Infections caused by Edwardsiella tarda (E. tarda), particularly musculoskeletal ones, have rarely been reported in humans. Here, we report the case of a 77-year-old man with thoracic spondylitis caused by E. tarda. The patient had back pain without neurological symptoms for several weeks. He had a history of diabetes, prostate cancer, and pancreatic cancer with hepatic metastasis. Computed tomography (CT) revealed endplate erosion at the T1/2 disk (Fig. 1a), whereas magnetic resonance imaging (MRI) revealed bone edema in the T1-2 vertebrae and fluid accumulation in the T1/2 disk (Fig. 1b, c). Furthermore, laboratory examination revealed hyperleukocytosis and high C-reactive protein levels.Subsequently, empiric antimicrobial therapy with intravenous piperacillin/tazobactam (4.5 g every 8 h) was started for thoracic spondylitis (Fig. 2), and CT-guided drainage was performed at the T1/2 disk level. A few days later, blood, urine, and abscess cultures became positive for