE2 and, 5 days later, challenged intranasally with prototypic SARS-CoV-2 (hCoV-19/ China/CAS-B001/2020 strain). The other four mice in each group were challenged directly with Beta SARS-CoV-2 variant (GDPCC-nCoV84 strain) (Meng et al, 2021) via i.n. route.…”

“…For experiments conducted in Institute of Microbiology, Chinese Academy of Science (IMCAS), prototype SARS-CoV-2 (hCoV-19/ China/CAS-B001/2020, GISAID: EPI_ISL_514256-7) was propagated in Vero E6 cells and titrated by tissue culture infectious dose 50 (TCID 50 ) assay on Vero E6 cells. For experiments conducted in Chinese Center for Disease Control and Prevention (China CDC), prototype SARS-CoV-2 (IVDC-QD-11-2P2), Beta variant (GDPCC-nCoV84, NPRC: 2.062100001) (Meng et al, 2021) and Omicron variant (BA.1, NPRC: 2.192100005) was propagated in Vero cells and titrated by TCID 50 assay on Vero cells. For experiments conducted in Institute of Medical Biology, Chinese Academy of Medical Sciences (IMBCAMS), prototype SARS-CoV-2 (GDPCC-nCoV27), Alpha variant (NPRC: 2.…”

SARS-CoV-2 Variants: Surveillance, Evaluation, and Challenges

“…SARS-CoV-2 VOCs have continuously been imported into China [21–30] . The nucleic acid detection kits recommended for use in China (mainly for dual or triple targets of ORF1ab, N, and E) can detect VOC infections.…”

“…The next-generation sequencing technology can quickly determine the viral lineage and variants. The B.1.1.7 (20I/501Y.V1) variants were reported in Beijing, Shanghai, Shandong, and other areas, [21,22] while cases of the B.1.351 (20C/501Y.V2) were reported in Guangdong and Shandong [23,24] . Meanwhile, the B.1.617 variant was recently detected in Chongqing, Sichuan, Zhejiang, Shanghai, Beijing, Guangdong, and Yunnan [25–28] .…”

“…SARS-CoV-2 VOCs have continuously been imported into China. [21][22][23][24][25][26][27][28][29][30] The nucleic acid detection kits recommended for use in China (mainly for dual or triple targets of ORF1ab, N, and E) can detect VOC infections. The next-generation sequencing technology can quickly determine the viral lineage and variants.…”